SSthreshless Start: A Sender-Side TCP Intelligence for Long Fat Network

Measurement shows that 85% of TCP flows in the internet are short-lived flows that stay most of their operation in the TCP startup phase. However, many previous studies indicate that the traditional TCP Slow Start algorithm does not perform well, especially in long fat networks. Two obvious problems are known to impact the Slow Start performance, which are the blind initial setting of the Slow Start threshold and the aggressive increase of the probing rate during the startup phase regardless of the buffer sizes along the path. Current efforts focusing on tuning the Slow Start threshold and/or probing rate during the startup phase have not been considered very effective, which has prompted an investigation with a different approach. In this paper, we present a novel TCP startup method, called threshold-less slow start or SSthreshless Start, which does not need the Slow Start threshold to operate. Instead, SSthreshless Start uses the backlog status at bottleneck buffer to adaptively adjust probing rate which allows better seizing of the available bandwidth. Comparing to the traditional and other major modified startup methods, our simulation results show that SSthreshless Start achieves significant performance improvement during the startup phase. Moreover, SSthreshless Start scales well with a wide range of buffer size, propagation delay and network bandwidth. Besides, it shows excellent friendliness when operating simultaneously with the currently popular TCP NewReno connections.Comment: 25 pages, 10 figures, 7 table

Reliable Diversity-Based Spatial Crowdsourcing by Moving Workers

With the rapid development of mobile devices and the crowdsourcig platforms, the spatial crowdsourcing has attracted much attention from the database community, specifically, spatial crowdsourcing refers to sending a location-based request to workers according to their positions. In this paper, we consider an important spatial crowdsourcing problem, namely reliable diversity-based spatial crowdsourcing (RDB-SC), in which spatial tasks (such as taking videos/photos of a landmark or firework shows, and checking whether or not parking spaces are available) are time-constrained, and workers are moving towards some directions. Our RDB-SC problem is to assign workers to spatial tasks such that the completion reliability and the spatial/temporal diversities of spatial tasks are maximized. We prove that the RDB-SC problem is NP-hard and intractable. Thus, we propose three effective approximation approaches, including greedy, sampling, and divide-and-conquer algorithms. In order to improve the efficiency, we also design an effective cost-model-based index, which can dynamically maintain moving workers and spatial tasks with low cost, and efficiently facilitate the retrieval of RDB-SC answers. Through extensive experiments, we demonstrate the efficiency and effectiveness of our proposed approaches over both real and synthetic data sets.Comment: 16 page

Visualizing topological edge states of single and double bilayer Bi supported on multibilayer Bi(111) films

Freestanding single-bilayer Bi(111) is a two-dimensional topological insulator with edge states propagating along its perimeter. Given the interlayer coupling experimentally, the topological nature of Bi(111) thin films and the impact of the supporting substrate on the topmost Bi bilayer are still under debate. Here, combined with scanning tunneling microscopy and first-principles calculations, we systematically study the electronic properties of Bi(111) thin films grown on a NbSe2 substrate. Two types of non-magnetic edge structures, i.e., a conventional zigzag edge and a 2x1 reconstructed edge, coexist alternately at the boundaries of single bilayer islands, the topological edge states of which exhibit remarkably different energy and spatial distributions. Prominent edge states are persistently visualized at the edges of both single and double bilayer Bi islands, regardless of the underlying thickness of Bi(111) thin films. We provide an explanation for the topological origin of the observed edge states that is verified with first-principles calculations. Our paper clarifies the long-standing controversy regarding the topology of Bi(111) thin films and reveals the tunability of topological edge states via edge modifications.Comment: 36 pages, 10 figure

Chloroplast SRP43 acts as a chaperone for glutamyl-tRNA reductase, the rate-limiting enzyme in tetrapyrrole biosynthesis

