2,707 research outputs found
Using of well logging methods within the frame of the experiment "Immobilization of contamination in-situ"
An experiment piloting the potential of the new in-situ remedy technique is described in this article. The article shows the well logging methods for the progress monitoring of the experiment on selected part of the uranium deposit in Straz pod Ralskem
Single phase current-source active rectifier for traction: control system design and practical problems
This research has been motivated by industrial demand for single phase current-source active rectifier dedicated
for reconstruction of older types of dc machine locomotives. This paper presents converters control structure design and
simulations. The proposed converter control is based on the mathematical model and due to possible interaction with railway
signaling and required low switching frequency employs synchronous PWM. The simulation results are verified by
experimental tests performed on designed laboratory prototype of power of 7kVA
Classical Electromagnetic Fields from Quantum Sources in Heavy-Ion Collisions
Electromagnetic fields are generated in high energy nuclear collisions by
spectator valence protons. These fields are traditionally computed by
integrating the Maxwell equations with point sources. One might expect that
such an approach is valid at distances much larger than the proton size and
thus such a classical approach should work well for almost the entire
interaction region in the case of heavy nuclei. We argue that, in fact, the
contrary is true: due to the quantum diffusion of the proton wave function, the
classical approximation breaks down at distances of the order of the system
size. We compute the electromagnetic field created by a charged particle
described initially as a Gaussian wave packet of width 1 fm and evolving in
vacuum according to the Klein-Gordon equation. We completely neglect the medium
effects. We show that the dynamics, magnitude and even sign of the
electromagnetic field created by classical and quantum sources are different.Comment: 12 pages, 4 figures. V2: a numerical error corrected, figures
improved, other minor improvement
G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.
Leaders In A Technologically Dispersed Work Environment
This study was designed to compare leaders and their employees to determine characteristics needed to successfully succeed in a virtual work environment and to compare and contrast expectations of characteristics needed in a traditional versus a virtual office environment. These characteristics were compared with Stephen Covey\u27s Principled Centered Leadership Model to determine if deviation in the virtual office will imply a need to change his leadership model.
Although there are differences in traditional office environments versus virtual work environment, Covey\u27s Principled Centered Leadership Model still essentially holds true. The leadership characteristics that will apply in a virtual office environment are service oriented, believing in other people, seeing life as an adventure and being synergistic. However, trust and independence ranked high as a new characteristic that Covey\u27s model did not cover and could produce an anomaly and a paradigm shift. A virtual leader must position their selves to be trustworthy and provide a structure that allows the team to accomplish goals, working together as a team, while working separately
Development of nanotherapeutics for the treatment of recalcitrant and antibiotic resistant infections
The main focus of this dissertation is on the use of polyanhydride nanoparticles as antimicrobial delivery vehicles to treat the diseases melioidosis caused by the bacterium Burkholderia pseudomallei and primary amoebic meningoencephalitis (PAM) caused by the free-living amoeba Naegleria fowleri.
Melioidosis represents a bacterial disease characterized by antimicrobial resistance, recrudesce, and high mortality. B. pseudomallei is classified as a category B bioterrorism agent as this agent has been studied as a potential bioweapon by various nations. This dissertation shows that these polyanhydride nanoparticles are effective at delivering the antibiotics meropenem, ceftazidime, and chloramphenicol against B. pseudomallei in in vitro broth assays and tissue culture cell models of intracellular pathogenesis.
PAM is a rare disease yet results in a fatal infection with close to 100% mortality with aggressive antimicrobial therapy. Antimicrobials recommended for the treatment of primary amoebic meningoencephalitis were loaded into nanoparticles and screened against N. fowleri in in vitro growth assays. When rifampicin and azithromycin were loaded into these nanoparticles, an improvement in anti-parasitic efficacy was noted.
In summary, these results bolster the effectiveness of polyanhydride nanoparticles as effective drug delivery vehicles across prokaryotic and eukaryotic pathogens.
Additional research discussed is the anti-parasitic activity of the anti-rheumatoid drug auranofin on N. fowleri. In vitro assays found that auranofin has an IC50 of 0.788 µg/mL with the HB-1 strain of N. fowleri. When these amoeba were treated with 3.0 µg/mL auranofin, staining of the nucleus with the cell membrane impermeable dye propidium iodide suggests that auranofin exerts amoebicidal activity. This data suggests that auranofin has potential as a therapy for primary amoebic meningoencephalitis.
Lastly, the impact that the catecholamine hormones norepinephrine and epinephrine have on the replication and antimicrobial susceptibility of Bacillus anthracis and Yersinia pestis. Bacillus anthracis is the causative agent behind the disease anthrax and Y. pestis is the cause of the many manifestation of plague. Norepinephrine was found to accelerate the replication of B. anthracis and render the bacteria less susceptible to the antibiotic rifampicin. While, norepinephrine and epinephrine had the inverse effect with Y. pestis and resulted in a decreased replication rate
Steady state torque optimal operating point control for wound rotor synchronous motors
This paper discusses steady state optimal control of the motor from the maximum torque point of view. The motor behavior is researched with a vector control supply in the full speed range. The optimal considerations are compared with a behavior of the classical control structures such as the unity power factor strategy
Active Elimination of Low-Frequency Harmonics of Traction Current-Source Active Rectifier
In this paper, a new control approach in activesuppression of low-frequency disturbances in the trolleywirecurrent using resonant (R) controllers is presented. Itis dedicated for a single-phase active current-sourcerectifier (ACSR) developed within the research into a newgeneration of main traction converters employing themedium-frequency transformer dedicated for suburbanunits operating on both ac electrification systems of 25kV/50 Hz and 15 kV/16,7 Hz. Proper function of proposedcontrol strategy with a new compensative principle has beenverified by simulations and large experimental study madeon designed small-scale prototype of ACSR of the ratedpower of 7 kVA
Diamond Detectors for the TOTEM Timing Upgrade
This paper describes the design and the performance of the timing detector
developed by the TOTEM Collaboration for the Roman Pots (RPs) to measure the
Time-Of-Flight (TOF) of the protons produced in central diffractive
interactions at the LHC. The measurement of the TOF of the protons allows the
determination of the longitudinal position of the proton interaction vertex and
its association with one of the vertices reconstructed by the CMS detectors.
The TOF detector is based on single crystal Chemical Vapor Deposition (scCVD)
diamond plates and is designed to measure the protons TOF with about 50 ps time
precision. This upgrade to the TOTEM apparatus will be used in the LHC run 2
and will tag the central diffractive events up to an interaction pileup of
about 1. A dedicated fast and low noise electronics for the signal
amplification has been developed. The digitization of the diamond signal is
performed by sampling the waveform. After introducing the physics studies that
will most profit from the addition of these new detectors, we discuss in detail
the optimization and the performance of the first TOF detector installed in the
LHC in November 2015.Comment: 26 pages, 18 figures, 2 tables, submitted for publication to JINS
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