Spherical pipe joint delivers loads equally to mating flange

Oxidizer inlet duct with a ball joint pipe fitting incorporating two spherical bearing races and balls in contact with centering cage springs transmits an evenly distributed load to the mating flange. This design should find application in piping systems where unequal load distributions exist

Spherical shield Patent

Flexible bellows joint shielding sleeve for propellant transfer pipeline

The State of Illinois Manufacturing

The strength of the manufacturing sector is fundamental to the overall economic performance of Illinois and the U.S. as a whole. The manufacturing sector in Illinois create large numbers of jobs that pay high wages to workers, purchases more goods and services from within the state than any other sector, and constitutes a main component of the state export economy. For these and other reasons, manufacturing needs be at the center of all government discussions on economic policy.The Center for Labor and Community Research (CLCR) was commissioned by the Illinois Manufacturers' Association to analyze the condition of the Illinois manufacturing sector. We found that Illinois manufacturing is essential to Illinois' economy, and although it is among the top manufacturing states in the country, it faces a number of challenges. This report demonstrates why and how Illinois manufacturing matters, explains the current challenges it faces, and recommends actions to overcome some of these challenges. In addition to looking at manufacturing as a whole, this report looks at four key manufacturing sectors, or clusters, that together account for 64% of manufacturing employment in the state. These are the metals, electrical, printing, and food manufacturing sectors.A few key findings that CLCR uncovered in this study include the following: Manufacturing is vital to the state's economy and workers. Manufacturing exports create significant employment opportunities in Illinois, and the state's manufacturing workers are the most productive in the nation by far.Like other U.S. states, Illinois faces increasing competition from low-wage producers in the developing world as well as from highly skilled producers in developed countries. In order to remain competitive into the future, the sector requires increased investments in its infrastructure and workers and an improved workforce development system in order to increase the value-added component of their products.The Illinois manufacturing sector needs a "High Road" partnership with government and labor to increase investment in infrastructure and workforce development, to support the sector by creating specialized service centers that provide assistance to Illinois companies, and to effectively using public subsidies to reward and assist those companies that are pursuing High Road strategies of innovation and development

Cross-spectral analysis of physiological tremor and muscle activity. I. Theory and application to unsynchronized EMG

We investigate the relationship between the extensor electromyogram (EMG) and tremor time series in physiological hand tremor by cross-spectral analysis. Special attention is directed to the phase spectrum and the effects of observational noise. We calculate the theoretical phase spectrum for a second order linear stochastic process and compare the results to measured tremor data recorded from subjects who did not show a synchronized EMG activity in the corresponding extensor muscle. The results show that physiological tremor is well described by the proposed model and that the measured EMG represents a Newtonian force by which the muscle acts on the hand.Comment: 9 pages, 6 figures, to appear in Biological Cybernetic

Characterization of three vasopressin receptor 2 variants: an apparent polymorphism (V266A) and two loss-of-function mutations (R181C and M311V).

Arginine vasopressin (AVP) is released from the posterior pituitary and controls water homeostasis. AVP binding to vasopressin V2 receptors (V2Rs) located on kidney collecting duct epithelial cells triggers activation of Gs proteins, leading to increased cAMP levels, trafficking of aquaporin-2 water channels, and consequent increased water permeability and antidiuresis. Typically, loss-of-function V2R mutations cause nephrogenic diabetes insipidus (NDI), whereas gain-of-function mutations cause nephrogenic syndrome of inappropriate antidiuresis (NSIAD). Here we provide further characterization of two mutant V2Rs, R181C and M311V, reported to cause complete and partial NDI respectively, together with a V266A variant, in a patient diagnosed with NSIAD. Our data in HEK293FT cells revealed that for cAMP accumulation, AVP was about 500- or 30-fold less potent at the R181C and M311V mutants than at the wild-type receptor respectively (and about 4000- and 60-fold in COS7 cells respectively). However, in contrast to wild type V2R, the R181C mutant failed to increase inositol phosphate production, while with the M311V mutant, AVP exhibited only partial agonism in addition to a 37-fold potency decrease. Similar responses were detected in a BRET assay for β-arrestin recruitment, with the R181C receptor unresponsive to AVP, and partial agonism with a 23-fold decrease in potency observed with M311V in both HEK293FT and COS7 cells. Notably, the V266A V2R appeared functionally identical to the wild-type receptor in all assays tested, including cAMP and inositol phosphate accumulation, β-arrestin interaction, and in a BRET assay of receptor ubiquitination. Each receptor was expressed at comparable levels. Hence, the M311V V2R retains greater activity than the R181C mutant, consistent with the milder phenotype of NDI associated with this mutant. Notably, the R181C mutant appears to be a Gs protein-biased receptor incapable of signaling to inositol phosphate or recruiting β-arrestin. The etiology of NSIAD in the patient with V266A V2R remains unknown

