Assessing partnership alternatives in an IT network employing analytical methods

One of the main critical success factors for the companies is their ability to build and maintain an effective collaborative network. This is more critical in the IT industry where the development of sustainable competitive advantage requires an integration of various resources, platforms, and capabilities provided by various actors. Employing such a collaborative network will dramatically change the operations management and promote flexibility and agility. Despite its importance, there is a lack of an analytical tool on collaborative network building process. In this paper, we propose an optimization model employing AHP and multiobjective programming for collaborative network building process based on two interorganizational relationships’ theories, namely, (i) transaction cost theory and (ii) resource-based view, which are representative of short-term and long-term considerations. The five different methods were employed to solve the formulation and their performances were compared. The model is implemented in an IT company who was in process of developing a large-scale enterprise resource planning (ERP) system. The results show that the collaborative network formed through this selection process was more efficient in terms of cost, time, and development speed. The framework offers novel theoretical underpinning and analytical solutions and can be used as an effective tool in selecting network alternatives

A robust fuzzy possibilistic AHP approach for partner selection in international strategic alliance

The international strategic alliance is an inevitable solution for making competitive advantage and reducing the risk in today’s business environment. Partner selection is an important part in success of partnerships, and meanwhile it is a complicated decision because of various dimensions of the problem and inherent conflicts of stockholders. The purpose of this paper is to provide a practical approach to the problem of partner selection in international strategic alliances, which fulfills the gap between theories of inter-organizational relationships and quantitative models. Thus, a novel Robust Fuzzy Possibilistic AHP approach is proposed for combining the benefits of two complementary theories of inter-organizational relationships named, (1) Resource-based view, and (2) Transaction-cost theory and considering Fit theory as the perquisite of alliance success. The Robust Fuzzy Possibilistic AHP approach is a noveldevelopment of Interval-AHP technique employing robust formulation; aimed at handling the ambiguity of the problem and let the use of intervals as pairwise judgments. The proposed approach was compared with existing approaches, and the results show that it provides the best quality solutions in terms of minimum error degree. Moreover, the framework implemented in a case study and its applicability were discussed

Developing lean and responsive supply chains : a robust model for alternative risk mitigation strategies in supply chain designs

This paper investigates how organization should design their supply chains (SCs) and use risk mitigation strategies to meet different performance objectives. To do this, we develop two mixed integer nonlinear (MINL) lean and responsive models for a four-tier SC to understand these four strategies: i) holding back-up emergency stocks at the DCs, ii) holding back-up emergency stock for transshipment to all DCs at a strategic DC (for risk pooling in the SC), iii) reserving excess capacity in the facilities, and iv) using other facilities in the SC’s network to back-up the primary facilities. A new method for designing the network is developed which works based on the definition of path to cover all possible disturbances. To solve the two proposed MINL models, a linear regression approximation is suggested to linearize the models; this technique works based on a piecewise linear transformation. The efficiency of the solution technique is tested for two prevalent distribution functions. We then explore how these models operate using empirical data from an automotive SC. This enables us to develop a more comprehensive risk mitigation framework than previous studies and show how it can be used to determine the optimal SC design and risk mitigation strategies given the uncertainties faced by practitioners and the performance objectives they wish to meet

Achieving sustainable development of supply chain by incorporating various carbon regulatory mechanisms

Nowadays, sustainability issues have received considerable attention in supply chain management because of the governmental requirements as well as expectations of the people. This paper introduces a novel supply chain network design problem to cover three dimensions of sustainability, namely economic, environmental, and social. The advantage of the presented model stems from considering the booming development aligned with reduction in environmental impact. In this paper, to achieve the mentioned benefits and to derive a more sustainable supply chain, a novel model in the presence of the most commonly used carbon policies is proposed. This paper, addresses sustainable development through imposing proper carbon regulatory mechanisms. Main contribution of this study is to consider the effect of imposing carbon policies on environmental advantages as well as improving the regional development level in a supply chain network design problem. Moreover, the shipment consolidation decisions are utilized to reduce cost as well as environmental impact. In addition, a novel mixed uncertainty approach is proposed to capture the uncertain emission parameters. The numerical examples and a case study are analyzed to evaluate the performance of the proposed models. It is concluded that, a high-growth economy with low-carbon can be made and also almost global well-being of people is ensured by applying the proposed model. Some managerial insights are provided for the enterprises of supply chains to make the most appropriate sustainable decisions. Finally, proper carbon emission policies are suggested based on the region sustainability characteristics

