Cardiovascular magnetic resonance:Diagnostic utility and specific considerations in the pediatric population

Cardiovascular magnetic resonance is a non-invasive imaging modality which is emerging as important tool for the investigation and management of pediatric cardiovascular disease. In this review we describe the key technical and practical differences between scanning children and adults, and highlight some important considerations that must be taken into account for this patient population. Using case examples commonly seen in clinical practice, we discuss the important clinical applications of cardiovascular magnetic resonance, and briefly highlight key future developments in this field

Flexibility and rigidity of free boundary MHD equilibria

We study stationary free boundary configurations of an ideal incompressible magnetohydrodynamic fluid possessing nested flux surfaces. In 2D simply connected domains, we prove that if the magnetic field and velocity field are never commensurate, the only possible domain for any such equilibria is a disk, and the velocity and magnetic field are circular. We give examples of non-symmetric equilibria occupying a domain of any shape by imposing an external magnetic field generated by a singular current sheet charge distribution (external coils). Some results carry over to 3D axisymmetric solutions. These results highlight the importance of external magnetic fields for the existence of asymmetric equilibria.Comment: revised version. 18 pages, 3 figure

Method for correcting respiratory artefacts in parallel-accelerated first-pass myocardial perfusion imaging

Background Myocardial first-pass perfusion (MPI) requires singleshot imaging of multiple slices per cycle. Breath-holding supports advanced high-resolution MPI methods, but tolerance to respiratory motion is desirable. Respiratory misregistration can induce aliasing artefacts by inaccurate coil sensitivity calibration, particularly at higher acceleration factors and during stress hyperpnea. Coil calibration can be adapted for respiratory motion, but autocalibration (integrated”) methods limit acceleration, and temporal coil-calibration methods may reduce SNR or cause temporal smoothing. We evaluated a motiontracking modification of “prescan” parallel imaging specifically for MPI. Method

Comparison of 3 T and 1.5 T for T2* magnetic resonance of tissue iron.

BACKGROUND: T2* magnetic resonance of tissue iron concentration has improved the outcome of transfusion dependant anaemia patients. Clinical evaluation is performed at 1.5 T but scanners operating at 3 T are increasing in numbers. There is a paucity of data on the relative merits of iron quantification at 3 T vs 1.5 T. METHODS: A total of 104 transfusion dependent anaemia patients and 20 normal volunteers were prospectively recruited to undergo cardiac and liver T2* assessment at both 1.5 T and 3 T. Intra-observer, inter-observer and inter-study reproducibility analysis were performed on 20 randomly selected patients for cardiac and liver T2*. RESULTS: Association between heart and liver T2* at 1.5 T and 3 T was non-linear with good fit (R (2) = 0.954, p < 0.001 for heart white-blood (WB) imaging; R (2) = 0.931, p < 0.001 for heart black-blood (BB) imaging; R (2) = 0.993, p < 0.001 for liver imaging). R2* approximately doubled between 1.5 T and 3 T with linear fits for both heart and liver (94, 94 and 105 % respectively). Coefficients of variation for intra- and inter-observer reproducibility, as well as inter-study reproducibility trended to be less good at 3 T (3.5 to 6.5 %) than at 1.5 T (1.4 to 5.7 %) for both heart and liver T2*. Artefact scores for the heart were significantly worse with the 3 T BB sequence (median 4, IQR 2-5) compared with the 1.5 T BB sequence (4 [3-5], p = 0.007). CONCLUSION: Heart and liver T2* and R2* at 3 T show close association with 1.5 T values, but there were more artefacts at 3 T and trends to lower reproducibility causing difficulty in quantifying low T2* values with high tissue iron. Therefore T2* imaging at 1.5 T remains the gold standard for clinical practice. However, in centres where only 3 T is available, equivalent values at 1.5 T may be approximated by halving the 3 T tissue R2* with subsequent conversion to T2*