The Effect of Nicotinic Acid on the Cerebral Circulation, with Observations on Extracerebral Contamination of Cerebral Venous Blood in the Nitrous Oxide Procedure for Cerebral Blood Flow

Measurement of cerebral blood flow by the nitrous oxide method before and during intravenous administration of nicotinic acid indicates that cerebral vessels do not respond to this drug. Evidence that contamination of cerebral by extracerebral blood occurs in about 20 per cent of subjects is adduced from the effects of nicotinic acid on the measured cerebral blood flows; studies making use of the intravascular catheter technic to sample internal jugular blood tend to confirm this hypothesis.</jats:p

An Introduction to Diagnosis and Management of Common Neurologic Disorder

xii;ill.;284hal.;20c

Cerebral Blood Flow and Metabolism in Pernicious Anemia

Abstract 1. Cerebral blood flow and metabolism were measured in 16 patients with pernicious anemia. Seven of the patients were restudied in various stages of therapy. 2. The patients fell into two equal groups, those with severe anemia and those with moderate or no anemia. In the first group, cerebral blood flow was increased and cerebral vascular resistance decreased; in the second group, cerebal blood flow was decreased and vascular resistance increased. In both groups, cerebral oxygen and glucose consumption was decreased, as was cerebral venous oxygen tension . 3. There was a good correlation between the mental status defects and cerebral oxygen consumption and between severity of neurologic involvement and cerebral oxygen consumption. There was no correlation between cerebro-vascular resistance and cerebral oxygen consumption, nor between degree of anemia and cerebral oxygen consumption. 4. Specific therapy resulted in a moderate increase in cerebral oxygen consumption and cerebro-vascular resistance. In no instance did cerebral oxygen consumption become normal. 5. The disparity between the functional ability of the patients and the low values for cerebral metabolism is discussed. 6. It is concluded that pernicious anemia results in specific nervous system involvement not related to the anemia, and that this damage is at least partially irreversible in many patients.</jats:p