Phase separation of binary fluids with dynamic temperature

Phase separation of binary fluids quenched by contact with cold external walls is considered. Navier-Stokes, convection-diffusion, and energy equations are solved by lattice Boltzmann method coupled with finite-difference schemes. At high viscosity, different morphologies are observed by varying the thermal diffusivity. In the range of thermal diffusivities with domains growing parallel to the walls, temperature and phase separation fronts propagate towards the inner of the system with power-law behavior. At low viscosity hydrodynamics favors rounded shapes, and complex patterns with different lengthscales appear. Off-symmetrical systems behave similarly but with more ordered configurations.Comment: Accepted for publication in Phys. Rev. E, 11 figures, best quality figures available on reques

Professione designer, basterà una norma tecnica per riconoscerla?

Il sistema normativo italiano per svolgere la professione del designer. Lo stato dell'arte sul riconoscimento della professione

Enhancing operational performance of AHUs through an advanced fault detection and diagnosis process based on temporal association and decision rules

The pervasive monitoring of HVAC systems through Building Energy Management Systems (BEMSs) is enabling the full exploitation of data-driven based methodologies for performing advanced energy management strategies. In this context, the implementation of Automated Fault Detection and Diagnosis (AFDD) based on collected operational data of Air Handling Units (AHUs) proved to be particularly effective to prevent anomalous running modes which can lead to significant energy waste over time and discomfort conditions in the built environment. The present work proposes a novel methodology for performing AFDD, based on both unsupervised and supervised data-driven methods tailored according to the operation of an AHU during transient and non-transient periods. The whole process is developed and tested on a sample of real data gathered from monitoring campaigns on two identical AHUs in the framework of the Research Project ASHRAE RP-1312. During the start-up period of operation, the methodology exploits Temporal Association Rules Mining (TARM) algorithm for an early detection of faults, while during non-transient period a number of classification models are developed for the identification of the deviation from the normal operation. The proposed methodology, conceived for quasi real-time implementation, proved to be capable of robustly and promptly identifying the presence of typical faults in AHUs

Online implementation of a soft actor-critic agent to enhance indoor temperature control and energy efficiency in buildings

Recently, a growing interest has been observed in HVAC control systems based on Artificial Intelligence, to improve comfort conditions while avoiding unnecessary energy consumption. In this work, a model-free algorithm belonging to the Deep Reinforcement Learning (DRL) class, Soft Actor-Critic, was implemented to control the supply water temperature to radiant terminal units of a heating system serving an office building. The controller was trained online, and a preliminary sensitivity analysis on hyperparameters was performed to assess their influence on the agent performance. The DRL agent with the best performance was compared to a rule-based controller assumed as a baseline during a three-month heating season. The DRL controller outperformed the baseline after two weeks of deployment, with an overall performance improvement related to control of indoor temperature conditions. Moreover, the adaptability of the DRL agent was tested for various control scenarios, simulating changes of external weather conditions, indoor temperature setpoint, building envelope features and occupancy patterns. The agent dynamically deployed, despite a slight increase in energy consumption, led to an improvement of indoor temperature control, reducing the cumulative sum of temperature violations on average for all scenarios by 75% and 48% compared to the baseline and statically deployed agent respectively

Heat waves and adaptation strategies in a Mediterranean urban context

Heat waves can be considered as an emerging challenge among the potential health risks generated by urbanization and climate changes. Heat waves are becoming more frequent, long and intense, and can be defined as meteorological extreme events consisting in prolonged time of extremely high temperatures in a particular region. The following paper addresses health threats due to heat waves presenting the case study of Lecce, a city located in Southern Italy; the Mediterranean area is already recognized in international literature as a hot-spot for climate changes. This work assesses the potential impact of two different adaptation strategies. Methods: We have tested the effectiveness of cool surfaces and urban forestry as adaptation approaches to cope with heat waves. The microclimate computer-based model “ENVI-met” was adopted to predict thermal scenarios arising from the two proposed interventions. The parameters analysed consisted in temperature and relative humidity. Results: Urban forestry approach seem to lower temperature (that represents the major cause of urban overheating) better than cool surfaces strategy, but relative humidity produced by the evapotranspiration processes of urban forestry has also negative influences on temperature perceived by pedestrians (thermal discomfort). Conclusion: Vegetation represents both an adaptation and a mitigation strategy to climate changes that guarantees an improvement of air quality, with consequent psychological and physical benefits. Wide campaigns aimed at planting trees and increasing the urban green coverage should be systematically planned and fostered by national, regional and local institutions preferably with the involvement of research departments, schools and citizens’ associations

