Oxidation-resistant coatings for refractory metals used in inert atmospheres

Test conditions and results are reported for various coatings on a 1 percent zirconium columbium alloy at a temperature of 2000 deg F. Molybdenum silicide over molybdenum is most effective coating, tin-aluminum coating is adequately protective, chromium-molybdenum silicides are not protective

Secured Credit and Bankruptcy: A Call for the Federalization of Personal Property Security Law

In recent years, the need for systems monitoring the current in ation pressure in pneumatic tires has grown dramatically. One way to monitor the in ation pressure is to use the fact that the tire reacts like a spring when excited from road roughness. The resonance frequency of the tire can be estimated with standard signal processing procedures. Three different approaches for vibration analysis are studied using a simulation model similar to the tire model. The first approach uses the raw wheel speed which is highly over-sampled. In the second approach a pre-filter is used to remove the disturbances and the third approach uses down sampling to isolate the vibration frequency. Especially bias in the estimation is studied

Workmanship standards for fusion welding

Workmanship standards manual defines practices, that adhere to rigid codes and specifications, for fusion welding of component piping, assemblies, and systems. With written and pictorial presentations, it is part of the operating procedure for fusion welding

High temperature resistant cermet and ceramic compositions

Cermet compositions having high temperature oxidation resistance, high hardness and high abrasion and wear resistance, and particularly adapted for production of high temperature resistant cermet insulator bodies are presented. The compositions are comprised of a sintered body of particles of a high temperature resistant metal or metal alloy, preferably molybdenum or tungsten particles, dispersed in and bonded to a solid solution formed of aluminum oxide and silicon nitride, and particularly a ternary solid solution formed of a mixture of aluminum oxide, silicon nitride and aluminum nitride. Also disclosed are novel ceramic compositions comprising a sintered solid solution of aluminum oxide, silicon nitride and aluminum nitride

Metal-to-ceramic seals - A literature survey

Survey of unclassified literature furthers design and development of nuclear thermionic converter seals. Data cover topics which are particularly relevant to thermionics. Data are reviewed and review discussion is presented along with summary of earlier work

Metal-to-ceramic seals for thermionic converters - A literature survey

Metal to ceramic sealing techniques for thermionic converters - literature surve

Tailoring Targeted Therapy to Individual Patients: Lessons to be Learnt from the Development of Mitomycin C

The modern era of targeted therapeutics offers the potential to tailor therapy to individual patients whose tumours express a specific target. Previous attempts to forecast tumour response to conventional chemotherapeutics based on similar principles have however been disappointing. Mitomycin C (MMC), for example, is a bioreductive drug that requires metabolic activation by cellular reductases for activity. The enzyme NAD(P)H:Quinone oxidoreductase-1 (NQO1) can reduce MMC to DNA damaging species but attempts to establish the relationship between tumour response to MMC and NQO1 expression have generated conflicting reports of good and poor correlations. Several other reductases are known to activate MMC. This, in conjunction with the fact that various physiological and biochemical factors influence therapeutic response, suggests that the mechanism of action of MMC is too complex to allow tumour response to be predicted on the basis of a single enzyme. Alternative approaches using more complex biological and pharmacological systems that reflect the spectrum of reductases present within the tumour have been developed and it remains to be seen whether or not the predictive value of these approaches is enhanced. With regards to targeted therapeutics, the experience with MMC suggests that prediction of tumour response based on analysis of a single target may be too simplistic. Multiple mechanisms of action and the influence of tumour microenvironment on cell biology and drug delivery are likely to influence the final outcome of therapy. The challenge for the future progression of this field is to develop assays that reflect the overall biological and pharmacological processes involved in drug activation whilst retaining the simplicity and robustness required for routine chemosensitivity testing in a clinical setting