Hidden scars in depression? Implicit and explicit self-associations following recurrent depressive episodes

To help explain the recurrent nature of major depressive disorder, we tested the hypothesis that depressive episodes and/or the duration of depressive symptoms may give rise to persistent dysfunctional implicit and/or more explicit self-associations, which in turn may place people at risk for the recurrence of symptoms. We therefore examined, in the context of the Netherlands Study of Depression and Anxiety, whether the strength of self-depressed associations at baseline was related to the number of past episodes (retrospective analysis; n = 666), and whether the duration of symptoms between baseline and follow-up predicted self-depressed associations at 2-year follow-up (prospective analysis; n = 726). The lifetime Composite International Diagnostic Interviews and Life Chart Interview were used to index the number of depressive episodes; the Implicit Association Test and its explicit equivalent were used to index self-associations. Consistent with the hypothesis that self-depressed associations strengthen following prolonged activation of negative self-associations during depressive episodes, individuals' implicit and explicit self-depressed associations correlated positively both with the number of prior depressive episodes at baseline and with the duration of depressive symptoms between baseline and 2-year follow-up. There was evidence that these relationships held, particularly in the prospective study, even when controlling for neuroticism and current depressive symptoms, whereas the retrospective relationship between number of episodes and implicit self-associations fell just short of significance

Reduced hypothalamic-pituitary-adrenal axis activity in chronic multi-site musculoskeletal pain : partly masked by depressive and anxiety disorders

Peer reviewedPublisher PD

Recovery of the X-Ray Transient QX Nor (=X1608-52) in Outburst and Quiescence

We present optical and near-IR observations of QX Nor, the counterpart to the recurrent soft X-ray transient X1608-52, after its reappearance following the X-ray outburst in February 1996. The object has been seen only once before, during an X-ray outburst in 1977. Data from 3-5 months after the outburst show the counterpart at a mean magnitude of R=20.2 and variable on timescales of days. A comparison with identical observations in 1995 implies that the object has brightened by at least 1.8 mag in R following the X-ray outburst. We also detected QX Nor in the IR in both quiescence and outburst. A faint source is visible in the J but not the R band in May 1995. These first observations in the quiescent state yield magnitudes and colors consistent with optical emission from a low mass companion in the binary system, as is true in other soft X-ray transients.Comment: 10 pages including 4 figures and 2 tables; Uses AASTeX 4.0; Accepted for publication in The Astrophysical Journal, Volume 485, August 20, 199

Evaluating Spectral Models and the X-ray States of Neutron-Star X-ray Transients

We propose a hybrid model to fit the X-ray spectra of atoll-type X-ray transients in the soft and hard states. This model uniquely produces luminosity tracks that are proportional to T^4 for both the accretion disk and boundary layer. The model also indicates low Comptonization levels for the soft state, gaining a similarity to black holes in the relationship between Comptonization level and the strength of integrated rms variability in the power density spectrum. The boundary layer appears small, with a surface area that is roughly constant across soft and hard states. This result may suggestion that the NS radius is smaller than its inner-most stable circular orbit.Comment: 15 pages, 15 figures, accepted for publication in the Ap

The association of childhood maltreatment with depression and anxiety is not moderated by the oxytocin receptor gene

Background: The oxytocin receptor (OXTR) gene may be involved in resilience or vulnerability towards stress, and hence in the development of stress-related disorders. There are indications that OXTR single nucleotide polymorphisms (SNPs) interact with early life stressors in predicting levels of depression and anxiety. To replicate and extend these findings, we examined whether three literature-based OXTR SNPs (rs2254298, rs53576, rs2268498) interact with childhood maltreatment in the development of clinically diagnosed depression and anxiety disorders. Methods: We included 2567 individuals from the Netherlands Study of Depression and Anxiety. This sample consisted of 387 healthy controls, 428 people with a current or past depressive disorder, 243 people with a current or past anxiety disorder, and 1509 people with both lifetime depression and anxiety diagnoses. Childhood maltreatment was measured with both an interview and via self-report. Additional questionnaires measured depression and anxiety sensitivity. Results: Childhood maltreatment was strongly associated with both lifetime depression and anxiety diagnoses, as well as with depression and anxiety sensitivity. However, the OXTR SNPs did not moderate these associations nor had main effects on outcomes. Conclusions: The three OXTR gene SNPs did not interact with childhood maltreatment in predicting lifetime depression and anxiety diagnoses or sensitivity. This stresses the importance of replication studies with regard to OXTR gene variants in general populations as well as in clearly established clinical samples

Is alcohol consumption irrelevant to outcome in anxiety and depression? Reply

Stress-related psychiatric disorders across the life spa

Disappearance of Hard X-ray Emission in the Last BeppoSAX Observation of the Z Source GX 349+2

