Moduli Stabilization and Supersymmetry Breaking in Deflected Mirage Mediation

We present a model of supersymmetry breaking in which the contributions from gravity/modulus, anomaly, and gauge mediation are all comparable. We term this scenario "deflected mirage mediation," which is a generalization of the KKLT-motivated mirage mediation scenario to include gauge mediated contributions. These contributions deflect the gaugino mass unification scale and alter the pattern of soft parameters at low energies. In some cases, this results in a gluino LSP and light stops; in other regions of parameter space, the LSP can be a well-tempered neutralino. We demonstrate explicitly that competitive gauge-mediated terms can naturally appear within phenomenological models based on the KKLT setup by addressing the stabilization of the gauge singlet field which is responsible for the masses of the messenger fields. For viable stabilization mechanisms, the relation between the gauge and anomaly contributions is identical in most cases to that of deflected anomaly mediation, despite the presence of the Kahler modulus. Turning to TeV scale phenomenology, we analyze the renormalization group evolution of the supersymmetry breaking terms and the resulting low energy mass spectra. The approach sets the stage for studies of such mixed scenarios of supersymmetry breaking at the LHC.Comment: 33 pages, 8 figures. Published version in Journal of High Energy Physic

Deflected Mirage Mediation: A Phenomenological Framework for Generalized Supersymmetry Breaking

We present a general phenomenological framework for dialing between gravity mediation, gauge mediation, and anomaly mediation. The approach is motivated from recent developments in moduli stabilization, which suggest that gravity mediated terms can be effectively loop suppressed and thus comparable to gauge and anomaly mediated terms. The gauginos exhibit a mirage unification behavior at a “deflected” scale, and gluinos are often the lightest colored sparticles. The approach provides a rich setting in which to explore generalized supersymmetry breaking at the CERN Large Hadron Collider

Cosmic Electroweak Strings

We examine the Standard Model field configurations near cosmic strings in a particular class of models. This class is defined by the condition that the generator of the flux in the string, $T_s$, commutes with the Standard Model Lie algebra. We find that if the Standard Model Higgs carries a charge $F_h /2$ under $T_s$, cosmic string solutions have Z-flux $\Phi_Z =[n-F_h N/F_{\phi}]4\pi \cos \theta_w /g$, where $n$ is any integer and $4\pi N/qF_{\phi}$ is the flux of the gauge field associated with $T_s$. Only the configuration with the smallest value of $|n-F_h N/F_{\phi}|$ is stable, however. We argue that the instabilities found at higher $\Phi_Z$ are just associated with paths in configuration space reducing $|n-F_h N/F_{\phi}|$ by one unit. This contradicts recent claims that the instabilities in such models represent the spontaneous generation of current along the string. We also show that the stable strings have no Standard Model fermion zero modes: therefore there is no possibility of supercurrents carried by Standard Model particles in this class of models.Comment: Latex, 13 pages, 2 uuencoded figure

Alert Notification System Router

The Alert Notification System Router (ANSR) software provides satellite operators with notifications of key events through pagers, cell phones, and e-mail. Written in Java, this application is specifically designed to meet the mission-critical standards for mission operations while operating on a variety of hardware environments. ANSR is a software component that runs inside the Mission Operations Center (MOC). It connects to the mission's message bus using the GMSEC [Goddard Space Flight Center (GSFC) Mission Services Evolution Center (GMSEC)] standard. Other components, such as automation and monitoring components, can use ANSR to send directives to notify users or groups. The ANSR system, in addition to notifying users, can check for message acknowledgements from a user and escalate the notification to another user if there is no acknowledgement. When a firewall prevents ANSR from accessing the Internet directly, proxies can be run on the other side of the wall. These proxies can be configured to access the Internet, notify users, and poll for their responses. Multiple ANSRs can be run in parallel, providing a seamless failover capability in the event that one ANSR system becomes incapacitated

Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy.

The success of immunotherapy has led to a myriad of clinical trials accompanied by efforts to gain mechanistic insight and identify predictive signatures for personalization. However, many immune monitoring technologies face investigator bias, missing unanticipated cellular responses in limited clinical material. We present here a mass cytometry (CyTOF) workflow for standardized, systems-level biomarker discovery in immunotherapy trials. To broadly enumerate immune cell identity and activity, we established and extensively assessed a reference panel of 33 antibodies to cover major cell subsets, simultaneously quantifying activation and immune checkpoint molecules in a single assay. This assay enumerates ≥98% of peripheral immune cells with ≥4 positively identifying antigens. Robustness and reproducibility are demonstrated on multiple samples types, across two research centers and by orthogonal measurements. Using automated analysis, we identify stratifying immune signatures in bone marrow transplantation-associated graft-versus-host disease. Together, this validated workflow ensures comprehensive immunophenotypic analysis and data comparability and will accelerate biomarker discovery

Fermionic massive modes along cosmic strings

The influence on cosmic string dynamics of fermionic massive bound states propagating in the vortex, and getting their mass only from coupling to the string forming Higgs field, is studied. Such massive fermionic currents are numerically found to exist for a wide range of model parameters and seen to modify drastically the usual string dynamics coming from the zero mode currents alone. In particular, by means of a quantization procedure, a new equation of state describing cosmic strings with any kind of fermionic current, massive or massless, is derived and found to involve, at least, one state parameter per trapped fermion species. This equation of state exhibits transitions from subsonic to supersonic regimes while the massive modes are filled.Comment: 27 pages, 15 figures, uses ReVTeX. Shortened version, accepted for publication in Phys. Rev.

NASA System Safety Handbook. Volume 2: System Safety Concepts, Guidelines, and Implementation Examples

This is the second of two volumes that collectively comprise the NASA System Safety Handbook. Volume 1 (NASASP-210-580) was prepared for the purpose of presenting the overall framework for System Safety and for providing the general concepts needed to implement the framework. Volume 2 provides guidance for implementing these concepts as an integral part of systems engineering and risk management. This guidance addresses the following functional areas: 1.The development of objectives that collectively define adequate safety for a system, and the safety requirements derived from these objectives that are levied on the system. 2.The conduct of system safety activities, performed to meet the safety requirements, with specific emphasis on the conduct of integrated safety analysis (ISA) as a fundamental means by which systems engineering and risk management decisions are risk-informed. 3.The development of a risk-informed safety case (RISC) at major milestone reviews to argue that the systems safety objectives are satisfied (and therefore that the system is adequately safe). 4.The evaluation of the RISC (including supporting evidence) using a defined set of evaluation criteria, to assess the veracity of the claims made therein in order to support risk acceptance decisions