Hyperthermia Suppresses Post - In Vitro Proliferation and Tumor Growth in Murine Malignant Melanoma and Colon Carcinoma

Background: Several studies have highlighted hyperthermia’s ability to enhance the effectiveness of radiation and chemotherapy in various in vitro and in vivo cancer models. Materials and Methods: In vivo murine models of malignant melanoma and colon carcinoma were utilized for demonstrating hyperthermia’s therapeutic effectiveness by examining levels of caspase 3, COX-2 and phospho-H2A.X (Ser139) as endpoints of apoptosis, proliferation and DNA damage respectively. Results: Hyperthermia induced in vitro cytotoxicity in malignant melanoma (B16-F10) and colon carcinoma (CT26) cell lines. In addition, it reduced post-in vitro proliferation and suppression of tumor growth by inducing the expression of caspase-3 and phospho-H2A.X (Ser139) while reducing the expression of COX-2 in both murine cancer models. Conclusion: Hyperthermia can exert therapeutic effectiveness against melanoma and colon carcinoma by inhibiting a number of critical cellular cascades including apoptosis, proliferation and DNA damage

A contribuição do Programa De Iniciação Científica Júnior – Bic Júnior – no ingresso na Universidade Federal De Lavras.

O objetivo central do presente trabalho é identificar as contribuições do Programa BIC Jr. para o ingresso no ensino superior dos bolsistas que formaram tanto no 3º ano do ensino médio quanto no programa BIC Jr. no ano de 2014. Analisou-se ainda a contribuição para o desenvolvimento pessoal do bolsista, durante seu ingresso no Programa, a contribuição para a formação escolar e as contribuições do Programa BIC Jr. para a escolha do curso de graduação. A metodologia utilizada é caracterizada por um estudo de caso, que se orientou por uma abordagem qualitativa e descritiva. Quanto aos procedimentos técnicos, foi adotada uma abordagem documental, complementada por um questionário enviado a 18 ex-integrantes do Programa por email. Os resultados foram positivos, pois constatou que o Programa BIC Jr. contribuiu para o ingresso dos bolsistas que se formaram tanto no ensino médio quando no BIC Jr. em 2014

Uma breve exposição sobre filosofia da linguagem em Epicuro

Many critiques were made on the writing choices and writing style of the Epicureans, just as various attacks were voiced by different authors regarding the most varied topics in the works of the followers of this line of thought, with Epicurus always at the center of these attacks. However, regarding the language of the Epicureans, the sayings of his detractors were always very weak in arguments, either criticizing the lack of refinement, their simple writing style or the fact that they express themselves through common language. This work is an effort to connect different aspects of the philosopher's work on language in order to have a broad view into his perspective on the topic. Here an interpretive effort is made in an attempt to connect his ideas and notions to achieve our main task of bringing to light the foundations of the author's thought about language. Different pieces of text are here analyzed, focusing on the writings of Epicurus himself. The author's writings on which we focus this study are his Letter to Herodotus and book twenty eight of his work On Nature.Trabalho de Conclusão de Curso (Graduação)Diversas críticas foram tecidas sobre o tipo de escrita e o estilo da escrita dos epicuristas, assim como diversas críticas foram vociferadas por diversos autores aos mais variados aspectos das obras dos seguidores dessa linha filosófica, com Epicuro sempre no centro desses ataques. Contudo, sobre a linguagem dos epicuristas, o discurso dos detratores é bem superficial, criticando a falta de rebuscamento, uma simpleza de estilo e o fato de se expressarem por uma linguagem comum. Este trabalho é um esforço para conectar distintos aspectos da filosofia da linguagem do filósofo com o intuito de destacarmos sua visão sobre o tema de maneira abrangente. Aqui é feito um esforço interpretativo em uma tentativa de correlacionar ideias e noções do filósofo para nossa principal tarefa de expor os fundamentos do pensamento do autor acerca da linguagem. São analisados diferentes excertos com foco nos escritos do próprio Epicuro. Para este estudo são utilizados do autor os escritos Carta a Heródoto e o livro 28 da obra Sobre a Natureza

A New Side Effect of Intravitreal Dexamethasone Implant (Ozurdex®)