Assembly of light-harvesting complexes requires synchronization of chlorophyll (Chl) biosynthesis with biogenesis of light-harvesting Chl a/b-binding proteins (LHCPs). The chloroplast signal recognition particle (cpSRP) pathway is responsible for transport of nucleus-encoded LHCPs in the stroma of the plastid and their integration into the thylakoid membranes. Correct folding and assembly of LHCPs require the incorporation of Chls, whose biosynthesis must therefore be precisely coordinated with membrane insertion of LHCPs. How the spatiotemporal coordination between the cpSRP machinery and Chl biosynthesis is achieved is poorly understood. In this work, we demonstrate a direct interaction between cpSRP43, the chaperone that mediates LHCP targeting and insertion, and glutamyl-tRNA reductase (GluTR), a rate-limiting enzyme in tetrapyrrole biosynthesis. Concurrent deficiency for cpSRP43 and the GluTR-binding protein (GBP) additively reduces GluTR levels, indicating that cpSRP43 and GBP act nonredundantly to stabilize GluTR. The substrate-binding domain of cpSRP43 binds to the N-terminal region of GluTR, which harbors aggregation-prone motifs, and the chaperone activity of cpSRP43 efficiently prevents aggregation of these regions. Our work thus reveals a function of cpSRP43 in Chl biosynthesis and suggests a striking mechanism for posttranslational coordination of LHCP insertion with Chl biosynthesis

Radiometric dating of late Quaternary loess in the northern piedmont of South Tianshan Mountains: Implications for reliable dating

Reliable chronologies are prerequisites when interpreting proxy records in terrestrial archives of Quaternary climate and environmental change. Optically stimulated luminescence (OSL) dating and accelerator mass spectrometry radiocarbon dating (AMS C-14) are commonly used to date late Quaternary loess deposits in the Chinese Loess Plateau, but the range and reliability of the two methods in Central Asia are still debated. In this study, we investigate both fine-grained quartz OSL and AMS C-14 dating of a late Quaternary loess section located at the northern piedmont of the South Tianshan Mountains in Central Asia and discuss the reliability of the two radiometric dating methods. The results show that the OSL and AMS C-14 ages are generally consistent with the stratigraphic sequence when the ages are younger than 25cal ka BP, which means that both can be used to establish a reliable chronology in the Ili Basin. But beyond this age, the OSL dating method seems to be a more reliable approach. The results also supported previous dates based on medium-grained quartz OSL dating of the Ili loess in the southern piedmont of the North Tianshan Mountains. Radiocarbon ages older than 25cal ka BP should be treated with caution, and attention must be paid to the influence of pedoturbation on OSL signals in the Central Asian loess. Multiple dating approaches for mutual authentication and exploring new dating materials are suggested in further loess chronological research. These findings will be helpful in establishing a reliable timescale and in reconstructing high-resolution environmental change in Central Asia

Data from a comparative proteomic analysis of tumor-derived lung-cancer CD105+ endothelial cells

AbstractIncreasing evidence indicates that tumor-derived endothelial cells (TECs) are more relevant for the study of tumor angiogenesis and for screening antiangiogenic drugs than normal ECs (NECs). In this data article, high-purity (>98%) primary CD105+ NECs and TECs purified from a mouse Lewis lung carcinoma model bearing 0.5cm tumors were identified using 2D-PAGE and Matrix-assisted laser desorption/ionization tandem mass spectrometry (MALDI-MS/MS). All the identified proteins were categorized functionally by Gene Ontology (GO) analysis, and gene-pathway annotated by Kyoto Encyclopedia of Genes and Genomes (KEGG). Finally, protein–protein interaction networks were also built. The proteomics and bioinformatics data presented here provide novel insights into the molecular characteristics and the early modulation of the TEC proteome in the tumor microenvironment

Experimental Single-Photon Transmission from Satellite to Earth

Free-space quantum communication with satellites opens a promising avenue for global secure quantum network and large-scale test of quantum foundations. Recently, numerous experimental efforts have been carried out towards this ambitious goal. However, one essential step - transmitting single photons from the satellite to the ground with high signal-to-noise ratio (SNR) at realistic environments - remains experimental challenging. Here, we report a direct experimental demonstration of the satellite-ground transmission of a quasi-single-photon source. In the experiment, single photons (~0.85 photon per pulse) are generated by reflecting weak laser pulses back to earth with a cube-corner retro-reflector on the satellite Champ, collected by a 600-mm diameter telescope at the ground station, and finally detected by single-photon counting modules (SPCMs) after 400-km free-space link transmission. With the help of high accuracy time synchronization, narrow receiver field-of-view (FOV) and high-repetition-rate pulses (76 MHz), a SNR of better than 16:1 is obtained, which is sufficient for a secure quantum key distribution. Our experimental results represent an important step towards satellite-ground quantum communication