Metabolic Super Scan in 18F-FDG PET/CT Imaging

A 50-yr-old man presented with intermittent hemoptysis and was diagnosed small cell lung cancer. 18F-FDG PET/CT for staging demonstrated extensive hypermetabolic lesions throughout the skeleton and liver. Interestingly, skeletal muscles of limbs, mediastinum, bowel, and especially brain showed very low FDG uptake. Because of some characteristics in common with super scan on skeletal scintigraphy, this case could be considered as 'metabolic super scan'

Navigating Social and Emotional Learning from the Inside Out: ?????????????????????Looking Inside and Across 33 leading SEL Programs: A Practical Resource for Schools and OST Providers

The field of social and emotional learning (SEL) is rapidly expanding, as educators bring a sharper focus to helping children build skills beyond academic knowledge. School climate initiatives, anti-bullying work, positive behavior supports and other SEL efforts are now steering programs in schools and out-of-school-time (OST) settings across the country. Building children's SEL skills has taken on even more urgency in the wake of the COVID-19 pandemic.This updated and expanded guide to evidence-based SEL programs offers detailed information on 33 pre-K through elementary school programs, encompassing curricular content and program highlights. Practitioners from schools, early childhood education (ECE) providers and out-of-school time (OST) can use this resource to look "inside and across" programs to better understand program content and assess program fit with their district or community needs.New chapters in the 2021 edition include recommendations for achieving equitable SEL (including common barriers and best practices) and guidance on trauma-informed or trauma-sensitive approaches to SEL, which includes principles, practices and recommendations for integrating SEL into regular practice

PET/CT without capacity limitations: a Danish experience from a European perspective

# The Author(s) 2011. This article is published with open access at Springerlink.com Objectives We report the 3-year clinical experience of a large new Danish PET/CT centre without capacity limitations in relation to national and European developments. Methods The use of PET/CT in cancer was registered from early 2006 to early 2009 to judge the impact on patient management and to compare it with national and European trends. Results 6056 PET/CT examinations were performed in 4327 patients. Activity increased by 86 examinations per month compared with the same month the year before. Referrals came primarily from oncology (23.0%), haematology (21.6%), surgery (12.6%), internal medicine (12.7%) and gynaecology (5.5%). Referral indications were diagnosis (31.3%), staging (22.3%), recurrence detection (21.2%), response evaluation (17.0%) and other (8.2%). Response from nearly 60 % of users showed that PET/CT caused a change in diagnosis and/or staging and/or treatment plan in 36.0 % of cases. During the study period, there was a steep increase in the national use of FDG and in the European use of PET/CT. Conclusions We recorded a constantly increasing use of PET/CT that caused a change in diagnosis and/or stagin

Molecular imaging in oncology: the acceptance of PET/CT and the emergence of MR/PET imaging

In the last decade, PET-only systems have been phased out and replaced with PET-CT systems. This merger of a functional and anatomical imaging modality turned out to be extremely useful in clinical practice. Currently, PET-CT is a major diagnostic tool in oncology. At the dawn of the merger of MRI and PET, another breakthrough in clinical imaging is expected. The combination of these imaging modalities is challenging, but has particular features such as imaging biological processes at the same time in specific body locations

Studies on intronless mRNA nucleocytoplasmic export elements

Splicing is coupled to and essential for the efficient nucleocytoplasmic transport of messages from intron-containing genes; however, naturally intronless messages are efficiently transported to the cytoplasm without being spliced. We are using naturally intronless genes to study the mechanism governing nucleocytoplasmic transport of unspliced messages. Previous work from the Carmichael laboratory reported that the mouse histone H2a gene contains a small element that can enhance the cytoplasmic accumulation of unspliced RNAs (Huang and Carmichael, 1997). Here we report an element within the mouse histone H3.2 coding region likewise enhances nucleocytoplasmic export of intronless beta-globin cDNA transcripts. The most active sequence is 132 nucleotides in length. This element both enhances polyadenylation, as well as cytoplasmic accumulation, of intronless beta-globin cDNA transcripts. The sequence has been further narrowed to a 22 nt element that has the same positive effects on nucleocytoplasmic export and polyadenylation as the 132 nt element. Experimental evidence suggests that binding of SR proteins correlates with export activity. These and other results support the hypothesis that SR proteins are important components of the nucleocytoplasmic mRNA transport machinery (Huang and Steitz, 2001). ^ Additional work studying the other naturally intronless genes including somatostatin transmembrane receptor 5 (SSTR5) were utilized to look at the general mechanism governing nucleocytoplasmic transport of mRNA. Here we report the identification of two RNA export elements, of ∼270 nt from SSTR5, that enhance polyadenylation and nucleocytoplasmic export of intronless beta-globin cDNA transcripts. Experimental data suggest that SR proteins most likely play a role in the activity of the second SSTR5 element, while the first element\u27s binding partners remain unclear. Similar elements could not be identified in α-interferon and Hsp70. ^ Recently it has been reported that the phosphorylation state of SR proteins may affect export of associated mRNA (Huang et al., 2004). We report here the identification of a small nuclear protein that could potentially be a phosphatase inhibitor. The protein was first noted in a co-immunoprecipitation with αSR antibody. Mass spectrometry identified one peptide, DAVEDLESVGK, that appears in two different overlapping genes, dermcidin, and the predicted protein, protein phosphatase inhibitor-1.