New Approaches to the Treatment of Age-Related Brain Disorders

Two novel reversible enzyme inhibitors involved in monoamine metabolism are described. The novel and reversible inhibitors are the catechol-O-methyl-transferase (COMT) inhibitor, Ro 40-7592 (3,4-dihydroxy-4'-methyl-5-nitrobenzophenone), and the monoamine oxidase type-B (MAO-B) inhibitor, Ro 19-6327 (N-(2-aminoethyl)-5-chloro-2-pyridine carboxamide HC1). These may be of special therapeutic benefit in Parkinson's and Alzheimer's disease

Single stars in the Hyades open cluster. Fiducial sequence for testing stellar and atmospheric models

Age and mass determinations for isolated stellar objects remain model-dependent. While stellar interior and atmospheric theoretical models are rapidly evolving, we need a powerful tool to test them. Open clusters are good candidates for this role. We complement previous studies on the Hyades multiplicity by Lucky Imaging observations with the AstraLux Norte camera. This allows us to exclude possible binary and multiple systems with companions outside 2--7 AU separation and to create a "single-star sequence" for the Hyades. The sequence encompasses 250 main-sequence stars ranging from A5V to M6V. Using the "Tool for Astrophysical Data Analysis" (TA-DA), we create various theoretical isochrones applying different combinations of interior and atmospheric models. We compare the isochrones with the observed Hyades single-star sequence on J vs. J - K_s, J vs. J - H and K_s vs. H - K_s color-magnitude diagrams. As a reference we also compute absolute fluxes and magnitudes for all stars from X-ray to mid-infrared based on photometric measurements available in the literature(ROSAT X-ray, GALEX UV, APASS gri, 2MASS JHK_s, and WISE W1 to W).We find that combinations of both PISA and DARTMOUTH stellar interior models with BT-Settl 2010 atmospheric models describe the observed sequence well. The full sequence covers the mass range 0.13 to 2.3 Msun, and effective temperatures between 3060 K and 8200 K. Within the measurement uncertainties, the current generation of models agree well with the single-star sequence. The primary limitations are the uncertainties in the measurement of the distance to individual Hyades members, and uncertainties in the photometry. Additionally, a small (~0.05 mag) systematic offset can be noted on J vs. J - K and K vs. H - K diagrams - the observed sequence is shifted to redder colors from the theoretical predictions.Comment: 6 pages, 2 figures, 1 table. The extended version of the table will be available online soon. Accepted for publication in Astronomy & Astrophysic

Ameliorating Systematic Uncertainties in the Angular Clustering of Galaxies: A Study using SDSS-III

We investigate the effects of potential sources of systematic error on the angular and photometric redshift, z_phot, distributions of a sample of redshift 0.4 < z < 0.7 massive galaxies whose selection matches that of the Baryon Oscillation Spectroscopic Survey (BOSS) constant mass sample. Utilizing over 112,778 BOSS spectra as a training sample, we produce a photometric redshift catalog for the galaxies in the SDSS DR8 imaging area that, after masking, covers nearly one quarter of the sky (9,913 square degrees). We investigate fluctuations in the number density of objects in this sample as a function of Galactic extinction, seeing, stellar density, sky background, airmass, photometric offset, and North/South Galactic hemisphere. We find that the presence of stars of comparable magnitudes to our galaxies (which are not traditionally masked) effectively remove area. Failing to correct for such stars can produce systematic errors on the measured angular auto-correlation function, w, that are larger than its statistical uncertainty. We describe how one can effectively mask for the presence of the stars, without removing any galaxies from the sample, and minimize the systematic error. Additionally, we apply two separate methods that can be used to correct the systematic errors imparted by any parameter that can be turned into a map on the sky. We find that failing to properly account for varying sky background introduces a systematic error on w. We measure w, in four z_phot slices of width 0.05 between 0.45 < z_phot < 0.65 and find that the measurements, after correcting for the systematic effects of stars and sky background, are generally consistent with a generic LambdaCDM model, at scales up to 60 degrees. At scales greater than 3 degrees and z_phot > 0.5, the magnitude of the corrections we apply are greater than the statistical uncertainty in w.Comment: Accepted by MNRA

High-order 3D Voronoi tessellation for identifying Isolated galaxies, Pairs and Triplets

Geometric method based on the high-order 3D Voronoi tessellation is proposed for identifying the single galaxies, pairs and triplets. This approach allows to select small galaxy groups and isolated galaxies in different environment and find the isolated systems. The volume-limited sample of galaxies from the SDSS DR5 spectroscopic survey was used. We conclude that in such small groups as pairs and triplets the segregation by luminosity is clearly observed: galaxies in the isolated pairs and triplets are on average two times more luminous than isolated galaxies. We consider the dark matter content in different systems. The median values of mass-to-luminosity ratio are 12 M_sol/L_sol for the isolated pairs and 44 M_sol/L_sol for the isolated triplets; 7 (8) M_sol/L_sol for the most compact pairs (triplets). We found also that systems in the denser environment have greater rms velocity and mass-to-luminosity ratio.Comment: 11 pages, 7 figures, Accepted 2008 October 25 in MNRA

