Clinical features of alcoholic hepatitis in latinos and caucasians: A single center experience.

AimTo study differences of presentation, management, and prognosis of alcoholic hepatitis in Latinos compared to Caucasians.MethodsWe retrospectively screened 876 charts of Caucasian and Latino patients who were evaluated at University of California Davis Medical Center between 1/1/2002-12/31/2014 with the diagnosis of alcoholic liver disease. We identified and collected data on 137 Caucasians and 64 Latinos who met criteria for alcoholic hepatitis, including chronic history of heavy alcohol use, at least one episode of jaundice with bilirubin ≥ 3.0 or coagulopathy, new onset of liver decompensation or acute liver decompensation in known cirrhosis within 12 wk of last drink.ResultsThe mean age at presentation of alcoholic hepatitis was not significantly different between Latinos and Caucasians. There was significant lower rate of overall substance abuse in Caucasians compared to Latinos and Latinos had a higher rate of methamphetamine abuse (12.5% vs 0.7%) compared to Caucasians. Latinos had a higher mean number of hospitalizations (5.3 ± 5.6 vs 2.7 ± 2.7, P = 0.001) and mean Emergency Department visits (9.5 ± 10.8 vs 4.5 ± 4.1, P = 0.017) for alcohol related issues and complications compared to Caucasians. There was significantly higher rate of complications of portal hypertension including gastrointestinal bleeding (79.7% vs 45.3%, P < 0.001), spontaneous bacterial peritonitis (26.6% vs 9.5%, P = 0.003), and encephalopathy (81.2% vs 55.5%, P = 0.001) in Latinos compared to Caucasians.ConclusionLatinos have significant higher rates of utilization of acute care services for manifestations alcoholic hepatitis and complications suggesting poor access to outpatient care

Ultrasound for improving the preservation of chicken meat

<div><p>Abstract The objective of this study was to evaluate the effect of power ultrasound on the microbiota of chicken meat. Samples were treated under the following conditions of frequency and power: 20 kHz and 27.6 W/cm2; 40 kHz and 10.3 W/cm2; 850 kHz and 24.1 W/cm 2. Microbial counts were done before the ultrasound treatment, immediately after and following 7 days of aerobic storage at 4 °C. The results indicate that high intensity ultrasound helps inhibit the growth of lactic acid, mesophilic and psychrophilic bacteria present in chicken meat at the ultrasound frequency levels used in this study. The number of mesophilic bacteria decreased with the ultrasound probe at 20 kHz and 27.6 W/cm2 in relation to the treatment with higher frequency and less intensity. In conclusion, high-intensity ultrasound has a bactericidal effect. Therefore, it can be useful in the preservation of meat products and thus play an important role in the food industry.</p></div

Cellular catabolism of the iron-regulatory peptide hormone hepcidin.

Hepcidin, a 25-amino acid peptide hormone, is the principal regulator of plasma iron concentrations. Hepcidin binding to its receptor, the iron exporter ferroportin, induces ferroportin internalization and degradation, thus blocking iron efflux from cells into plasma. The aim of this study was to characterize the fate of hepcidin after binding to ferroportin. We show that hepcidin is taken up by ferroportin-expressing cells in a temperature- and pH-dependent manner, and degraded together with its receptor. When Texas red-labeled hepcidin (TR-Hep) was added to ferroportin-GFP (Fpn-GFP) expressing cells, confocal microscopy showed co-localization of TR-Hep with Fpn-GFP. Using flow cytometry, we showed that the peptide was almost completely degraded by 24 h after its addition, but that lysosomal inhibitors completely prevented degradation of both ferroportin and hepcidin. In addition, using radio-labeled hepcidin and HPLC analysis we show that hepcidin is not recycled, and that only degradation products are released from the cells. Together these results show that the hormone hepcidin and its receptor ferroportin are internalized together and trafficked to lysosomes where both are degraded