Business transformation towards sustainability

Sustainability is becoming increasingly important in today's corporate world and can contribute to the current and future success of organizations. Integrating ecological, social, and economic objectives into corporate decisions is a key success factor for transformation towards sustainability. As sustainability is not achieved by single actions, but rather is an on-going process, decision-makers must have means to analyze the current state of an organization. For this, we first illustrate how companies can structure the field of action for the transformation towards sustainability. Furthermore, we propose a decision model to determine how sustainability actions should be implemented in accordance with the paradigm of value-based management, i.e., considering their economic effects. We illustrate the application of the approach using the example of a German medium-sized company

Further evidence of the circulation of PMV-4 and influenza viruses with N2 - 1957 enzyme in migratory waterfowls

I n the years 1980—1984, one paramyxovirus type 4 and 11 influenza viruses were isolated from cloacal swabs collected from migratory waterfowls in Fed. Rep. Germany. One influenza virus of H4N8 subtype was isolated from swabs of commercial ducks collected at an abbatoir. Seven of 10 influenza strains, isolated from mallard clucks and coot were identified as a mixture of 2 —3 strains of H l , H4, and Ho subtype; 3 virus strains from the same locality relate antigenically to subtype H4 w i t h enzyme serologically identical with N2 — Singapore/57 as demonstrated by means of polyclonal and monoclonal antibody

La ley de herodes: Tendencias del cine mexicano actual

_Se examinan algunas tendencias del cine mexicano contemporáneo, la primera de las cuales consiste en la siempre latente posibilidad de censura, respecto de la cual el gobierno ya no tiene el monopoloio de la tentación autoritaria; la seguna es la continuidad del género de comedia light, la tercera es la abundancia de filmes cuya temática es el crimen organizado, particularmente el narcotráfico

Increased Expression of Cell-Cell Signaling Genes by Stimulated Mononuclear Leukocytes in Patients with Previous Atherothrombotic Stroke A Whole Genome Expression Profile Study

Background/Aims: Inflammation plays an important role in atherosclerosis and stroke. Acute infections are recognized as trigger factors for ischemic stroke. Methods: In this whole genome expression profile study of 15 patients and 15 control subjects, we tested the hypothesis that patients with a history of atherothrombotic stroke show enhanced transcription of inflammatory genes in circulating leukocytes. RNA from unstimulated or lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs) was analyzed with Affymetrix U133A GeneChips using a pooling design. Expression of single genes and functional groups of genes was analyzed by global statistical tests. Results: A total of 10,197 probe sets showed positive calls. After correction for multiple testing no single probe set revealed significant differences either without or with LPS stimulation. However, significant global expression differences were found upon LPS stimulation for the group of genes that are involved in cell-cell signaling. Conclusion: LPS stimulation of PBMCs, a condition mimicking bacterial infection, induces differential expression of a group of cell-cell signaling genes in patients with previous atherothrombotic stroke. This finding can be caused by genetic differences between both groups, but acquired risk factors, medication and technical factors may also have contributed to the result. Copyright (C) 2009 S. Karger AG, Base