49,491 research outputs found
Monitoring of Iberian wolf expansion in Sabugal: Malcata Region
Relatório de projecto no âmbito de Bolsa Universidade de Lisboa/Fundação Amadeu Dias (2008/2009)Departamento de Biologia Animal, Faculdade de Ciências da Universidade de LisboaScholarship Fundação Amadeu Dias/Universidade de LisboaWind farm construction may cause an effect of repulse on the wildlife. Sabugal – Malcata region has a new
wind farm in a zone where the situation of the Iberian wolf (Canis lupus signatus, Cabrera 1907) is considered as
precarious. In this context a monitoring project was begun to assess the impact of this infrastructure on the Iberian wolf
population. Here are presented the results of eight months of monitoring and some information received during the
project about the wolf presence in this region. Every month, signs of wolf presence were prospected in twelve transects
in the wind farm adjacent area and fourteen inquires were done to people that can contact with this predator. In all the
eight months only two scats were detected and two wolf tracks after a snowfall. The presence of wolves was referred in
the inquires as constant before 1990. However, some recent livestock damages were reported. The Roe deer
(Capreolus capreolus) seems to be in expansion in this area, being reported in more than half of the inquires. This
situation may reveal a new opportunity for settlement of dispersing wolves. The occurrence of the Iberian Wolf in
Sabugal – Malcata region continues not to be confirmed, but the designation of probable presence is reinforced.Universidade de Lisboa; Fundação Amadeu Dia
Human Dimensions of Marine Fisheries: Using GIS to Illustrate Land-Sea Connections in the Northeast U.S. Herring, Clupea harengus, Fishery
Geographic Information Systems can help improve ocean literacy and inform our understanding of the human
dimensions of marine resource use. This paper describes a pilot project where GIS is used to illustrate the connections between fish stocks and the social, cultural, and economic components of the fishery on land. This method of presenting and merging qualitative and quantitative data represents a new approach to assist fishery managers,
participants, policy-makers, and other stakeholders in visualizing an often confusing and poorly understood web of interactions. The Atlantic herring fishery serves as a case study and maps from this pilot project are presented and methods reviewed
Using Cost Observation to Regulate Bureaucratic Firms
We study regulation of a bureaucratic provider of a public good in the presence of moral hazard and adverse selection. By bureaucratic we mean that it values output in itself, and not only profit. Three different financing systems are studied - cost reimbursement, prospective payment, and the optimal contract. In all cases, the output level increases with the bureaucratic bias. We find that the optimal contract is linear in cost (fixed payment plus partial cost-reimbursement). A stronger preference for high output reduces the tendency of the firm to announce a high cost (adverse selection), allowing a more powered incentive scheme (a lower fraction of the costs is reimbursed), which alleviates the problem of moral hazard.Procurement, Regulation, Adverse selection, Moral hazard, Bureaucracy
The determinants of success in university entrance
This paper proposes that high school graduates applying to higher education institutions do not have equal chances of succeeding. Therefore, admission outcomes must be taken into account by researchers and policy makers analysing college-going behaviour and the equity and efficiency of higher education systems.Educational economics, higher education, chances of success
Regulating a monopolist with unknown bureaucratic tendencies
We determine the optimal contract for the regulation of a bureaucratic firm in the case in which the bureaucratic bias is firm's private information. We find that output is distorted upward when the bureaucratic bias is low, downward when it is high, and equals a reference output when it is intermediate (in this case, the participation constraint is binding). We also determine an endogenous reference output (equal to the expected output, which depends on the reference output), and find that the response of output to cost is null in the short-run (in which the reference output is fixed) whenever the managers' types are in the intermediate range and negative in the long-run (after the adjustment of the reference output to equal expected output).Procurement, Regulation, Adverse selection, Bureaucracy, Reservation utility
Early Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic Mice
Frontotemporal Dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two neurodegenerative diseases associated to mislocalization and aggregation of TAR DNA-binding protein 43 (TDP-43). To investigate in depth the behavioral phenotype associated with this proteinopathy, we used as a model transgenic (Tg) mice conditionally overexpressing human wild-type TDP 43 protein (hTDP-43-WT) in forebrain neurons. We previously characterized these mice at the neuropathological level and found progressive neurodegeneration and other features that evoke human TDP-43 proteinopathies of the FTD/ALS spectrum. In the present study we analyzed the behavior of mice at multiple domains, including motor, social and cognitive performance. Our results indicate that young hTDP-43-WT Tg mice (1 month after post-weaning transgene induction) present a normal motor phenotype compared to control littermates, as assessed by accelerated rotarod performance, spontaneous locomotor activity in the open field test and a mild degree of spasticity shown by a clasping phenotype. Analysis of social and cognitive behavior showed a rapid installment of deficits in social interaction, working memory (Y-maze test) and recognition memory (novel object recognition test) in the absence of overt motor abnormalities. To investigate if the motor phenotype worsen with age, we analyzed the behavior of mice after long-term (up to 12 months) transgene induction. Our results reveal a decreased performance on the rotarod test and in the hanging wire test, indicating a motor phenotype that was absent in younger mice. In addition, long-term hTDP-43-WT expression led to hyperlocomotion in the open field test. In sum, these results demonstrate a time-dependent emergence of a motor phenotype in older hTDP-43-WT Tg mice, recapitulating aspects of clinical FTD presentations with motor involvement in human patients, and providing a complementary animal model for studying TDP-43 proteinopathies.Fil: Alfieri, Julio Armando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Silva Pinto, Pablo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Müller Igaz, Lionel Ivan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentin
Guardare oltre il tempo
È nostra convinzione che gli argomenti della dissoluzione del luogo contribuiscono a ideare una
città che va aggiungendo architetture atopici, architetture dove si può manifestare più facilmente
la spettacolarità delle sue forme, e dove la rottura spaziale della città diventa più evidente.
