Multi-layer Tablet: Current scenario and recent advances

The purpose of this article on tableting of multiple Active Pharmaceutical Ingredients (APIs) in the single oral solid dose in the form of Fixed Dose Combinations (FDCs), that focused on therapeutic justification, designing, its practical approach, summarize the problem encountered and parameters to be considered during development. This will help budding formulation development scientists working on generic development as such types of formulation is current need in various disease conditions. Looking to the necessity of medical practitioners, ultimately generic pharmaceutical companies taking interest in development of such formulation with correct medical justification due to various health problem not only in India but also globally. FDCs are highly popular in the Indian pharmaceutical market and also have been seen in the last few years. Presently very few generic companies are working on FDCs in the form of multilayer tablets resulting into small numbers of formulation in the market yearly

Integration of green nanotechnology with silica for corrosion inhibition

Abstract Silica is a chemically inert molecule with an ability of adsorption on the metal to form a layer of barrier for preventing it from the atmospheric damage. However, a larger amount of silica is required for producing the impactful anticorrosive activity, leading to toxic and carcinogenic effects in the environment, and thus limiting the applications of silica. Application of nanotechnology in the synthesis of silica nanocomposites provides, for example, the advantages of better biocompatibility, systemic stability, ineffective response towards pH changes large multifunctionality. However, uses of harmful solvent, low penetration and toxicity, remain the major concerns for silica nanoparticles. Synthesis of silica nanocomposites with green technology will be an attractive approach to offer reduction in toxicity associated with the silica, higher surface area, effective penetration, easy spreadability, better adsorption over the metal surface and also provided the controlled release of chemical agents on contact with metal surface. The present article enlightens the use of green syntheses in the formulation of silica nanocomposites for corrosion inhibition in comparison to conventional synthetic method and provides the insights of various green nanocarriers such as nanocontainers, sol-to-gel nanoparticles, metallic nanostructures and silica nanocomposites for enhancing the proficiency of corrosion inhibition.</jats:p

Engineering of Nanospheres Dispersed Microneedle System for Antihypertensive Action

Background: A combinational therapy is mostly preferred in hypertension treatment because of low-dose and less side effects like pretibial edema, and gastrointestinal bleeding. Objective: So the objective of the present work was to formulate an advanced drug delivery system in the form of bio-responsive microneedles by incorporating nifedipine, a cardiodepressant and diltiazem, a vasodilator for effective synergism in the treatment of hypertension. Methods: The pH-responsive PLGA nanospheres of diltiazem were formulated using Water-in-Oil-in- Water (W/O/W) double emulsion and solvent-diffusion-evaporation technique. These nanospheres were added to nifedipine-PVP mixture and then incorporated into mold to develop microneedles. Results: The microneedles showed the release of nifedipine almost 96.93± 2.31% for 24 h due to high PVP solubilization. The nanospheres of diltiazem on contact with acidic pH of skin managed to form of CO2 bubbles and increase the internal pressure to burst PLGA shell due to pore formation. The mean blood pressure observed for the normal group was 89.58 ± 3.603 mmHg, whereas the treatment with the new formulation significantly reduced the mean blood pressure up to 84.11 ± 2.98 mmHg in comparison to the disease control group (109.9 ± 1.825 mm Hg). Conclusion: This system co-delivers the drugs nifedipine and diltiazem in hypertension and shows an advance alternative approach over conventional drug delivery system. </jats:sec

Integration of Internet of Things with Quantum Dots: A State-of-the-art of Medicine

Internet of Things (IoT) emerges as disruptive innovation and development in the fields of drug delivery and biomedical sciences using on-target active transportation, sensors, wearable devices, real-time diagnostics, etc. Semiconducting fluorescence emitting material, quantum dots on integration with IoT displayed interesting results in the healthcare sector, especially in hospitals and pathological laboratories. Presently, the integrated system is used to improve productivity without the interference of human and offer a cost-effective system. This integrated system can be used for the detection of various diseases like epilepsy, cancer, diabetes, etc., and various biomedical applications like energy storage, lights, sensor technology, light filters, etc. The integrated technology is implemented into the field of medicine for simplifying the approaches in therapeutics and diagnostic applications. The collected and analyzed data are further useful for healthcare professionals to find patient-centric solutions. Artificial Intelligence-aided IoT emerges as a novel technology for transmitting and securing health data. Despite some of the limitations like e-waste and the risk of hacking, an IoT-based QD system will be considered as a modern healthcare provider with life-saving products for enriching the medical quality and real-time accessibility. </jats:sec

Nanotech-based Food: An Initiative for Alternative Pharmaceuticals

Abstract: Nanotechnology opens many avenues in the food sector and offers applications associated with food production, processing, cultivation, and packaging. Nanofood employs nanotechniques like nano-encapsulation to conjugate various phytochemicals, antioxidants, probiotics, minerals, vitamins, etc., into nanovehicles. Food fortification strategies are implemented to incorporate nano-processed substances. Nanofood is mostly used for improving health and as a supplementation in various diseases ranging from liver diseases to neurodegenerative disorders. Here, we focus on recent studies that exhibit comparable results for nanofood and conventional medicines, subsiding the limitations of traditional therapies. Nanofood holds the potential for the management of various health problems and can be used as an alternative to medicine in clinical conditions, like cancers and inflammatory bowel disease. With further advances in nanotechnology and expansion in the scope of the current nanofood industry, in addition to proper regulations set in place, nanofood may offer a wide variety of advantages in terms of safety, long-term stability, etc. </jats:sec