A crystalline incarnation of Berthelot's conjecture and K\"unneth formula for isocrystals

Berthelot's conjecture predicts that under a proper and smooth morphism of schemes in characteristic $p$, the higher direct images of an overconvergent $F$-isocrystal are overconvergent $F$-isocrystals. In this paper we prove that this is true for crystals up to isogeny. As an application we prove a K\"unneth formula for the crystalline fundamental group

On p-adic differential equations on semistable varieties

This is the author accepted manuscript. The final version is available from Springer Verlag via the DOI in this record.In this paper we prove a comparison theorem between the category of certain modules with integrable connection on the complement of a normal crossing divisor of the generic fiber of a proper semistable variety over a DVR and the category of certain log overconvergent isocystrals on the special fiber of the same open

Basi normali intere: risultati principali nel caso generale e sviluppi recenti nel caso abeliano.

Una base normale intera per un'estensione di campi di numeri L/K di Galois è una base dell'anello degli interi di L come modulo sull'anello degli interi di K costituita da elementi coniugati. Trovare una condizione necessaria e sufficiente per l'esistenza di una base normale intera di una data estenisione è un problema aperto. Se L/K è un'estensione di campi locali una condizione necessaria e sufficiente per l'esistenza di una base normale intera è che l'estensione sia tame. Nel caso di campi globali non è noto alcun risultato generale; si sa però che nel caso di estensioni abeliane dei razionali la ramificazione moderata basta a garantire l'esistenza di una tale base. Nell'ultima parte della tesi vengono studiate le estensioni L/K tali che K sia un campo ciclotomico e L un'estensione abeliana dei razionali: viene data una condizione necessaria e sufficiente perché una esista una base normale per queste particolari estensioni e viene definito un indice che misura quanto manca ad una tale estensione all'avere una base normale intera

Kernel of the monodromy operator for semistable curves

This is the final version of the article. Available from the publisher via the URL in this recordThis is an announcement of results, obtained in collaboration with B. Chiarellotto, R. Coleman and A. Iovita, whose proofs will be published elsewhere. We study the relation between the kernel of the monodromy operator acting on the first log crystalline cohomology group of the special fiber of a semistable curve and the first rigid cohomology group with non trivial coefficients

On p-adic differential equations on semistable varieties II

This is the author accepted manuscript. The final version is available from Springer Verlag via the DOI in this record.This paper is a complement to the paper "On p-adic differential equations on semistable varieties" written by V. Di Proietto. Given an open variety over a DVR with semistable reduction, the author constructed in that paper a fully faithful algebraization functor from the category of certain log overconvergent isocrystals on the special fiber to the category of modules with regular integrable connection on the generic fiber. In this paper, we prove that, with convenable hypothesis, this functor is a tensor functor whose essential image is closed under extensions and subquotients. As a consequence, we can find suitable Tannakian subcategories of log overconvergent isocrystals and of modules with regular integrable connection on which the algebraization functor is an equivalence of Tannakian categories.The main part of this work was done when the first author was at the Graduate School of Mathematical Sciences of the University of Tokyo supported by a postdoctoral fellowship and kaken-hi (grant-in-aid) of the Japanese Society for the Promotion of Science (JSPS). She is now supported by a postdoctoral fellowship of Labex IRMIA.When the main part of this work was done, the second author was supported by JSPS Grant-in-Aid for Young Scientists (B) 21740003 and Grant-in-Aid for Scientific Research (B) 22340001. Currently he is supported by JSPS Grant-in-Aid for Scientific Research (C) 25400008 and Grant-in-Aid for Scientific Research (B) 23340001

Epigenetic and posttranslational modifications in light signal transduction and the circadian clock in Neurospora crassa

Blue light, a key abiotic signal, regulates a wide variety of physiological processes in many organisms. One of these phenomena is the circadian rhythm presents in organisms sensitive to the phase-setting effects of blue light and under control of the daily alternation of light and dark. Circadian clocks consist of autoregulatory alternating negative and positive feedback loops intimately connected with the cellular metabolism and biochemical processes. Neurospora crassa provides an excellent model for studying the molecular mechanisms involved in these phenomena. The White Collar Complex (WCC), a blue-light receptor and transcription factor of the circadian oscillator, and Frequency (FRQ), the circadian clock pacemaker, are at the core of the Neurospora circadian system. The eukaryotic circadian clock relies on transcriptional/translational feedback loops: some proteins rhythmically repress their own synthesis by inhibiting the activity of their transcriptional factors, generating self-sustained oscillations over a period of about 24 h. One of the basic mechanisms that perpetuate self-sustained oscillations is post translation modification (PTM). The acronym PTM generically indicates the addition of acetyl, methyl, sumoyl, or phosphoric groups to various types of proteins. The protein can be regulatory or enzymatic or a component of the chromatin. PTMs influence protein stability, interaction, localization, activity, and chromatin packaging. Chromatin modification and PTMs have been implicated in regulating circadian clock function in Neurospora. Research into the epigenetic control of transcription factors such as WCC has yielded new insights into the temporal modulation of light-dependent gene transcription. Here we report on epigenetic and protein PTMs in the regulation of the Neurospora crassa circadian clock. We also present a model that illustrates the molecular mechanisms at the basis of the blue light control of the circadian clock

Coinfection by Ureaplasma spp., Photobacterium damselae and an Actinomyces-like microorganism in a bottlenose dolphin (Tursiops truncatus) with pleuropneumonia stranded along the Adriatic coast of Italy

A case of pleuropneumonia is reported in an adult male bottlenose dolphin (Tursiops truncatus) found stranded in 2014 along the Central Adriatic coast of Italy. A severe pyogranulomatous pneumonia and thoracic lymphadenopathy were present at necropsy. Numerous Splendore-Hoeppli bodies were found microscopically scattered throughout the lung. Histochemical evidence of Actinomyces-like organisms was obtained from the pulmonary parenchyma, with a strain of Photobacterium damselae subsp. piscicida and Ureaplasma spp. being also isolated from the same tissue. For the latter, a genome fragment of approximately 1400 bp from the 16s rDNA was amplified and sequenced. BLAST analysis revealed 100% identity with an uncultured Ureaplasma spp. (JQ193826.1)