D'altra parte, la difesa dell’anti-storicità del processo creativo architettonico, nel confronto con la
città e la sua architettura in nome del progresso e del futuro, crea le forme di rottura e di disagio
e dà forza ad una nuova visione puramente funzionalista. Oggi l'architettura appare come
controllata d’altre aree del sapere, manifestandosi, tuttavia, esuberante nelle sue forme, in
un’autonomia illusoria, e prigioniera di presupposti che le superano e svalutano. L'architettura
contemporanea deve chiamare di nuovo a sé il concetto di continuità e permanenza, della
prospettiva di creare nuove memorie e di contribuire alla definizione di riferimenti collettivi che
possano edificare le forme della nostra storia attuale, e le forme di una città in crescita che oggi
è già difficile da identificare. Siamo preoccupati, tuttavia, in un altro ordine, l'ordine che
possiamo trovare attraverso esempi che mostrano una sequenza 'genomica', una struttura che
stabilisca la continuità dei fatti che hanno determinato la città e che la hanno configurato in molti
modi, nel corso della sua storia. In un processo dicotomico di causa ed effetto, la città
contemporanea può anche vedere la sua forma descritta con la precisazione della forma dei
suoi spazi pubblici (Il suo design e la sua posizione – una grammatica operativa), ma anche con
il rapporto e i legami tra loro, (un ordine – una sintassi efficiente).We are convinced that the arguments surrounding the dissolution of place tend toward the
materialization of a city which continues to amass atopic architectures, architectures that
facilitate the spectacularism of their forms and where the spatial rupture of the city becomes
more discernible. On the other hand, the vindication of the architectural creative process as
anti-historical creates forms of rupture and discomfort, and empowers a new, merely
functionalist, vision. Today architecture is seen as subsidiary to other branches of knowledge,
and, despite its exuberant forms, it retains an illusory autonomy, confined by assumptions that
surpass and depreciate it. Contemporary architecture must reclaim the notion of perpetuity and
permanence, so as to create new memories and contribute to the maintenance of collective
references that solidify our current history’s forms and the forms of a growing city increasingly
difficult to identify. We are interested in the order that we can find by way of examples that
feature a ‘genomic’ sequence, a structure capable of establishing the continuity of facts that
throughout history have determined and configured the city in so many ways. By means of a dichotomous cause and effect process, we may also describe the contemporary city’s form by
clarifying the form of public spaces (their design and position – an operative grammar) and the
relation and articulation between public spaces (an order – an efficient syntax).Peer Reviewe
Situação formativa : um instrumento de gestão do currículo capaz de promover literacia científica
Com este trabalho pretende-se apresentar os resultados obtidos na primeira fase de um estudo que visa conhecer as potencialidades do instrumento de planificação e gestão curricular “Situação Formativa” para promover, em dois grupos de professores do Ensino Básico (um em inicio de carreira e outro com cerca de 11 anos de serviço), percepções adequadas sobre a Ciência, a Tecnologia e suas relações com a Sociedade (CTS). Para além do enquadramento do trabalho, apresentam-se a metodologia e os instrumentos adoptados, exemplo de dados recolhidos e sua análise, bem como algumas conclusões
Privacidade da pessoa humana no ambiente de trabalho: a (in)violabilidade do correio eletrônico
The main reason for fundamental rights is mainly preserve aspects of human dignity, which finds as corollary the right to privacy. Meanwhile, through the broad and sneaky development of new technologies, the right to privacy has experienced severe violations and restrictions because of (in)correct conjugation with other goods and rights, also constitutionally protected. In the workplace is that the protection of the right to privacy has expressed its legal pathologies. According to the Brazilian law, the right to privacy is regarded not only as a fundamental right, but also, admittedly, as a right of personality while projections of constitutional protection emphatic in the field of private law. This happens, principally, due to the phenomenon of "constitutionalization of private law" or "devaluation of patrimony" and replacement of the human person and his emanations for the center of private's concern. The change in perspective according to which the person valley