Heart’s secret encounter-extra skeletal Ewings sarcoma with cardiac involvement in adult: a case report

Ewing sarcoma is a rare, aggressive malignant tumour predominantly arising from bone or soft tissue in adolescents and young adults. Primary cardiac involvement is exceedingly uncommon, usually occurring as a result of metastatic spread. Here, we present a case of 22-year-old male with an atypical primary cardiac presentation of Ewings sarcoma, posing significant diagnostic challenges. A detailed evaluation revealed disseminated malignancy, including cardiac and systemic involvement. This report underscores the importance of rare malignancies in atypical cardiac presentations and highlights the value of a multidisciplinary approach in diagnosis and treatment.  

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Post-menopausal Sertoli-Leydig cell tumour: a report of two cases

Ovarian Sertoli-Leydig cell tumors (SLCTs) represent less than 0.2 percent of all ovarian cancers and are an uncommon type of sex cord–stromal malignancy. Since these tumors are discovered in young women at an early stage, the management challenge is in striking the correct balance between a treatment that is effective enough to stop recurrences but yet permits fertility preservation. We present 2 case report of patients, one presented with hirsuitism and on evaluation found to have elevated levels of serum total testosterone and suspicion of SLCTs in magnetic resonance imaging (MRI) pelvis. Total laparoscopic hysterectomy (TLH) was done with bilateral salpingo-oophorectomy (BSO) and histopathology report came as ovarian Leydig cell tumour. Second case with postmenopausal bleeding and on evaluation MRI report showed right ovarian solid tumour-fibroma/fibrothecoma. Tumour markers were normal. TLH was done with BSO, histopathology report came as ovarian SLCT

Atypical polypoid adenomyoma: insights into recurrence, malignant transformation and management: a case report

Atypical polypoid adenomyoma (APAM) is a rare, benign mixed epithelial-mesenchymal tumor of the uterus. It is characterized by its polypoid growth pattern and atypical histological features. This study aims to consolidate current knowledge regarding its clinical presentation, diagnostic criteria, treatment options, and potential for malignancy. There is a significant rate of recurrence associated with this tumor. It consists of unusual endometrial glands interspersed with bundles of smooth muscle fibers. It is frequently diagnosed in young women and may coexist with or progress to atypical endometrial hyperplasia or endometrioid endometrial carcinoma. We report a case of a 35-year-old woman affected by APAM treated with hysteroscopic resection. Given the risk of recurrence and progression, APAM might be treated via hysterectomy in patients with no desire for pregnancy

A rare case of endometriosis to clear cell ovarian carcinoma: a case report

Clear cell carcinoma of ovary is a rare tumour with a very low incidence in pregnancy. It is attributed to develop from an existing background of endometriosis. There are very few case reports of the above combination tumours in pregnancy. It is a very aggressive tumour with a worse prognosis and low survival rate because of its peculiar chemo resistant nature. Early detection and effective treatment are the best approach. The treatment options for advanced stages are still under research

Life cycle analysis of environmental impacts of earthen materials in the Portuguese context: Rammed earth and compressed earth blocks

In the Portuguese context, the life cycle assessment of building materials is still in its infancy. So far, there is only a small number of Environmental Product Declarations (EPDs) available, all target for industrially based materials. Although vernacular earthen materials are seen as ecological materials, with low potential environmental impacts, there are no studies that allow to quantitatively compare these materials with conventional ones, according to the applicable standards. In the case of Portugal, there are no EPDs or studies for these materials and the studies available worldwide are hard to compare, since they not follow the same life-cycle assessment methodology. This paper aims at contributing to a better understanding about the environmental performance of earthen materials by presenting results from the life cycle assessment of Compressed Earth Blocks (CEBs) and Rammed earth, based on specific life cycle inventory values obtained from a producer company, following the guidance provided by the standard EN15804. Among other conclusions, results show that CEB and Rammed earth have a total Embodied Energy of 3.94 MJ/block and 596 MJ/1m3 and a Global Warming Potential of 0.39 kg CO2 eq/block and 47.5 kg CO2 eq./1m3, respectively. In a cradle-to-gate analysis of different walls, the use of earthen building elements can result in reducing the potential environmental impacts in about 50%, when compared to the use of conventional ones. Additionally, the advantages of using earthen materials are also discussed for the different building life-cycle stages, focusing on the possibility to recycle these materials in a closed-loop approach.FEDER funds through the Competitivity and Internationalization Operational Programme (POCI) and by national funds through FCT—Foundation for Science and Technology within the scope of the project with the reference POCI-01-0145-FEDER-029328, and of the Ph.D. grant with the reference PD/BD/113641/2015, that were fundamental for the development of this study. The authors also wish to thank the construction company for providing the life cycle inventory data and helping this research wor

Calcium/Calmodulin Dependent Protein Kinase II Bound to NMDA Receptor 2B Subunit Exhibits Increased ATP Affinity and Attenuated Dephosphorylation