Modelling non-linear redshift-space distortions in the galaxy clustering pattern: systematic errors on the growth rate parameter

We investigate the ability of state-of-the-art redshift-space distortions models for the galaxy anisotropic two-point correlation function \xi(r_p, \pi), to recover precise and unbiased estimates of the linear growth rate of structure f, when applied to catalogues of galaxies characterised by a realistic bias relation. To this aim, we make use of a set of simulated catalogues at z = 0.1 and z = 1 with different luminosity thresholds, obtained by populating dark-matter haloes from a large N-body simulation using halo occupation prescriptions. We examine the most recent developments in redshift-space distortions modelling, which account for non-linearities on both small and intermediate scales produced respectively by randomised motions in virialised structures and non-linear coupling between the density and velocity fields. We consider the possibility of including the linear component of galaxy bias as a free parameter and directly estimate the growth rate of structure f. Results are compared to those obtained using the standard dispersion model, over different ranges of scales.We find that the model of Taruya et al. (2010), the most sophisticated one considered in this analysis, provides in general the most unbiased estimates of the growth rate of structure, with systematic errors within 4% over a wide range of galaxy populations spanning luminosities between L > L* and L > 3L*. The scale-dependence of galaxy bias plays a role on recovering unbiased estimates of f when fitting quasi non-linear scales. Its effect is particularly severe for most luminous galaxies, for which systematic effects in the modelling might be more difficult to mitigate and have to be further investigated. [...]Comment: 17 pages, 16 figures, Accepted for publication in MNRA

The MUSIC of Galaxy Clusters I: Baryon properties and Scaling Relations of the thermal Sunyaev-Zel'dovich Effect

We introduce the Marenostrum-MultiDark SImulations of galaxy Clusters (MUSIC) Dataset, one of the largest sample of hydrodynamically simulated galaxy clusters with more than 500 clusters and 2000 groups. The objects have been selected from two large N-body simulations and have been resimulated at high resolution using SPH together with relevant physical processes (cooling, UV photoionization, star formation and different feedback processes). We focus on the analysis of the baryon content (gas and star) of clusters in the MUSIC dataset both as a function of aperture radius and redshift. The results from our simulations are compared with the most recent observational estimates of the gas fraction in galaxy clusters at different overdensity radii. When the effects of cooling and stellar feedbacks are included, the MUSIC clusters show a good agreement with the most recent observed gas fractions quoted in the literature. A clear dependence of the gas fractions with the total cluster mass is also evident. The impact of the aperture radius choice, when comparing integrated quantities at different redshifts, is tested: the standard definition of radius at a fixed overdensity with respect to critical density is compared with a definition based on the redshift dependent overdensity with respect to background density. We also present a detailed analysis of the scaling relations of the thermal SZ (Sunyaev Zel'dovich) Effect derived from MUSIC clusters. The integrated SZ brightness, Y, is related to the cluster total mass, M, as well as, the M-Y counterpart, more suitable for observational applications. Both laws are consistent with predictions from the self-similar model, showing a very low scatter. The effects of the gas fraction on the Y-M scaling and the presence of a possible redshift dependence on the Y-M scaling relation are also explored.Comment: 22 pages, 25 figures, accepted for pubblication by MNRA

Photometric determination of the mass accretion rates of pre-main sequence stars. II. NGC346 in the Small Magellanic Cloud

[Abridged] We have studied the properties of the stellar populations in the field of the NGC346 cluster in the Small Magellanic Cloud, using a novel self-consistent method that allows us to reliably identify pre-main sequence (PMS) objects actively undergoing mass accretion, regardless of their age. The method does not require spectroscopy and combines broad-band V and I photometry with narrow-band Halpha imaging to identify all stars with excess Halpha emission and derive the accretion luminosity Lacc and mass accretion rate Macc for all of them. The application of this method to existing HST/ACS photometry of the NGC346 field has allowed us to identify and study 680 bona-fide PMS stars with masses from ~0.4 to ~4 Msolar and ages in the range from ~1 to ~30 Myr. This is the first study to reveal that, besides a young population of PMS stars (~ 1 Myr old), in this field there is also an older population of PMS objects with a median age of ~20 Myr. We provide for all of them accurate physical parameters. We study the evolution of the mass accretion rate as a function of stellar parameters and find that logMacc ~ -0.6 Log t + Log m + c, where t is the age of the star, m its mass and c a quantity that is higher at lower metallicity. The high mass accretion rates that we find suggest that a considerable fraction of the stellar mass is accreted during the PMS phase and that PMS evolutionary models that do not account for this effect will systematically underestimate the true age when compared with the observations.Comment: Accepted for publication in the ApJ. 14 pages, 11 figures. Corrected typos and reference