by it is and not for what have, it difficult to apply in the context of labor relations, in particular in the use of electronic mail in the workplace. There is not specific legislation regulating the use of new technologies in the workplace, and in the doctrine there is no consensus on the issue. The Brazilian Labor Court in some judged builds the legal interpretation of a vulnerability's right to privacy, bringing longings of USA’s law to the Brazilian legal reality, without establishing a necessarily comparison enlightening to find consensus and incompatibilities. In the present study, therefore, taking as North Article 8 of the Consolidation of Brazilian Labor Laws, will analyze how Brazilian law, in comparative perspective to the USA’s model, responds to the problem arising from the use of electronic mail in the workplace.A razão de ser dos direitos fundamentais é preservar aspectos essenciais à dignidadedo indivíduo, que encontra como corolário o direito à privacidade. Entrementes, através do amplo e sorrateiro desenvolvimento das novas tecnologias, o direito à privacidade tem experimentado severas violações e restrições em face da (in) correta conjugação com outros bens e direitos, também constitucionalmente protegidos. No ambiente de trabalho, a tutela do direito à privacidade tem externado as suas patologias jurídicas. No âmbito do ordenamento jurídico brasileiro, o direito à privacidade é tido não só como um direito fundamental, mas também, reconhecidamente, como um direito de personalidade, como projeção de uma tutela constitucional enfática no campo do direito privado. Isso se deve, principalmente, ao fenômeno da constitucionalização ou despatrimonialização do direito privado e a recolocação da pessoa humana e as suas emanações ao centro da preocupação privatista. A mudança de perspectiva, segundo a qual a pessoa vale pelo que é e não pelo que tem, vem encontrando dificuldades de aplicação no âmbito das relações laborais, em especial, no que diz com o uso do correio eletrônico no trabalho. Não há legislação específica disciplinando o uso das novas tecnologias no ambiente laboral, sendo que, na doutrina, não se encontra consenso sobre o tema.A jurisprudência laboral brasileira, em alguns julgados, constrói a interpretação jurídica de uma vulnerabilidade do direito à privacidade, trazendo anseios do direito estadunidense à realidade jurídica brasileira, sem necessariamente, estabelecer uma comparação esclarecedora ao estabelecimento de confluências e incompatibilidades. Na presente pesquisa, portanto, tomando como norte o artigo 8º da CLT, analisar-se-á de que forma o direito brasileiro, em cotejo com o modelo estadunidense, responde ao problema decorrente do uso do correio eletrônico no ambiente de trabalho
Nanopartículas lipídicas: aplicações cosméticas
Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências FarmacêuticasTendo em conta a sua composição e as vantagens que apresentam, as nanopartículas lipídicas têm sido amplamente aplicadas em cosmetologia, existindo atualmente vários produtos comercializados. Deste modo, a análise das potencialidades destes sistemas para novas aplicações cosméticas é essencial.
Neste trabalho é efetuada uma revisão bibliográfica relativa aos diferentes produtos cosméticos contendo nanopartículas lipídicas, quer estes se encontrem em fase de estudo ou já disponíveis no mercado.
Na primeira parte do trabalho é feita uma breve introdução acerca da estrutura da pele, da definição de produtos cosméticos e das suas principais caraterísticas e aplicações. Na segunda parte são descritos os sistemas de nanopartículas lipídicas, tendo em conta as suas caraterísticas estruturais, diferentes aplicações em cosmetologia e são dados exemplos dos produtos cosméticos existentes no mercado. According to their composition and advantages, lipid nanoparticles have been widely applied in cosmetology, and there are several products that can be found on the market nowadays. Therefore, the analysis of the potential of these new systems for cosmetic applications is essential.
In this work is performed a literature review about the diverse cosmetic products containing lipid nanoparticles, whether they are in clinical trials or already in the market.
In the first part, a brief introduction regarding the structure of the skin, the definition of cosmetic products, their main characteristics and applications are presented. In the second part are described the lipid nanoparticles systems, considering their structural characteristics, different applications in cosmetology and are given some examples of the cosmetic products that are already on the market
- …