Superhydrophobic coatings as anti-icing systems for small aircraft

Traditional anti-icing/de-icing systems, i.e., thermal and pneumatic, in most cases require a power consumption not always allowable in small aircraft. Therefore, the use of passive systems, able to delay the ice formation, or reduce the ice adhesion strength once formed, with no additional energy consumption, can be considered as the most promising solution to solve the problem of the ice formation, most of all, for small aircraft. In some cases, the combination of a traditional icing protection system (electrical, pneumatic, and thermal) and the passive coatings can be considered as a strategic instrument to reduce the energy consumption. The effort of the present work was to develop a superhydrophobic coating, able to reduce the surface free energy (SFE) and the work of adhesion (WA) of substrates, by a simplified and non-expensive method. The developed coating, applied as a common paint with an aerograph, is able to reduce the SFE of substrates by 99% and the WA by 94%. The effects of both chemistry and surface morphology on the wettability of surfaces were also studied. In the reference samples, the higher the roughness, the lower the SFE and the WA. In coated samples with roughness ranging from 0.4 and 3 μm no relevant variations in water contact angle, nor in SFE andWA were observed

The role of miRNA-133b and its target gene SIRT1 in FAP-derived desmoid tumor.

Signaling pathways have a key role in driving the uncontrolled development of familial adenomatous polyposis (FAP)- associated and sporadic desmoid tumors (DTs). The relationship between the Wnt/b-catenin signaling pathway and DTs has been extensively studied, but no reliable biomarkers able to detect their histological subtype have been identified for the accurate diagnosis. In this study we studied the differences in miRNA expression between sporadic (20 patients) and FAP-associated DTs (7 patients) using microarray confirmed by quantitative PCR (qPCR). The analysis showed 19 dysregulated miRNAs. Among them miR-133b levels were significantly lower in FAP-associated DT than in sporadic DT. Therefore, two mRNAs, associated to miR-133b and β-catenin expression, the SIRT1 and ELAVL1were analyzed. The qPCR analysis showed that SIRT1 mRNA levels were significantly up-regulated in FAP-associated DT than in sporadic DT, whereas no differences in ELAVL1 expression was observed between these two DT types. In addition, a negative correlation was observed between miR-133b and SIRT1 in FAP-associated DTs, but not in sporadic DTs. The miR-133b-SIRT1-β-catenin axis may represent a novel mechanism underlying progression of FAP-associated D

The role of interfacial lipids in stabilizing membrane protein oligomers

Oligomerization of membrane proteins in response to lipid binding has a critical role in many cell-signalling pathways1 but is often difficult to define2 or predict3. Here we report the development of a mass spectrometry platform to determine simultaneously the presence of interfacial lipids and oligomeric stability and to uncover how lipids act as key regulators of membrane-protein association. Evaluation of oligomeric strength for a dataset of 125 α-helical oligomeric membrane proteins reveals an absence of interfacial lipids in the mass spectra of 12 membrane proteins with high oligomeric stability. For the bacterial homologue of the eukaryotic biogenic transporters (LeuT4, one of the proteins with the lowest oligomeric stability), we found a precise cohort of lipids within the dimer interface. Delipidation, mutation of lipid-binding sites or expression in cardiolipin-deficient Escherichia coli abrogated dimer formation. Molecular dynamics simulation revealed that cardiolipin acts as a bidentate ligand, bridging across subunits. Subsequently, we show that for the Vibrio splendidus sugar transporter SemiSWEET5, another protein with low oligomeric stability, cardiolipin shifts the equilibrium from monomer to functional dimer. We hypothesized that lipids are essential for dimerization of the Na+/H+ antiporter NhaA from E. coli, which has the lowest oligomeric strength, but not for the substantially more stable homologous Thermus thermophilus protein NapA. We found that lipid binding is obligatory for dimerization of NhaA, whereas NapA has adapted to form an interface that is stable without lipids. Overall, by correlating interfacial strength with the presence of interfacial lipids, we provide a rationale for understanding the role of lipids in both transient and stable interactions within a range of α-helical membrane proteins, including G-protein-coupled receptors

The correlation between low back pain and strength training in elite athletes: a literature review

This study aims to analyze the correlation between LBP and elite athletes who practice sports where strength training intervenes via weightlifting. To analyse the correlation between low back pain and athletes who practice sports where strength training programs, a narrative review was conducted by two independent author through MEDLINE database search. Inclued study’s methodology quality has been evaluated using NIH quality assessment tool for Observational Cohort and Cross-Sectional Studies. Out of 830 retrieved articles, after titles, abstracts and full text assessment, four studies met the inclusion criteria and were included in the present narrative review. The NIH total score ranged from 10 to 12 points. Demographic and sport-specific factors can influence the prevalence of LBP. Our findings highlight the importance of developing future research to provide prevention programs to reduce the incidence of LBP, taking into account the demographics of athletes and the unique nature of their sport activity