Universal quantum information compression and degrees of prior knowledge

We describe a universal information compression scheme that compresses any pure quantum i.i.d. source asymptotically to its von Neumann entropy, with no prior knowledge of the structure of the source. We introduce a diagonalisation procedure that enables any classical compression algorithm to be utilised in a quantum context. Our scheme is then based on the corresponding quantum translation of the classical Lempel-Ziv algorithm. Our methods lead to a conceptually simple way of estimating the entropy of a source in terms of the measurement of an associated length parameter while maintaining high fidelity for long blocks. As a by-product we also estimate the eigenbasis of the source. Since our scheme is based on the Lempel-Ziv method, it can be applied also to target sequences that are not i.i.d.Comment: 17 pages, no figures. A preliminary version of this work was presented at EQIS '02, Tokyo, September 200

Regulated peristalsis into the acidic region of the _Drosophila_ larval midgut is controlled by a novel component of the Autonomic Nervous System

The underlying cellular and molecular mechanisms that regulate and coordinate critical physiological processes such as peristalsis are complex, often cryptic, and involve the integration of multiple tissues and organ systems within the organism. We have identified a completely novel component of the larval autonomic nervous system in the _Drosophila_ larval midgut that is essential for the peristaltic movement of food from the anterior midgut into the acidic region of the midgut. We have named this region the Superior Cupric Autonomic Nervous System or SCANS. Located at the junction of the anterior and the acidic portions of the midgut, the SCANS is characterized by a cluster of a novel neuro-enteroendocrine cells that we call Lettuce Head Cells, a valve, and two anterior muscular tethers to the dorsal gastric caeca. Using cell ablation and ectopic activation via expression of the _Chlamydomonas reinhardtii_ blue-light activated channelrhodopsin, we demonstrate that the SCANS and in particular the Lettuce Head Cells are both necessary and sufficient for peristalsis and perhaps serve a larger role by coordinating digestion throughout the anterior midgut with development and growth

EXPERIMENTAL PANEL FLUTTER RESULTS FOR SOME FLAT AND CURVED TITANIUM SKIN PANELS AT SUPERSONIC SPEEDS

Panel flutter results for flat and curved titanium skin panels at supersonic spee

Entanglement cost of generalised measurements

Bipartite entanglement is one of the fundamental quantifiable resources of quantum information theory. We propose a new application of this resource to the theory of quantum measurements. According to Naimark's theorem any rank 1 generalised measurement (POVM) M may be represented as a von Neumann measurement in an extended (tensor product) space of the system plus ancilla. By considering a suitable average of the entanglements of these measurement directions and minimising over all Naimark extensions, we define a notion of entanglement cost E_min(M) of M. We give a constructive means of characterising all Naimark extensions of a given POVM. We identify various classes of POVMs with zero and non-zero cost and explicitly characterise all POVMs in 2 dimensions having zero cost. We prove a constant upper bound on the entanglement cost of any POVM in any dimension. Hence the asymptotic entanglement cost (i.e. the large n limit of the cost of n applications of M, divided by n) is zero for all POVMs. The trine measurement is defined by three rank 1 elements, with directions symmetrically placed around a great circle on the Bloch sphere. We give an analytic expression for its entanglement cost. Defining a normalised cost of any d-dimensional POVM by E_min(M)/log(d), we show (using a combination of analytic and numerical techniques) that the trine measurement is more costly than any other POVM with d>2, or with d=2 and ancilla dimension 2. This strongly suggests that the trine measurement is the most costly of all POVMs.Comment: 20 pages, plain late

Rasch analysis of the illness management and recovery scale-clinician version

Rationale, aims and objectives The illness management and recovery scale-clinician version (IMRS-C) is a measure of outcomes thought to be important indicators of progress for consumers participating in illness management and recovery (IMR). Prior research has examined the psychometric properties of the IMRS-C; extant research supports certain aspects of the scale's reliability (test–retest) and validity (sensitivity to interventions). Analyses based on Rasch provide certain advantages and have not been applied to the IMRS-C. Method This study used an archival IMRS database including responses regarding 697 participants with severe mental illness from a variety of community-based settings. Rasch analyses were utilized to determine item functioning and utility of the IMRS-C. Results Results of Rasch analyses using the IMRS-C as one unidimensional scale were problematic. Analyses grouping items into three separate scales measuring recovery, management and biological vulnerability were more promising, but the third scale had other limitations. Conclusions Results suggest that the items included in the IMRS-C can form two screeners, one for recovery and one for management; items regarding biological vulnerability were inadequate. The assessment could be supplemented by more refined measures of coping/self-management and recovery constructs

A hybrid of bovine pancreatic ribonuclease and human angiogenin: an external loop as a module controlling substrate specificity?