Dexamethasone implant, 0,7 mg (Ozurdex, Allergan, Inc., Irvine, CA, USA), is drug mostly used in the treatment of the diabetic macular edema and edema related to retinal vein occlusion. By reporting this case we aimed to report a new side effect of 0.7 mg intravitreal dexamethasone implant that has not been reported in the literature before

Retinal Artery Occlusion Secondary to Buerger’s Disease (Thromboangiitis Obliterans)

Purpose. To report a case report of one patient suffering from retinal artery occlusion secondary to Buerger’s disease, in order to raise awareness to this etiology in the differential diagnosis of retinal artery occlusion. Methods. A retrospective case report of a patient with retinal artery occlusion secondary to Buerger’s disease. Data retrieved from the medical records included exposure, complaints, visual acuity, clinical findings and imaging, laboratory assessment, treatment, disease course, and visual outcome. Results. Diagnosis of retinal artery occlusion secondary to Buerger’s disease was established based on ruling out other causes of retinal artery occlusion. Inflammatory retinal vascular disease, permanent vision loss, and macular atrophy were shown in this case. Conclusion. The very first case of central retinal artery occlusion (CRAO) in a 64-year-old male patient with Buerger’s disease. Although diagnosing CRAO based on both fundoscopic and fluorescein angiographic findings is not difficult, revealing underlying condition of CRAO occasionally could be challenging

Focal Laser Photocoagulation in Non-Center Involved Diabetic Macular Edema

This study was performed to evaluate the functional and anatomic outcomes of focal macular laser photocoagulation in eyes with non-center involved macular edema (non-CI ME). Forty-nine eyes of 43 patients with non-CI ME were included. Focal macular laser photocoagulation was conducted on twenty-nine eyes of 25 patients, while 20 eyes of 18 patients with non-CI ME were followed without treatment and served as the control group. Data relating to best corrected visual acuity (BCVA; Early Treatment Diabetic Retinopathy Study) and central subfield thickness (CST), inner zone thickness (IZT), outer zone thickness (OZT), and total macular volume (TMV) as determined by optical coherence tomography (OCT) were collected and compared between the groups. At 12 months, VA decreased by a mean of 0.4 letters in the treatment group and 3.3 letters in the control group (p=0.03). Gain in VA ≥5 letters was noted in 6 (21%) of the eyes in the treatment group versus 1 (5%) eye in the control group (p=0.12). At 12 months, average IZT decreased by 22.6 microns in the treatment group and increased by 10.9 microns in the control group (p<0.001). The treatment group revealed significant reduction in CST, average OZT, and TMV as compared to the control group at 12 months (all p<0.05).Generally, focal laser photocoagulation may have more favourable visual outcomes in this specific group of diabetic patients than does observation. In addition, focal laser treatment provided better outcomes with improvement in OCT parameters as compared to the control group

Real-World Outcomes of Anti-VEGF Treatment for Neovascular Age-Related Macular Degeneration in Turkey: A Multicenter Retrospective Study, Bosphorus Retina Study Group Report No: 1

Objectives: To evaluate the real-world outcomes of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment in neovascular age-related macular degeneration (nAMD) patients. Materials and Methods: Multicenter, retrospective, interventional, non-comparative study. The records of nAMD patients treated with an anti-VEGF agent on a pro re nata treatment regimen basis between January 2013 and December 2015 were reviewed. The patients who completed a follow-up period of 12 months were included. Primary outcome measures of this study were the visit and injection numbers during the first year. Results: Eight hundred eighty eyes of 783 patients met the inclusion criteria for the study. Mean number of visits at month 12 was 6.9±2.5 (range: 1-15). Mean number of injections at month 12 was 4.1±1.9 (range: 1-11). Mean visual acuity at baseline and months 3, 6, and 12 was 0.90±0.63 LogMAR (range: 0.0-3.0), 0.79±0.57 LogMAR (range: 0.0-3.0), 0.76±0.57 LogMAR (range: 0.0-3.0), and 0.79±0.59 LogMAR (range: 0.0-3.0), respectively. Mean central retinal thickness at baseline and months 6 and 12 was 395±153 μm (range: 91-1582), 330±115 μm (range: 99-975), and 332±114 μm (range: 106-1191), respectively. Conclusion: The numbers of visits and injections were much lower than ideal and were insufficient with the pro re nata treatment regimen