Numérisation des manuscrits médiévaux : le projet européen BAMBI

Colloque: Vers une nouvelle érudition : numérisation et recherche en histoire du livre, Rencontres Jacques Cartier, Lyon, décembre 1999

A trajectory generation and system characterization model for cislunar low-thrust spacecraft. Volume 2: Technical manual

The documentation of the Trajectory Generation and System Characterization Model for the Cislunar Low-Thrust Spacecraft is presented in Technical and User's Manuals. The system characteristics and trajectories of low thrust nuclear electric propulsion spacecraft can be generated through the use of multiple system technology models coupled with a high fidelity trajectory generation routine. The Earth to Moon trajectories utilize near Earth orbital plane alignment, midcourse control dependent upon the spacecraft's Jacobian constant, and capture to target orbit utilizing velocity matching algorithms. The trajectory generation is performed in a perturbed two-body equinoctial formulation and the restricted three-body formulation. A single control is determined by the user for the interactive midcourse portion of the trajectory. The full spacecraft system characteristics and trajectory are provided as output

L'ananas en Côte d'Ivoire

La Côte d'Ivoire a atteint une échelle internationale pour l'exportation en ananas frais et pour la production de conserves (200.000 t). Zones de production et leurs caractéristiques ecologiques (le quart Sud-est). Techniques culturales. Marchés. Commercialisation. Perspectives d'amélioration de la qualité, des plantations, du transport, du commerce. Côte-d'Ivoir

Design of Spacecraft Missions to Remove Multiple Orbital Debris Objects

The amount of hazardous debris in Earth orbit has been increasing, posing an evergreater danger to space assets and human missions. In January of 2007, a Chinese ASAT test produced approximately 2600 pieces of orbital debris. In February of 2009, Iridium 33 collided with an inactive Russian satellite, yielding approximately 1300 pieces of debris. These recent disastrous events and the sheer size of the Earth orbiting population make clear the necessity of removing orbital debris. In fact, experts from both NASA and ESA have stated that 10 to 20 pieces of orbital debris need to be removed per year to stabilize the orbital debris environment. However, no spacecraft trajectories have yet been designed for removing multiple debris objects and the size of the debris population makes the design of such trajectories a daunting task. Designing an efficient spacecraft trajectory to rendezvous with each of a large number of orbital debris pieces is akin to the famous Traveling Salesman problem, an NP-complete combinatorial optimization problem in which a number of cities are to be visited in turn. The goal is to choose the order in which the cities are visited so as to minimize the total path distance traveled. In the case of orbital debris, the pieces of debris to be visited must be selected and ordered such that spacecraft propellant consumption is minimized or at least kept low enough to be feasible. Emergent Space Technologies, Inc. has developed specialized algorithms for designing efficient tour missions for near-Earth asteroids that may be applied to the design of efficient spacecraft missions capable of visiting large numbers of orbital debris pieces. The first step is to identify a list of high priority debris targets using the Analytical Graphics, Inc. SOCRATES website and then obtain their state information from Celestrak. The tour trajectory design algorithms will then be used to determine the itinerary of objects and v requirements. These results will shed light on how many debris pieces can be visited for various amounts of propellant, which launch vehicles can accommodate such missions, and how much margin is available for debris removal system payloads

Diffusion et migration de l'eau polluée le long des plages belges: nouvelle expérience avec rejet de 100 kg de rhodamine B: conclusions préliminaires

A solution of one hundred kilograms of B rhodamine was introduced in a sewer which discharges into the sea. The dispersion of the discharge was observed and located by means of 4 optical theodolites and by air photographs. Water samples were collected in the coloured plume and on its boundaries during a whole tidal cycle. They were analysed by spectrofluorimetry. The results demonstrate the complexity of the factors that affect water movements. The drift seems to be mainly due to the wind. The predominating winds contribute to maintain the waste water closely to the water line over a distance of several miles