A comparison of the sequences of three homologous ribonucleases (RNase A, angiogenin and bovine seminal RNase) identifies three surface loops that are highly variable between the three proteins. Two hypotheses were contrasted: (i) that this variation might be responsible for the different catalytic activities of the three proteins; and (ii) that this variation is simply an example of surface loops undergoing rapid neutral divergence in sequence. Three hybrids of angiogenin and bovine pancreatic ribonuclease (RNase) A were prepared where regions in these loops taken from angiogenin were inserted into RNase A. Two of the three hybrids had unremarkable catalytic properties. However, the RNase A mutant containing residues 63-74 of angiogenin had greatly diminished catalytic activity against uridylyl-(3′ - 5′)-adenosine (UpA), and slightly increased catalytic activity as an inhibitor of translation in vitro. Both catalytic behaviors are characteristic of angiogenin. This is one of the first examples of an engineered external loop in a protein. Further, these results are complementary to those recently obtained from the complementary experiment, where residues 59-70 of RNase were inserted into angiogenin [Harper and Vallee (1989) Biochemistry, 28, 1875-1884]. Thus, the external loop in residues 63-74 of RNase A appears to behave, at least in part, as an interchangeable ‘module' that influences substrate specificity in an enzyme in a way that is isolated from the influences of other regions in the protei

Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles.

Alcoholic liver disease (ALD) is a leading cause of cirrhosis in the United States, which is characterized by extensive deposition of extracellular matrix proteins and formation of a fibrous scar. Hepatic stellate cells (HSCs) are the major source of collagen type 1 producing myofibroblasts in ALD fibrosis. However, the mechanism of alcohol-induced activation of human and mouse HSCs is not fully understood. We compared the gene-expression profiles of primary cultured human HSCs (hHSCs) isolated from patients with ALD (n = 3) or without underlying liver disease (n = 4) using RNA-sequencing analysis. Furthermore, the gene-expression profile of ALD hHSCs was compared with that of alcohol-activated mHSCs (isolated from intragastric alcohol-fed mice) or CCl4-activated mouse HSCs (mHSCs). Comparative transcriptome analysis revealed that ALD hHSCs, in addition to alcohol-activated and CCl4-activated mHSCs, share the expression of common HSC activation (Col1a1 [collagen type I alpha 1 chain], Acta1 [actin alpha 1, skeletal muscle], PAI1 [plasminogen activator inhibitor-1], TIMP1 [tissue inhibitor of metalloproteinase 1], and LOXL2 [lysyl oxidase homolog 2]), indicating that a common mechanism underlies the activation of human and mouse HSCs. Furthermore, alcohol-activated mHSCs most closely recapitulate the gene-expression profile of ALD hHSCs. We identified the genes that are similarly and uniquely up-regulated in primary cultured alcohol-activated hHSCs and freshly isolated mHSCs, which include CSF1R (macrophage colony-stimulating factor 1 receptor), PLEK (pleckstrin), LAPTM5 (lysosmal-associated transmembrane protein 5), CD74 (class I transactivator, the invariant chain), CD53, MMP9 (matrix metallopeptidase 9), CD14, CTSS (cathepsin S), TYROBP (TYRO protein tyrosine kinase-binding protein), and ITGB2 (integrin beta-2), and other genes (compared with CCl4-activated mHSCs). Conclusion: We identified genes in alcohol-activated mHSCs from intragastric alcohol-fed mice that are largely consistent with the gene-expression profile of primary cultured hHSCs from patients with ALD. These genes are unique to alcohol-induced HSC activation in two species, and therefore may become targets or readout for antifibrotic therapy in experimental models of ALD