Covariant Magnetic Connection Hypersurfaces

In the single fluid, nonrelativistic, ideal-Magnetohydrodynamic (MHD) plasma description magnetic field lines play a fundamental role by defining dynamically preserved "magnetic connections" between plasma elements. Here we show how the concept of magnetic connection needs to be generalized in the case of a relativistic MHD description where we require covariance under arbitrary Lorentz transformations. This is performed by defining 2-D {\it magnetic connection hypersurfaces} in the 4-D Minkowski space. This generalization accounts for the loss of simultaneity between spatially separated events in different frames and is expected to provide a powerful insight into the 4-D geometry of electromagnetic fields when ${\bf E} \cdot {\bf B} = 0$.Comment: 10 pages no figure

Genetic diagnosis as a tool for personalized treatment of Duchenne muscular dystrophy

Accurate definition of genetic mutations causing Duchenne muscular dystrophy (DMD) has always been relevant in order to provide genetic counseling to patients and families, and helps to establish the prognosis in the case where the distinction between Duchenne, Becker, or intermediate muscular dystrophy is not obvious. As molecular treatments aimed at dystrophin restoration in DMD are increasingly available as commercialized drugs or within clinical trials, genetic diagnosis has become an indispensable tool in order to determine eligibility for these treatments. DMD patients in which multiplex ligation-dependent probe amplification (MLPA) or similar techniques show a deletion suitable to exon skipping of exons 44, 45, 51, or 53, may be currently treated with AONs targeting these exons, in the context of clinical trials, or, as is the case for exon 51 skipping in the United States, with the first commercialized drug (eteplirsen). Patients who test negative at MLPA, but in whom DMD gene sequencing shows a nonsense mutation, may be amenable for treatment with stop codon readthrough compounds such as ataluren. Novel molecular approaches such as CRISPR-Cas9 targeting of specific DMD mutations are still in the preclinical stages, but appear promising. In conclusion, an accurate genetic diagnosis represents the entrance into a new scenario of personalized medicine in DMD

Generalised relativistic Ohm's laws, extended gauge transformations and magnetic linking

Generalisations of the relativistic ideal Ohm's law are presented that include specific dynamical features of the current carrying particles in a plasma. Cases of interest for space and laboratory plasmas are identified where these generalisations allow for the definition of generalised electromagnetic fields that transform under a Lorentz boost in the same way as the real electromagnetic fields and that obey the same set of homogeneous Maxwell's equations

An Action Principle for Relativistic MHD

A covariant action principle for ideal relativistic magnetohydrodynamics (MHD) in terms of natural Eulerian field variables is given. This is done by generalizing the covariant Poisson bracket theory of Marsden et al., which uses a noncanonical bracket to effect constrained variations of an action functional. Various implications and extensions of this action principle are also discussed. Two significant by-products of this formalism are the introduction of a new divergence-free 4-vector variable for the magnetic field, and a new Lie-dragged form for the theory

Switching VARMA Term Structure Models - Extended Version.

The purpose of the paper is to propose a global discrete-time modeling of the term structure of interest rates able to capture simultaneously the following important features : (i) an historical dynamics of the factor driving term structure shapes involving several lagged values, and switching regimes; (ii) a specification of the stochastic discount factor (SDF) with time-varying and regime dependent risk-premia; (iii) explicit or quasi explicit formulas for zero-coupon bond and interest rate derivative prices; (iv) the positivity of the yields at each maturity. The first family of models we develop is given by the Switching Autoregressive Normal (SARN) and the Switching Vector Autoregressive Normal (SVARN) Factor-Based Term Structure Models of order p. The second family of models we study is given by the Switching Autoregressive Gamma (SARG) and the Switching Vector Autoregressive Gamma (SVARG) Factor-Based Term Structure Models of order p. Regime shifts are described by a Markov chain with (historical) non-homogeneous transition probabilities.Affine Term Structure Models ; Stochastic Discount Factor ; Car processes ; Switching Regimes ; VARMA processes ; Lags ; Positivity ; Derivative Pricing.

"Magneto-elastic" waves in an anisotropic magnetised plasma

The linear waves that propagate in a two fluid magnetised plasma allowing for a non-gyrotropic perturbed ion pressure tensor are investigated. For perpendicular propagation and perturbed fluid velocity a low frequency (magnetosonic) and a high frequency (ion Bernstein) branch are identified and discussed. For both branches a comparison is made with the results of a truncated Vlasov treatment. For the low frequency branch we show that a consistent expansion procedure allows us to recover the correct expression of the Finite Larmor Radius corrections to the magnetosonic dispersion relation.Comment: 16 pages, 9 figure

Pricing and Inference with Mixtures of Conditionally Normal Processes.

We consider the problems of derivative pricing and inference when the stochastic discount factor has an exponential-affine form and the geometric return of the underlying asset has a dynamics characterized by a mixture of conditionally Normal processes. We consider both the static case in which the underlying process is a white noise distributed as a mixture of Gaussian distributions (including extreme risks and jump diffusions) and the dynamic case in which the underlying process is conditionally distributed as a mixture of Gaussian laws. Semi-parametric, non parametric and Switching Regime situations are also considered. In all cases, the risk-neutral processes and explicit pricing formulas are obtained.Derivative Pricing ; Stochastic Discount Factor ; Implied Volatility, Mixture of Normal Distributions ; Mixture of Conditionally Normal Processes ; Nonparametric Kernel Estimation ; Mixed-Normal GARCH Processes ; Switching Regime Models.

Expansion of a finite size plasma in vacuum

The expansion dynamics of a finite size plasma is examined from an analytical perspective. Results regarding the charge distribution as well as the electrostatic potential are presented. The acceleration of the ions and the associated cooling of the electrons that takes place during the plasma expansion is described. An extensive analysis of the transition between the semi infinite and the finite size plasma behaviour is carried out. Finally, a test of the analytical results, performed through numerical simulations, is presented.Comment: 4 pages with 5 figure