Considering pricing and uncertainty in designing a reverse logistics network

Companies try to maximize their profits by recovering returned products of highly uncertain quality and quantity. In this paper, a reverse logistics network for an Original Equipment Manufacturer (OEM) is presented. Returned products are selected for remanufacturing or scrapping, based on their quality and proportional prices are offered to customers. A Mixed Integer Non-linear Programming (MINLP) model is proposed to determine the location of collection centers, the optimum price of returned products and the sorting policy. The risk in the objective function is measured using the Conditional Value at Risk (CVaR) metric. CVaR measures the risk of an investment in a conservative way by considering the maximum lost. The results are analyzed for various values of the risk parameters ({\alpha}, and {\lambda}). These parameters indicate that considering risk affects prices, the classification of returned products, the location of collection centers and, consequently, the objective function. The model performs more conservatively when the weight of the CVaR part ({\lambda}) and the value of the confidence level {\alpha} are increased. The results show that better profits are obtained when we take CVaR into account

Supply chain network design considering sustainable development paradigm:A case study in cable industry

The concern about environmental and social impacts of business activities has led to introducing a new paradigm called, sustainable development. It can help to build a low-carbon high-growth global economy and guarantee the global well-being of people. In this paper, three pillars of sustainable development, i.e., economic, environmental, and social, are considered and discussed to design a supply chain network. The proposed model tries to maximize profit primarily while capturing societal community development by prioritizing the less developed regions. Moreover, the model ensures that the environmentally friendly facilities can operate in the supply chain network while others have to be repaired. Furthermore, quantifying the benefits of transportation decisions in terms of both cost and environmental impact savings to improve the sustainability of logistics systems is considered. In addition, the model is regarded as robust programming for the problem to approximate real situations. The proposed model is implemented in some numerical examples and in a real case study. Numerical results and computational analysis are indicative of the significance of the model and through conducting the case study, it is demonstrated that the proposed model can be implemented successfully in practice and it would be beneficial to all the three pillars of sustainable development. Moreover, the managerial insights for the managers of the supply chain networks are provided to make the most appropriate decisions

Social sustainability of treatment technologies for bioenergy generation from the municipal solid waste using best worst method

Despite the fundamental role of the social aspect in the implementation of sustainability in the bio-based industries, most of the sustainability assessments research have addressed the environmental and economic dimensions. However, the social dimension has been neglected and it can cause an irreparable outcome in the biotechnology industries. Following this issue, this study propounds a modified systemic approach for a social sustainability impact assessment of the treatment technologies for converting waste into bioenergy, based on a review on the common social assessment methods. As it is known, the guideline presented by the United Nations Environment Program (UNEP) and the Society of Environmental Toxicology and Chemistry (2009) due to considering social life cycle assessment has a comprehensive look at the stakeholders. Therefore, in this paper, UNEP method was selected. However, it needs to be modified based on the bio-energy supply chain derived from municipal solid waste. For this purpose, the bioenergy value chain derived from municipal solid waste was designed and combined with UNEP guideline, to complete the level of stakeholder subgroups and the levels of the indicators. The final method of the social assessment system was presented to the board of experts and finalized. In order to design the measurement part of the social assessment system, because of a multi criteria decision making nature of the social sustainability evaluation of the conversion technologies of municipal solid waste to bio-energies, a recent developed multi-criteria decision making method so-called Best Worst Method (BWM) was used in two stages. The criteria are ranked according to their average weight obtained through Best Worst method. One of the major novelties in this research is the way of application of the best worst technique in the second stage. The model was implemented in the case of Tehran as one of the pioneering Iranian municipalities with high potential to produce bioenergy. The results of this study help decision makers to decide where to concentrate their attention during the implementation stage, and to increase social sustainability in their bioenergy supply chains derived waste.</p

Tyrosine Phosphorylation of Eps15 Is Required for Ligand-Regulated, but Not Constitutive, Endocytosis

Membrane receptors are internalized either constitutively or upon ligand engagement. Whereas there is evidence for differential regulation of the two processes, little is known about the molecular machinery involved. Previous studies have shown that an unidentified kinase substrate is required for endocytosis of the epidermal growth factor receptor (EGFR), the prototypical ligand-inducible receptor, but not of the transferrin receptor (TfR), the prototypical constitutively internalized receptor. Eps15, an endocytic protein that is tyrosine phosphorylated by EGFR, is a candidate for such a function. Here, we show that tyrosine phosphorylation of Eps15 is necessary for internalization of the EGFR, but not of the TfR. We mapped Tyr 850 as the major in vivo tyrosine phosphorylation site of Eps15. A phosphorylation-negative mutant of Eps15 acted as a dominant negative on the internalization of the EGFR, but not of the TfR. A phosphopeptide, corresponding to the phosphorylated sequence of Eps15, inhibited EGFR endocytosis, suggesting that phosphotyrosine in Eps15 serves as a docking site for a phosphotyrosine binding protein. Thus, tyrosine phosphorylation of Eps15 represents the first molecular determinant, other than those contained in the receptors themselves, which is involved in the differential regulation of constitutive vs. regulated endocytosis