Calcium/calmodulin dependent protein kinase II (CaMKII) is implicated to play a key role in learning and memory. NR2B subunit of N-methyl-D-aspartate receptor (NMDAR) is a high affinity binding partner of CaMKII at the postsynaptic membrane. NR2B binds to the T-site of CaMKII and modulates its catalysis. By direct measurement using isothermal titration calorimetry (ITC), we show that NR2B binding causes about 11 fold increase in the affinity of CaMKII for ATPγS, an analogue of ATP. ITC data is also consistent with an ordered binding mechanism for CaMKII with ATP binding the catalytic site first followed by peptide substrate. We also show that dephosphorylation of phospho-Thr286-α-CaMKII is attenuated when NR2B is bound to CaMKII. This favors the persistence of Thr286 autophosphorylated state of CaMKII in a CaMKII/phosphatase conjugate system in vitro. Overall our data indicate that the NR2B- bound state of CaMKII attains unique biochemical properties which could help in the efficient functioning of the proposed molecular switch supporting synaptic memory

Phenotype Enhancement Screen of a Regulatory spx Mutant Unveils a Role for the ytpQ Gene in the Control of Iron Homeostasis

Spx is a global regulator of genes that are induced by disulfide stress in Bacillus subtilis. The regulon that it governs is comprised of over 120 genes based on microarray analysis, although it is not known how many of these are under direct Spx control. Most of the Spx-regulated genes (SRGs) are of unknown function, but many encode products that are conserved in low %GC Gram-positive bacteria. Using a gene-disruption library of B. subtilis genomic mutations, the SRGs were screened for phenotypes related to Spx-controlled activities, such as poor growth in minimal medium and sensitivity to methyglyoxal, but nearly all of the SRG mutations showed little if any phenotype. To uncover SRG function, the mutations were rescreened in an spx mutant background to determine which mutant SRG allele would enhance the spx mutant phenotype. One of the SRGs, ytpQ was the site of a mutation that, when combined with an spx null mutation, elevated the severity of the Spx mutant phenotype, as shown by reduced growth in a minimal medium and by hypersensitivity to methyglyoxal. The ytpQ mutant showed elevated oxidative protein damage when exposed to methylglyoxal, and reduced growth rate in liquid culture. Proteomic and transcriptomic data indicated that the ytpQ mutation caused the derepression of the Fur and PerR regulons of B. subtilis. Our study suggests that the ytpQ gene, encoding a conserved DUF1444 protein, functions directly or indirectly in iron homeostasis. The ytpQ mutant phenotype mimics that of a fur mutation, suggesting a condition of low cellular iron. In vitro transcription analysis indicated that Spx stimulates transcription from the ytpPQR operon within which the ytpQ gene resides. The work uncovers a link between Spx and control of iron homeostasis

A Study on the Level of Philosophical Intelligence Among Graduate Student Teachers of KeralaUn estudio sobre el nivel de inteligencia filosófica entre estudiantes de posgrado de profesores de Kerala

Philosophical intelligence refers to the ability to critically consider fundamental issues related to existence, values, knowledge, and purpose. It involves exploring abstract ideas, ethical dilemmas, and synthesizing different perspectives to form a coherent worldview. This intelligence promotes wisdom, introspection, and the ability to approach life’s challenges with logical discernment. The current study aimed to assess the philosophical intelligence of graduate student teachers in Kerala and examine if gender, location, or socioeconomic status influenced their philosophical intelligence. The study employed a quantitative approach, using a survey to assess the philosophical intelligence of graduate student teachers in Kerala. The sample was categorized by gender, location, and socioeconomic status to analyse potential differences. Data were analysed to determine the overall level of philosophical intelligence among participants and to identify any significant differences across the subgroups. The results indicated that the philosophical intelligence of graduate student teachers was average or mediocre. No significant differences in philosophical intelligence were found across the subgroups based on gender, location, or socioeconomic status. The findings suggest that the current teacher education curriculum should emphasize the practical application of diverse philosophical schools through creative assignments and practicums, rather than focusing solely on rote memorization of theoretical concepts. This approach could foster a deeper understanding and development of philosophical intelligence among student teachers.La inteligencia filosófica se refiere a la capacidad de considerar críticamente cuestiones fundamentales relacionadas con la existencia, los valores, el conocimiento y el propósito. Implica explorar ideas abstractas, dilemas éticos y sintetizar diferentes perspectivas para formar una visión del mundo coherente. Esta inteligencia promueve la sabiduría, la introspección y la capacidad de abordar los desafíos de la vida con discernimiento lógico. El presente estudio tuvo como objetivo evaluar la inteligencia filosófica de los profesores estudiantes de posgrado en Kerala y examinar si el género, la ubicación o el estatus socioeconómico influían en su inteligencia filosófica. El estudio empleó un enfoque cuantitativo, utilizando una encuesta para evaluar la inteligencia filosófica de los profesores estudiantes de posgrado en Kerala. La muestra se categorizó por género, ubicación y estatus socioeconómico para analizar posibles diferencias. Los datos se analizaron para determinar el nivel general de inteligencia filosófica entre los participantes y para identificar cualquier diferencia significativa entre los subgrupos. Los resultados indicaron que la inteligencia filosófica de los profesores estudiantes de posgrado era promedio o mediocre. No se encontraron diferencias significativas en la inteligencia filosófica entre los subgrupos basados en género, ubicación o estatus socioeconómico. Los hallazgos sugieren que el currículo actual de formación docente debería enfatizar la aplicación práctica de diversas escuelas filosóficas a través de tareas creativas y prácticas, en lugar de centrarse únicamente en la memorización de conceptos teóricos. Este enfoque podría fomentar una comprensión más profunda y el desarrollo de la inteligencia filosófica entre los estudiantes de formación docente