Impact of family structure on long-term survivors of osteosarcoma

Goals of work: Long-term outcomes of osteosarcoma have dramatically improved with the use of modern combination therapies. Such aggressive treatments, however, entail chronic complications. In the present study, we assessed the functional, psychological, and familial status of long-term survivors of osteosarcoma treated at our institution. Materials and methods: Fifteen long-term survivors of osteosarcoma were evaluated for functional and psychological sequelae. Functional assessment was based on a method described by Enneking et al. Psychological assessment was based on General Health Questionnaire 28, Inventory Scale for Traumatic Neurosis, and Family System Test. Main results: Ten patients showed mild functional impairments; only five patients were handicapped more seriously. Depressive symptoms were diagnosed in four patients. A total of six patients revealed unbalanced family structures, including three of the four patients with depressive symptoms, all four patients with symptoms of posttraumatic stress disorder, and five of seven patients who showed poor emotional acceptance. Conclusions: Osteosarcoma survivors will generally recover good functional performance. Only a minority of them remain seriously impaired. One third of the patients present depressive symptoms and posttraumatic stress disorder. Poor coping is closely associated with unbalanced family structures. Therefore, the psychological and familial situation of patients with newly diagnosed osteosarcoma should be carefully assesse

Prospective assessment of CYP2D6 by genotyping, phenotyping and measurement of tamoxifen, PD 05-09 4-hydroxy-tamoxifen and endoxifen in breast cancer patients treated with tamoxifen.

Tamoxifen (tam) is a widely used endocrine therapy in the treatment of early and advanced stage breast cancer in women and men. It is a pro-drug having weak affinity with the estrogen receptor and needs to be converted to its main metabolite, endoxifen (endox), to have full anticancer activity. Cytochrome 2D6 (CYP2D6) plays a major role in the metabolism of tamoxifen to endoxifen. It is genetically highly polymorphic and its activity influences profoundly the synthesis of endoxifen and potentially the efficacy of tamoxifen treatment. Genotyping is currently the most widely used approach in studies and also in clinical practice to categorize patients as poor- (PM), intermediate- (IM), extensive- (EM) and ultra rapid-metabolizers (UM). Some clinicians already use genotyping in order to tailor the endocrine therapy of their patients. Owing to the large inter-individual variations in concentrations of the active moitey due to genetic and non-genetic influences renders the predictive value of the test uncertain for an individual patient. A significant number of patients classified as EM or IM by genotyping have indeed relatively low endoxifen levels similar to PMs1. This suggests that genotyping is probably not the opti ma l meth o d f or predi cti ng end oxif en l evels

Many-body effects in 16O(e,e'p)

Effects of nucleon-nucleon correlations on exclusive $(e,e'p)$ reactions on closed-shell nuclei leading to single-hole states are studied using $^{16}O(e,e'p)^{15}N$ ($6.32$ MeV, $3/2^-$) as an example. The quasi-hole wave function, calculated from the overlap of translationally invariant many-body variational wave functions containing realistic spatial, spin and isospin correlations, seems to describe the initial state of the struck proton accurately inside the nucleus, however it is too large at the surface. The effect of short-range correlations on the final state is found to be largely cancelled by the increase in the transparency for the struck proton. It is estimated that the values of the spectroscopic factors obtained with the DWIA may increase by a few percent due to correlation effects in the final state.Comment: 21 Pages, PHY-7849-TH-9

Non-localities in nucleon-nucleus potentials

Two causes of non-locality inherent in nucleon-nucleus scattering are considered. They are the results of two-nucleon antisymmetry of the projectile with each nucleon in the nucleus and the dynamic polarization potential representation of channel coupling. For energies $\sim 40 - 300$ MeV, a g-folding model of the optical potential is used to show the influence of the knock-out process that is a result of the two-nucleon antisymmetry. To explore the dynamic polarization potential caused by channel coupling, a multichannel algebraic scattering model has been used for low-energy scattering.Comment: 12 pages, 11 figures, submitted to EPJ

A Microscopic T-Violating Optical Potential: Implications for Neutron-Transmission Experiments

We derive a T-violating P-conserving optical potential for neutron-nucleus scattering, starting from a uniquely determined two-body $\rho$-exchange interaction with the same symmetry. We then obtain limits on the T-violating $\rho$-nucleon coupling $\overline{g}_{\rho}$ from neutron-transmission experiments in $^{165}$Ho. The limits may soon compete with those from measurements of atomic electric-dipole moments.Comment: 8 pages, 2 uuencoded figures in separate files (replaces version sent earlier in the day with figures attached), in RevTeX 3, submitted to PR

