523 research outputs found
Islam and Women's Literature in Europe : Reading Leila Aboulela and Ingy Mubiayi
L\u2019articolo analizza il rapporto tra Islam e condizione delle donne attraverso gli scritti letterari di Leila Aboulela e Ingy Mubiayi
Islam, gender and transnational belongings: narratives of young Muslim women of Egyptian origin in Italy
The article analyzes the multiple belongings of Italian Muslim young women of Egyptian origin
Dynamic Image-Based Modelling of Kidney Branching Morphogenesis
Kidney branching morphogenesis has been studied extensively, but the
mechanism that defines the branch points is still elusive. Here we obtained a
2D movie of kidney branching morphogenesis in culture to test different models
of branching morphogenesis with physiological growth dynamics. We carried out
image segmentation and calculated the displacement fields between the frames.
The models were subsequently solved on the 2D domain, that was extracted from
the movie. We find that Turing patterns are sensitive to the initial conditions
when solved on the epithelial shapes. A previously proposed diffusion-dependent
geometry effect allowed us to reproduce the growth fields reasonably well, both
for an inhibitor of branching that was produced in the epithelium, and for an
inducer of branching that was produced in the mesenchyme. The latter could be
represented by Glial-derived neurotrophic factor (GDNF), which is expressed in
the mesenchyme and induces outgrowth of ureteric branches. Considering that the
Turing model represents the interaction between the GDNF and its receptor RET
very well and that the model reproduces the relevant expression patterns in
developing wildtype and mutant kidneys, it is well possible that a combination
of the Turing mechanism and the geometry effect control branching
morphogenesis
Branch Mode Selection during Early Lung Development
Many organs of higher organisms, such as the vascular system, lung, kidney,
pancreas, liver and glands, are heavily branched structures. The branching
process during lung development has been studied in great detail and is
remarkably stereotyped. The branched tree is generated by the sequential,
non-random use of three geometrically simple modes of branching (domain
branching, planar and orthogonal bifurcation). While many regulatory components
and local interactions have been defined an integrated understanding of the
regulatory network that controls the branching process is lacking. We have
developed a deterministic, spatio-temporal differential-equation based model of
the core signaling network that governs lung branching morphogenesis. The model
focuses on the two key signaling factors that have been identified in
experiments, fibroblast growth factor (FGF10) and sonic hedgehog (SHH) as well
as the SHH receptor patched (Ptc). We show that the reported biochemical
interactions give rise to a Schnakenberg-type Turing patterning mechanisms that
allows us to reproduce experimental observations in wildtype and mutant mice.
The kinetic parameters as well as the domain shape are based on experimental
data where available. The developed model is robust to small absolute and large
relative changes in the parameter values. At the same time there is a strong
regulatory potential in that the switching between branching modes can be
achieved by targeted changes in the parameter values. We note that the sequence
of different branching events may also be the result of different growth
speeds: fast growth triggers lateral branching while slow growth favours
bifurcations in our model. We conclude that the FGF10-SHH-Ptc1 module is
sufficient to generate pattern that correspond to the observed branching modesComment: Initially published at PLoS Comput Bio
Genere e generazioni in transizione: il movimento delle donne in Marocco dall’indipendenza al post-rivolte arabe
Il saggio ripercorre la storia del movimento delle donne in Marocc
STUDENT-CENTERED LEARNING AND TEACHING PROCESS: TWO LECLESSES PLANS WITH PROCEDURES AND IMPLEMENTATION MODES
Drawing from the Routledge International Handbook of Student-centered Learning and Teaching (2021) and Bari’s Convention on Academic Didactic Innovation (2018), while bearing in mind the most relevant theories of modern pedagogy along with the consequent practical implementations of glottodidactics, this article focuses on the objectives of the EU program ET 2020.Great relevance is granted to the learning-teaching approach and the new roles of students and teachers, exemplified through a “lecless” sample plan with objectives, times, number and role of students involved, procedures and assessment. Some works presented by university students during their English classes are finally included
I movimenti delle donne nella regione MENA nel XXI secolo: percorsi, generazioni, definizioni
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