On the fate of singularities and horizons in higher derivative gravity

We study static spherically symmetric solutions of high derivative gravity theories, with 4, 6, 8 and even 10 derivatives. Except for isolated points in the space of theories with more than 4 derivatives, only solutions that are nonsingular near the origin are found. But these solutions cannot smooth out the Schwarzschild singularity without the appearance of a second horizon. This conundrum, and the possibility of singularities at finite r, leads us to study numerical solutions of theories truncated at four derivatives. Rather than two horizons we are led to the suggestion that the original horizon is replaced by a rapid nonsingular transition from weak to strong gravity. We also consider this possibility for the de Sitter horizon.Comment: 15 pages, 3 figures, improvements and references added, to appear in PR

Energy in Generic Higher Curvature Gravity Theories

We define and compute the energy of higher curvature gravity theories in arbitrary dimensions. Generically, these theories admit constant curvature vacua (even in the absence of an explicit cosmological constant), and asymptotically constant curvature solutions with non-trivial energy properties. For concreteness, we study quadratic curvature models in detail. Among them, the one whose action is the square of the traceless Ricci tensor always has zero energy, unlike conformal (Weyl) gravity. We also study the string-inspired Einstein-Gauss-Bonnet model and show that both its flat and Anti-de-Sitter vacua are stable.Comment: 18 pages, typos corrected, one footnote added, to appear in Phys. Rev.

Extended Gravity Theories and the Einstein-Hilbert Action

I discuss the relation between arbitrarily high-order theories of gravity and scalar-tensor gravity at the level of the field equations and the action. I show that $(2n+4)$-order gravity is dynamically equivalent to Brans-Dicke gravity with an interaction potential for the Brans-Dicke field and $n$ further scalar fields. This scalar-tensor action is then conformally equivalent to the Einstein-Hilbert action with $n+1$ scalar fields. This clarifies the nature and extent of the conformal equivalence between extended gravity theories and general relativity with many scalar fields.Comment: 12 pages, Plain Latex, SUSSEX-AST-93/7-

Hospitality entrepreneurs managing quality of life and business growth

The hospitality industry is dominated by small- and medium-sized enterprises (SMEs).They are often led by entrepreneurs who face the challenge of simultaneously managing business decisions and their own wellbeing. The competitiveness of tourism destinations often depends on these entrepreneurs and therefore understanding their motivations and work patterns is critical. Research on individual wellbeing increasingly builds on the concept of quality of life (QoL). Hospitality and tourism literature so far predominantly focused on investigating QoL for tourists and residents, rather than for entrepreneurs’ QoL, even though being key stakeholders in the hospitality industry. Therefore, this study explores the factors influencing hospitality entrepreneurs’ quality of life (“HE-QoL”) and how these relate to business growth. Results of a 380 hospitality entrepreneurs’ survey identify six distinct factors of HE-QoL. Two groups of HE-QoL are identified with significant differences in fitness level activity, entrepreneurial competencies and business growth. Findings lead to recommendations to reduce stress to improve HE-QoL, and to develop entrepreneurial competencies, which help to cope with entrepreneurial challenges. Tourism destinations and politics can support hospitality entrepreneurs in these actions by creating conditions that foster social exchange in regional communities and trust in political and economic stability

Cooperative core competencies in tourism: Combining resource-based and relational approaches in destination governance

Community-based tourist destinations can be understood as networks of tourism service providers, which need to combine their resources and competencies to generate the overall holiday experience. Building on strategic management theories, the study aims at exploring the relationship between the destinations management’s reflexive capabilities and the cooperative core competencies of a tourist destination. By means of reflexive capabilities, destination management is suggested to be able to induce a high level of network quality, which in turn may be a pre-condition for the interlacing of the service providers’ competencies and resources, i.e. for the development of cooperative core competencies. Based on a quantitative survey in Bavaria, the results support these assumptions and indicate that reflexive capabilities may promote the development of cooperative core competencies in tourist destinations. The paper advances tourism literature by introducing, operationalizing and testing the idea of cooperative core competencies in the context of tourist destinations