We report on the results from two BeppoSAX observations of the Z source GX 349+2 performed in February 2001 and covering the broad energy range 0.12-200 keV. The light curve obtained from these observations shows a large flaring activity, the count rate varying from ~130 to ~260 counts/s, indicating that the source was in the flaring branch during these observations. The average spectrum is well described by a soft blackbody and a Comptonized component. To well fit the energy spectrum three gaussian lines are needed at 1.2 keV, 2.6 keV, and 6.7 keV with corresponding equivalent widths of 13 eV, 10 eV, and 39 eV, probably associated to L-shell emission of Fe XXIV, Ly-alpha S XVI, and Fe XXV, respectively. These lines may be produced at different distances from the neutron star, which increase when the count rate of the source increases. An absorption edge is also needed at 9 keV with an optical depth of ~3 10^{-2}. From the Color-Color Diagram (CD) we selected five zones from which we extracted the corresponding energy spectra. The temperatures of the blackbody and of the Comptonized component tend to increase when the intensity of the source increases. We discuss our results comparing them to those obtained from a previous BeppoSAX observation, performed in March 2000, during which the source was a similar position of its Z-track. In particular we find that, although the source showed similar spectral states in the 2000 and the 2001 observations, a hard tail, that was significantly detected in March 2000, is not observed in these recent observations.Comment: Accepted for publication on Ap

Integration against the state: irregular migrants’ agency between deportation and regularisation in the United Kingdom

Reducing the number of foreigners residing unlawfully within the borders of a state requires either their removal or the legalisation of their presence within the territory. Increasingly, governments also employ measures of internal control and limit irregular migrants’ access to rights and services in order to encourage them to leave autonomously. This article aims to contribute to current debates on how to conceptualise and account for the agency that irregular migrants themselves exercise in such contexts. Within critical migration and citizenship studies, many of their everyday actions have been described as ‘acts of citizenship’ but also as instances of ‘becoming imperceptible’, neither of which captures the whole range of strategies irregular migrants employ to strengthen their fragile position vis-à-vis the state. I argue that conceptualising their agency in terms of (self-)integration allows us to account for both: practices through which they actively become political subjects as well as those that precisely constitute a deliberate refusal to do so. Empirically, this is underpinned by an analysis of recent policy developments in the United Kingdom and a series of semi-structured interviews I conducted during 8 months of fieldwork in London with migrants experiencing different kinds and degrees of irregularity

Longitudinal associations of multiple physical symptoms with recurrence of depressive and anxiety disorders

Objective To examine longitudinal associations of multiple physical symptoms with recurrence of depressive and anxiety disorders. Methods Follow-up data of 584 participants with remitted depressive or anxiety disorders were used from the Netherlands Study of Depressive and Anxiety disorders. Multiple physical symptoms were measured at baseline (T1) and two-year follow-up (T2) by the Four-Dimensional Symptom Questionnaire (4DSQ) somatization subscale. Recurrence of depressive and anxiety disorders was assessed at two-year (T2) and four-year (T4) follow-up with the Composite International Diagnostic Interview. Logistic Generalized Estimating Equations were used to examine associations of multiple physical symptoms with recurrence of depressive and anxiety disorders. Depressive (IDS-SR) and anxiety symptoms (BAI), and other relevant covariates were taken into account. Results Multiple physical symptoms were significantly associated with recurrence of depression (OR = 1.04, 95%CI = 1.00–1.08), anxiety (OR = 1.07, 95%CI = 1.03–1.12), and depressive or anxiety disorders (OR = 1.06, 95%CI = 1.02–1.10), on average over time. Odds ratios did not change substantially when the IDS-SR mood-cognition and BAI subjective scale were included as covariates. Conclusion The presence of multiple physical symptoms was positively related to recurrence of depressive and anxiety disorders, independent of depressive and anxiety symptoms. Knowledge of risk factors for recurrence of depressive and anxiety disorders, such as the presence of multiple physical symptoms, could provide possibilities for better targeting interventions to prevent recurrence

Alcohol use disorders and the course of depressive and anxiety disorders

BACKGROUND: Inconsistent findings have been reported on the role of comorbid alcohol use disorders as risk factors for a persistent course of depressive and anxiety disorders. AIMS: To determine whether the course of depressive and/or anxiety disorders is conditional on the type (abuse or dependence) or severity of comorbid alcohol use disorders. METHOD: In a large sample of participants with current depression and/or anxiety (n = 1369) we examined whether the presence and severity of DSM-IV alcohol abuse or alcohol dependence predicted the 2-year course of depressive and/or anxiety disorders. RESULTS: The persistence of depressive and/or anxiety disorders at the 2-year follow-up was significantly higher in those with remitted or current alcohol dependence (persistence 62% and 67% respectively), but not in those with remitted or current alcohol abuse (persistence 51% and 46% respectively), compared with no lifetime alcohol use disorder (persistence 53%). Severe (meeting six or seven diagnostic criteria) but not moderate (meeting three to five criteria) current dependence was a significant predictor as 95% of those in the former group still had a depressive and/or anxiety disorder at follow-up. This association remained significant after adjustment for severity of depression and anxiety, psychosocial factors and treatment factors. CONCLUSIONS: Alcohol dependence, especially severe current dependence, is a risk factor for an unfavourable course of depressive and/or anxiety disorders, whereas alcohol abuse is not