120 research outputs found

    Production and characterization of spray-dried theophylline powders prepared from fresh milk for potential use in paediatrics

    Get PDF
    "This is the accepted version of the following article: Production and characterization of spray-dried theophylline powders prepared from fresh milk for potential use in paediatrics (2017). J Pharm Pharmacol, 69: 554–566, which has been published in final form at http://dx.doi.org/10.1111/jphp.12612 . This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [http://olabout.wiley.com/WileyCDA/Section/id-820227.html]."Objective: This work evaluates the potential of using fresh milk to deliver theophylline to children.Methods: Theophylline–fresh milk systems were prepared using different solids ratios (0 : 1–1 : 0) and three fat contents in commercial milks (low, medium and high), which were spray-dried at different inlet air temperatures (Tinlet – 105, 130 and 150 °C). The process was evaluated for yield and the resulting powders for moisture content (MC), particle size and shape, density and wettability. Theophylline–milk potential interactions (differential scanning calorimetry (DSC) and FT-IR) and chemical (theophylline content) and microbiological stability of powders (shelf and in-use) were also evaluated.Key Findings: The production yield (13.6–76.0%), MC (0.0–10.3%) and contact angles in water (77.29–93.51°) were significantly (P < 0.05) affected by Tinlet, but no differences were found concerning the mean particle size (3.0–4.3 μm) of the different powders. The milk fat content significantly (P < 0.05) impacted on the density (1.244–1.552 g/cm3). Theophylline content remained stable after 6 months of storage, before extemporaneous reconstitution. After reconstitution in water, low-fat milk samples (stored at 4 °C) met the microbial pharmacopoeia criteria for up to 7 days. No theophylline–milk components interaction was observed.Conclusion: Spray-dried milk-composed powders may be used as vehicles for theophylline delivery in paediatrics following further characterization and in-vivo evaluation.info:eu-repo/semantics/publishedVersio

    Acrylamide formation and quality properties of chitosan based batter formulations

    Full text link
    [EN] The potential of chitosan to mitigate acrylamide formation has been already demonstrated. The two main objectives of this study were: 1) to select the most adequate degree of deacetylation (DD) and molecular weight (Mw) of chitosan based on acrylamide mitigation criteria and 2) to evaluate the influence of including chitosan in batter formulations on some important technological parameters of raw batters (flow behavior and water retention capacity) and on some quality properties of fried batters (oil uptake, color and texture). Results in model systems showed that chitosans with higher deacetylation degree (86.5 and 92.8%) achieved a decrease of acrylamide between 44 and 81%, depending on reaction time, compared to the control (without chitosan). Furthermore, acid hydrolysis process of chitosan was found to negatively affect its inhibitory effect on acrylamide formation independently of the molecular weight. Raw chitosan based batter formulations presented higher consistency and water retention capacity than the control; chitosan addition to batters reduced the hardening of the fried samples during the post-frying cooling period. No significant differences in water loss were observed between batters with or without added chitosan; however, chitosan-batter formulations showed lower oil uptake during frying as compared to control samples.The authors thank the gs1:Universitat Politecnica de Valencia for the PhD scholarship given to Mariola Sansano Tomas.Sansano Tomás, M.; Castelló Gómez, ML.; Heredia Gutiérrez, AB.; Andrés Grau, AM. (2016). Acrylamide formation and quality properties of chitosan based batter formulations. Food Hydrocolloids. 66:1-7. doi:10.1016/j.foodhyd.2016.10.019S176

    Factors affecting browning and crystallisation of palm syrup and palm sugar cake

    No full text
    Doctor of Philosophy (Food Technology), 201

    Spatio-temporal State Space Model Estimation for Smart structures

    No full text
    EThOS - Electronic Theses Online ServiceGBUnited Kingdo

    INFLUENCE OF PACKAGING MATERIAL AND STORAGE TIME ON PHYSICAL, CHEMICAL AND MICROBIOLOGICAL PROPERTIES OF SET YOGURT: A COMPARATIVE STUDY BETWEEN MODIFIED BIODEGRADABLE POLY(LACTIC ACID) AND POLYPROPYLENE

    No full text
    The current paper investigates the influence of storage time and type of polymeric packaging material on the chemical, physical and microbiological properties of set yogurt. Firstly, poly(lactic acid) (PLA) was modified by using a core-shell rubber (CSR) and an acrylic processing aid (PA) to produce PLA with high toughness and good processability. Secondly, an appropriate PLA/PA/CSR composition was selected and fabricated to yogurt cup. The yogurt was stored in both modified PLA and polypropylene (PP) packages to observe some physical, chemical and biological changes. Finally, the biodegradation test was made on both packages and compared with that cellulose. Experimental results revealed that adding 5wt% CSR gave PLA/PA as tough as PP. Types of packaging material and storage time did not change the color of yogurt. The number of lactic acid bacteria grew significantly after they had been incubated for 6 days. The bacterial viability decreased dramatically due to the increased acidity and the decreased pH. A positive impact on the viability of bacterial growth was found when yogurt was stored in modified PLA package. This made yogurt had more health benefits than stored in PP package. The biodegradation test results indicated that the modified PLA degraded at a rapid rate. It achieved approximately 50% biodegradation within 40 days which was comparable to the time required to degrade the cellulose, whereas PP was non-biodegradable over the period studied. In summary, substitution conventional PP by a novel modified PLA seems to be a better way for both the health and the environment benefits
    corecore