The pros and comms of gene sequencing

Full-gene sequencing undoubtedly comes with its pluses and its minuses. In this article, the authors aim to weigh up the pros and cons not only from the point of view of the patient but also in view of the doctor's possible perspective. Either party may be for or against it for a variety of reasons - for example, a fear of knowing too much on the part of the patient, and concerns about possible over-treatment on the part of the healthcare professional. One thing is certain: the possibility of full-gene sequencing is here and here to stay. At the very least, doctors need to make patients aware of their options, while offering balanced advice

Adam Smith and the Marquis de Condorcet. Did they really meet?

This article focuses on the alleged direct acquaintanceship between Condorcet and Adam Smith. Mistaken infor-mation about this issue was repeated many times in the literature of the late 1800s and 1900s. It is presumed that they met in France, during Smith’s journey there, chez Sophie de Grouchy. I will attempt to show that the meeting be-tween the two authors was not in fact arranged by Sophie de Grouchy, Condorcet’s wife, even though she was very interested in Smithian theories, especially about the category of “sympathy”, as confirmed by her French translation of the Theory of Moral Sentiments. My purpose is to demonstrate that Madame de Condorcet did never meet Smith and, as a result, she could not have introduced Condorcet to Smith. A greater degree of probability can be attributed to the version that indicates Turgot as the intermediary between Condorcet and Smith. In my opinion, not even this hypothesis is totally convincing, because neither Smith nor Condorcet ever talk about their meeting. Moreover, there is no evidence of correspondence between them.This article focuses on the alleged direct acquaintanceship between Condorcet and Adam Smith. Mistaken infor-mation about this issue was repeated many times in the literature of the late 1800s and 1900s. It is presumed that they met in France, during Smith’s journey there, chez Sophie de Grouchy. I will attempt to show that the meeting be-tween the two authors was not in fact arranged by Sophie de Grouchy, Condorcet’s wife, even though she was very interested in Smithian theories, especially about the category of “sympathy”, as confirmed by her French translation of the Theory of Moral Sentiments. My purpose is to demonstrate that Madame de Condorcet did never meet Smith and, as a result, she could not have introduced Condorcet to Smith. A greater degree of probability can be attributed to the version that indicates Turgot as the intermediary between Condorcet and Smith. In my opinion, not even this hypothesis is totally convincing, because neither Smith nor Condorcet ever talk about their meeting. Moreover, there is no evidence of correspondence between them

Clinical guidelines as plans: An ontological theory

Clinical guidelines are special types of plans realized by collective agents. We provide an ontological theory of such plans that is designed to support the construction of a framework in which guideline-based information systems can be employed in the management of workflow in health care organizations. The framework we propose allows us to represent in formal terms how clinical guidelines are realized through the actions of are realized through the actions of individuals organized into teams. We provide various levels of implementation representing different levels of conformity on the part of health care organizations. Implementations built in conformity with our framework are marked by two dimensions of flexibility that are designed to make them more likely to be accepted by health care professionals than standard guideline-based management systems. They do justice to the fact 1) that responsibilities within a health care organization are widely shared, and 2) that health care professionals may on different occasions be non-compliant with guidelines for a variety of well justified reasons. The advantage of the framework lies in its built-in flexibility, its sensitivity to clinical context, and its ability to use inference tools based on a robust ontology. One disadvantage lies in its complicated implementation

Epigenetic treatment of solid tumours. A review of clinical trials

Epigenetic treatment has been approved by regulatory agencies for haematological malignancies. The success observe in cutaneous lymphomas represents a proof of principle that similar results may be obtained in solid tumours. Several agents that interfere with DNA methylation-demethylation and histones acetylation/deacetylation have been studied, and some (such as azacytidine, decitabine, valproic acid and vorinostat) are already in clinical use. The aim of this review is to provide a brief overview of the molecular events underlying the antitumour effects of epigenetic treatments and to summarise data available on clinical trials that tested the use of epigenetic agents against solid tumours. We not only list results but also try to indicate how the proper evaluation of this treatment might result in a better selection of effective agents and in a more rapid development. We divided compounds in demethylating agents and HDAC inhibitors. For each class, we report the antitumour activity and the toxic side effects. When available, we describe plasma pharmacokinetics and pharmacodynamic evaluation in tumours and in surrogate tissues (generally white blood cells). Epigenetic treatment is a reality in haematological malignancies and deserves adequate attention in solid tumours. A careful consideration of available clinical data however is required for faster drug development and possibly to re-evaluate some molecules that were perhaps discarded too early

Risk of cancer after assisted reproduction: a review of the available evidences and guidance to fertility counselors

Infertile women requiring ovarian stimulation and assisted reproduction techniques (ART) are faced with difficult issues. The fear that using hormones could increase their risk of cancer is the most significant. One of the main challenges for assessing cancer risk after ART is the difficulty to separate it from the underlying condition of infertility per se. The delay or the inability to achieve a pregnancy is an important risk factor for breast, endometrial and ovarian cancer. We analyzed the current literature on the topic

A rare case of leiomyoma of the bladder

Bladder leiomyoma is a benign tumour of the bladder and constitute <0.5% of all bladder tumors. We report a clinical case of a 51‑year‑old female who presented with with symptomatic bladder leiomyoma. An ultrasound examination showed well-defined bladder leiomyoma in the right posterior bladder wall, which was excised through a transurethral resection. The pathologic diagnosis was bladder leiomyoma

Open and / or laparoscopic surgical treatment of liver hydatic cysts

Hydatid disease is a severe parasitic disease with a widely ranging distribution. In the human being the liver is the most frequent organ affected. 1 The treatment should be individualized to the morphology, size, number and location of the cysts, that is why a variety of surgical operations have been advocated from complete resection like total pericystectomy or partial hepatectomy to laparoscopy to a minimally invasive procedures like percutaneous aspiration of cysts to conservative drug therapy. 3-4 This study compares laparoscopic versus open management of the hydatid cyst of liver the surgical approach to liver echinococcosis is still a controversial issue and shows our results of surgical treatment of liver hydatid cysts during a 3-years period

La Telecardiologia

Telemedicine is a form of real-time sharing of patient information, so that the contribution of more health workers at the same time can ensure a higher level of care, reducing hospitalization costs and transport . This work is the fruit of a "handful" of traders, who for some time dealing with this issue and are often made promoters of cultural and scientific experiences to sensitize decision makers to bring up a new Health how to manage the patient...

TFAP2E-DKK4 and Chemoresistance in Colorectal Cancer

[No abstract available