PCSK9 Activity Is Potentiated Through HDL Binding

RationaleProprotein convertase subtilisin/kexin type 9 (PCSK9) circulates in a free and lipoprotein-bound form, yet the functional consequence of the association between PCSK9 and high-density lipoprotein (HDL) remains unexplored.ObjectiveThis study sought to interrogate the novel relationship between PCSK9 and HDL in humans.Methods and resultsComparing lipoprotein and apolipoprotein profiles by nuclear magnetic resonance and targeted mass spectrometry measurements with PCSK9 levels in the community-based Bruneck (n=656) study revealed a positive association of plasma PCSK9 with small HDL, alongside a highly significant positive correlation between plasma levels of PCSK9 and apolipoprotein-C3, an inhibitor of lipoprotein lipase. The latter association was replicated in an independent cohort, the SAPHIR study (n=270). Thus, PCSK9-HDL association was determined during the postprandial response in two dietary studies (n=20 participants each, 8 times points). Peak triglyceride levels coincided with an attenuation of the PCSK9-HDL association, a loss of apolipoprotein-C3 from HDL and lower levels of small HDL as measured by nuclear magnetic resonance. Crosslinking mass spectrometry (XLMS) upon isolated HDL identified PCSK9 as a potential HDL-binding partner. PCSK9 association with HDL was confirmed through size-exclusion chromatography and immuno-isolation. Quantitative proteomics upon HDL isolated from patients with coronary artery disease (n=172) returned PCSK9 as a core member of the HDL proteome. Combined interrogation of the HDL proteome and lipidome revealed a distinct cluster of PCSK9, phospholipid transfer protein, clusterin and apolipoprotein-E within the HDL proteome, that was altered by sex and positively correlated with sphingomyelin content. Mechanistically, HDL facilitated PCSK9-mediated low-density lipoprotein receptor degradation and reduced low-density lipoprotein uptake through the modulation of PCSK9 internalisation and multimerisation.ConclusionsThis study reports HDL as a binder of PCSK9 and regulator of its function. The combination of -omic technologies revealed postprandial lipaemia as a driver of PCSK9 and apolipoprotein-C3 release from HDL

The regeneration capacity of the flatworm Macrostomum lignano—on repeated regeneration, rejuvenation, and the minimal size needed for regeneration

The lion’s share of studies on regeneration in Plathelminthes (flatworms) has been so far carried out on a derived taxon of rhabditophorans, the freshwater planarians (Tricladida), and has shown this group’s outstanding regeneration capabilities in detail. Sharing a likely totipotent stem cell system, many other flatworm taxa are capable of regeneration as well. In this paper, we present the regeneration capacity of Macrostomum lignano, a representative of the Macrostomorpha, the basal-most taxon of rhabditophoran flatworms and one of the most basal extant bilaterian protostomes. Amputated or incised transversally, obliquely, and longitudinally at various cutting levels, M. lignano is able to regenerate the anterior-most body part (the rostrum) and any part posterior of the pharynx, but cannot regenerate a head. Repeated regeneration was observed for 29 successive amputations over a period of almost 12 months. Besides adults, also first-day hatchlings and older juveniles were shown to regenerate after transversal cutting. The minimum number of cells required for regeneration in adults (with a total of 25,000 cells) is 4,000, including 160 neoblasts. In hatchlings only 1,500 cells, including 50 neoblasts, are needed for regeneration. The life span of untreated M. lignano was determined to be about 10 months

Absolute Quantification of Plasma Apolipoproteins for Cardiovascular Disease Risk Prediction

Apolipoproteins have important structural and functional roles in several lipoprotein particles. Apolipoproteins regulate lipid metabolism, adipose tissue, and energy production and serve major regulatory roles in both pre- and pro-atherosclerotic mechanisms. They are also involved in protective mechanisms against atherosclerotic plaques. Therefore, accurate quantification of apolipoproteins may serve as a crucial biomarker for cardiovascular diseases. However, most apolipoproteins cannot be detected using standard clinical immunoassays, and multiplexing is not available for some species of apolipoproteins. Herein, we describe a highly robust and quantitative method using liquid chromatography coupled to tandem mass spectrometry to quantify apolipoproteins in plasma. This methodology may add clinical value for profiling cardiovascular risk in vulnerable individuals and enable monitoring of apolipoprotein levels in plasma following intervention strategies.Australian Research Council Discovery Early Career Research Award at the University of New South Wales, Sydney, AustraliaN.B. is the recipient of the Australian Research Council Discovery Early Career Research Award at the University of New SouthWales, Sydney, Australia

‘Kamikaze’ heritage tourism in Japan: A pathway to peace and understanding?

Reflecting the wider belief that international tourism offers the opportunity to encourage peace and understanding amongst peoples and nations, one objective of Japan’s recent tourism development policy is the enhancement of mutual understanding and the promotion of international peace. The purpose of this paper is to consider the extent to which this objective is achievable, particularly in the context of continuing controversy surrounding the country’s confrontation of its twentieth century military heritage in general and its role in the Pacific War in particular. Based on research at two ‘difficult’ heritage sites, Chiran Peace Museum in Kagoshima Prefecture and Yūshūkan War Museum in Tokyo, it explores specifically how the kamikaze phenomenon is commemorated and interpreted for international visitors, in so doing revealing a significant degree of dissonance at both sites. Not only is a selective narrative of heroic sacrifice presented within a wider revisionist history of the Pacific War but also no attempt is made to acknowledge the prevailing cultural context that might underpin a more nuanced understanding of the kamikaze. Hence, the paper concludes that a meaningful opportunity to enhance international understanding has been missed