Emerging role of the pentose phosphate pathway in hepatocellular carcinoma

In recent years, there has been a revival of interest in metabolic changes of cancer cells as it has been noticed that malignant transformation and metabolic reprogramming are closely intertwined. The pentose phosphate pathway (PPP) is one of the fundamental components of cellular metabolism crucial for cancer cells. This review will discuss recent findings regarding the involvement of PPP enzymes in several types of cancer, with a focus on hepatocellular carcinoma (HCC). We will pay considerable attention to the involvement of glucose-6-phosphate dehydrogenase, the rate-limiting enzyme of the PPP. Subsequently, we discuss the inhibition of the PPP as a potential therapeutic strategy against cancer, in particular, HCC

The spreading of infectious diseases in modern socio-technical systems. Comment on ''Pattern transitions in spatial epidemics: Mechanisms and emergent properties'' by Gui-Quan Sun et al

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The Scaling of Human Contacts in Reaction-Diffusion Processes on Heterogeneous Metapopulation Networks

We present new empirical evidence, based on millions of interactions on Twitter, confirming that human contacts scale with population sizes. We integrate such observations into a reaction-diffusion metapopulation framework providing an analytical expression for the global invasion threshold of a contagion process. Remarkably, the scaling of human contacts is found to facilitate the spreading dynamics. Our results show that the scaling properties of human interactions can significantly affect dynamical processes mediated by human contacts such as the spread of diseases, and ideas

Seminario sullo Standard MPEG-4: utilizzo ed aspetti implementativi

Una delle tecnologie chiave che hanno permesso il grande sviluppo della televisione digitale è la compressione video. La tecnologia di codifica video nota come MPEG-2, sviluppata nei primi anni novanta, è diventata lo standard di trasmissione DTV (Digital TV) sia satellitare sia terrestre in quasi tutti i paesi del mondo. Da allora la velocità dei microprocessori e le capacità di memoria dei dispositivi hardware per la codifica e la decodifica sono migliorate significativamente rendendo possibile lo sviluppo e l’implementazione di algoritmi di codifica innovativi in grado di abbattere significativamente i limiti di compressione dello standard MPEG-2. Tali innovazioni, sfociate nel 2003 nello standard MPEG-4 AVC (Advanced Video Coding), non hanno permesso di mantenere la compatibilità all’indietro con l’MPEG-2, e questo ha inizialmente costituito un limite alla loro introduzione nei sistemi di trasmissione DTV. Tuttavia, negli ultimi anni la codifica MPEG-4 AVC si è diffusa rapidamente, è stata adottata dal progetto DVB, recentemente dall’ATSC, ed è lo standard di codifica nell’IPTV. L’obiettivo di questo seminario, che si articola in due giornate, è quello di presentare lo standard di codifica MPEG-4 AVC con particolare attenzione agli aspetti implementativi del livello di codifica video.2008-11-18Sardegna Ricerche, Edificio 2, Località Piscinamanna 09010 Pula (CA) - ItaliaSeminario sullo Standard MPEG-4: utilizzo ed aspetti implementativ

The Belfast Youth Development Study (BYDS): A prospective cohort study of the initiation, persistence and desistance of substance use from adolescence to adulthood in Northern Ireland

Background: Substance misuse persists as a major public health issue worldwide with significant costs for society. The development of interventions requires methodologically sound studies to explore substance misuse causes and consequences. This Cohort description paper outlines the design of the Belfast Youth Development (BYDS), one of the largest cohort studies of its kind in the UK. The study was established to address the need for a long-term prospective cohort study to investigate the initiation, persistence and desistance of substance use, alongside life course processes in adolescence and adulthood. The paper provides an overview of BYDS as a longitudinal data source for investigating substance misuse and outlines the study measures, sample retention and characteristics. We also outline how the BYDS data have been used to date and highlight areas ripe for future work by interested researchers. Methods: The study began in 2000/1 when participants (n = 3,834) were pupils in their first year of post-primary education (age 10/11 years, school year 8) from over 40 schools in Northern Ireland. Children were followed during the school years: Year 9 (in 2002; aged 12; n = 4,343), Year 10 (in 2003; aged 13; n = 4,522), Year 11 (in 2004; aged 14; n = 3,965) and Year 12 (in 2005; aged 15; n = 3,830) and on two more occasions: 2006/07 (aged 16/17; n = 2,335) and 2010/11 (aged 20/21; n = 2,087). Data were collected on substance use, family, schools, neighbourhoods, offending behaviour and mental health. The most novel aspect of the study was the collection of detailed social network data via friendship nominations allowing the investigation of the spread of substance use via friendship networks. In 2004 (school year 11; respondents aged 14), a sub-sample of participants’ parents (n = 1,097) and siblings (n = 211) also completed measures on substance use and family dynamics. Results: The most recent wave (in 2010/2011; respondents aged 20/21 years) indicated lifetime use of alcohol, tobacco and cannabis among the cohort was 94, 70 and 45 per cent, respectively. The paper charts the development of drug use behaviour and some of the key results to date are presented. We have also identified a number of key areas ripe for analysis by interested researchers including sexual health and education. Conclusions: We have established a cohort with detailed data from adolescence to young adulthood, supplemented with parent and sibling reports and peer network data. The dataset, allowing for investigation of trajectories of adolescent substance use, associated factors and subsequent long-term outcomes, constitutes an important resource for longitudinal substance misuse research. A planned further wave as the cohort enter their late twenties and potential to link to administrative data sources, will further enrich the datasets

Contrasting effects of strong ties on SIR and SIS processes in temporal networks

Most real networks are characterized by connectivity patterns that evolve in time following complex, non-Markovian, dynamics. Here we investigate the impact of this ubiquitous feature by studying the Susceptible-Infected-Recovered (SIR) and Susceptible-Infected-Susceptible (SIS) epidemic models on activity driven networks with and without memory (i.e., Markovian and non-Markovian). We find that memory inhibits the spreading process in SIR models by shifting the epidemic threshold to larger values and reducing the final fraction of recovered nodes. In SIS processes instead, memory reduces the epidemic threshold and, for a wide range of diseases' parameters, increases the fraction of nodes affected by the disease in the endemic state. The heterogeneity in tie strengths, and the frequent repetition of strong ties it entails, allows in fact less virulent SIS-like diseases to survive in tightly connected local clusters that serve as reservoir for the virus. We validate this picture by studying both processes on two real temporal networks

Surgical management of ruptured small cerebral aneurysm: Outcome and surgical notes

Management of small aneurysms often poses a therapeutic dilemma and surgical treatment or coiling can be considered as therapeutic choices. In the present study, we reviewed our series of ruptured small cerebral aneurysm treated surgically