Clinical benefit of fulvestrant in postmenopausal women with advanced breast cancer and primary or acquired resistance to aromatase inhibitors: final results of phase II Swiss Group for Clinical Cancer Research Trial (SAKK 21/00)

Background: The aim of this study was to evaluate the efficacy and tolerability of fulvestrant, an estrogen receptor antagonist, in postmenopausal women with hormone-responsive tumors progressing after aromatase inhibitor (AI) treatment. Patients and methods: This is a phase II, open, multicenter, noncomparative study. Two patient groups were prospectively considered: group A (n = 70) with AI-responsive disease and group B (n = 20) with AI-resistant disease. Fulvestrant 250 mg was administered as intramuscular injection every 28 (±3) days. Results: All patients were pretreated with AI and 84% also with tamoxifen or toremifene; 67% had bone metastases and 45% liver metastases. Fulvestrant administration was well tolerated and yielded a clinical benefit (CB; defined as objective response or stable disease [SD] for ≥24 weeks) in 28% (90% confidence interval [CI] 19% to 39%) of patients in group A and 37% (90% CI 19% to 58%) of patients in group B. Median time to progression (TTP) was 3.6 (95% CI 3.0 to 4.8) months in group A and 3.4 (95% CI 2.5 to 6.7) months in group B. Conclusions: Overall, 30% of patients who had progressed following prior AI treatment gained CB with fulvestrant, thereby delaying indication to start chemotherapy. Prior response to an AI did not appear to be predictive for benefit with fulvestran

From the Bethe-Salpeter equation to non-relativistic approaches with effective two-body interactions

It is known that binding energies calculated from the Bethe-Salpeter equation in ladder approximation can be reasonably well accounted for by an energy-dependent interaction, at least for the lowest states. It is also known that none of these approaches gives results close to what is obtained by using the same interaction in the so-called instantaneous approximation, which is often employed in non-relativistic calculations. However, a recently proposed effective interaction was shown to account for the main features of both the Bethe-Salpeter equation and the energy-dependent approach. In the present work, a detailed comparison of these different methods for calculating binding energies of a two-particle system is made. Some improvement, previously incorporated for the zero-mass boson case in the derivation of the effective interaction, is also employed for massive bosons. The constituent particles are taken to be distinguishable and spinless. Different masses of the exchanged boson (including a zero mass) as well as states with different angular momenta are considered and the contribution of the crossed two-boson exchange diagram is discussed. With this respect, the role played by the charge of the exchanged boson is emphasized. It is shown that the main difference between the Bethe-Salpeter results and the instantaneous approximation ones are not due to relativity as often conjectured.Comment: 38 pages, 12 eps figures, uses elsart.cls (included

A consistent analysis of (e,e'p) and (d,3He) experiments

The apparent discrepancy between spectroscopic factors obtained in (e,e'p) and (d,3He) experiments is investigated. This is performed first for 48Ca(e,e'p) and 48Ca(d,3He) experiments and then for other nuclei. It is shown that the discrepancy disappears if the (d,3He) experiments are re-analyzed with a non-local finite range DWBA analysis with a bound-state wave function that is obtained from (e,e'p) experiments.Comment: 23 pages, 7 figure

Nuclear Transparency to Intermediate-Energy Protons

Nuclear transparency in the (e,e'p) reaction for 135 < Tp < 800 MeV is investigated using the distorted wave approximation. Calculations using density-dependent effective interactions are compared with phenomenological optical potentials. Nuclear transparency is well correlated with proton absorption and neutron total cross sections. For Tp < 300 MeV there is considerable sensitivity to the choice of optical model, with the empirical effective interaction providing the best agreement with transparency data. For Tp > 300 MeV there is much less difference between optical models, but the calculations substantially underpredict transparency data and the discrepancy increases with A. The differences between Glauber and optical model calculations are related to their respective definitions of the semi-inclusive cross section. By using a more inclusive summation over final states the Glauber model emphasizes nucleon-nucleon inelasticity, whereas with a more restrictive summation the optical model emphasizes nucleon-nucleus inelasticity; experimental definitions of the semi-inclusive cross section lie between these extremes.Comment: uuencoded gz-compressed tar file containing revtex and bbl files and 5 postscript figures, totalling 31 pages. Uses psfi