Sensory profile of portuguese white wines using long-term memory: a novel nationwide approach

White wine sensory profiling of all 12 Protected Geographical Indications (PGIs) of mainland Portugal was achieved through completion of extended sensory questionnaires by 20 professional wine experts. No samples were assessed; the experiment was based on memory alone. Three macro-zonings were found and typicality differences were statistically validated and sensory described. PGI MINHO was found the most typical of all PGIs, with several extreme rates on Color, Aroma and Taste. SOUTHERN cluster of the four meridional PGIs presented several extreme, therefore typical, sensory assessments, mostly opposite to the profile of PGI Minho. Color tonality, alcohol and acidity were mutually related and respective variations were correlated with published findings and expressed as key factors for regional macro-zoning differentiation. Moreover, with the proposed methodology it was possible to achieve a novel nationwide sensory characterization of PGIs, overcoming ongoing macroscaling and sample representativeness limitations and envisaging new nation-sized sensory studiesinfo:eu-repo/semantics/publishedVersio

La formación de capacidades orientada a la gestión de la innovación en el vínculo universidad-empresa: caso Guantánamo

The article that is presented from the methodological conception that it assumes, presents a renewed look at the university-company link in the Guantanamo context, where capacity building and innovation management centralize the relationships in the work system as nuclei. For this, the proposed conception models a system of procedures that revealed satisfactory results in its practical expression, for which research methods and techniques were taken into account that, in addition to recognizing the current state, allowed to guide the proposal, so that it contributes from the strategic design of the work system to the formation of capacities based on innovation management.El artículo se presenta desde la concepción metodológica que asume una mirada renovada del vínculo universidad–empresa, en el contexto guantanamero, donde la formación de capacidades y la gestión de innovación centralizan como núcleos las relaciones en el sistema de trabajo. La concepción propuesta modela un sistema de procedimientos que reveló resultados satisfactorios en su expresión práctica, para lo cual se tuvo en cuenta métodos y técnicas de investigación que, además, de reconocer el estado actual permitió orientar la propuesta, de modo que se contribuya desde el diseño estratégico del sistema de trabajo a la formación de capacidades en función de la gestión de innovación

CAESAR models for developmental toxicity

<p>Abstract</p> <p>Background</p> <p>The new REACH legislation requires assessment of a large number of chemicals in the European market for several endpoints. Developmental toxicity is one of the most difficult endpoints to assess, on account of the complexity, length and costs of experiments. Following the encouragement of QSAR (<it>in silico</it>) methods provided in the REACH itself, the CAESAR project has developed several models.</p> <p>Results</p> <p>Two QSAR models for developmental toxicity have been developed, using different statistical/mathematical methods. Both models performed well. The first makes a classification based on a random forest algorithm, while the second is based on an adaptive fuzzy partition algorithm. The first model has been implemented and inserted into the CAESAR on-line application, which is java-based software that allows everyone to freely use the models.</p> <p>Conclusions</p> <p>The CAESAR QSAR models have been developed with the aim to minimize false negatives in order to make them more usable for REACH. The CAESAR on-line application ensures that both industry and regulators can easily access and use the developmental toxicity model (as well as the models for the other four endpoints).</p

Global QSAR models of skin sensitisers for regulatory purposes

Abstract Background The new European Regulation on chemical safety, REACH, (Registration, Evaluation, Authorisation and Restriction of CHemical substances), is in the process of being implemented. Many chemicals used in industry require additional testing to comply with the REACH regulations. At the same time EU member states are attempting to reduce the number of animals used in experiments under the 3 Rs policy, (refining, reducing, and replacing the use of animals in laboratory procedures). Computational techniques such as QSAR have the potential to offer an alternative for generating REACH data. The FP6 project CAESAR was aimed at developing QSAR models for 5 key toxicological endpoints of which skin sensitisation was one. Results This paper reports the development of two global QSAR models using two different computational approaches, which contribute to the hybrid model freely available online. Conclusions The QSAR models for assessing skin sensitisation have been developed and tested under stringent quality criteria to fulfil the principles laid down by the OECD. The final models, accessible from CAESAR website, offer a robust and reliable method of assessing skin sensitisation for regulatory use.</p

La Notion de transcendance , son sens, son évolution

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Use of neighborhood and stratification approaches to speed up instance selection algorithms

International audienc

Use of neighborhood and stratification approaches to speed up instance selection algorithms

International audienc