Authenticating the Query Results of Text Search Engines

The number of successful attacks on the Internet shows that it is very difficult to guarantee the security of online search engines. A breached server that is not detected in time may return incorrect results to the users. To prevent that, we introduce a methodology for generating an integrity proof for each search result. Our solution is targeted at search engines that perform similarity-based document retrieval, and utilize an inverted list implementation (as most search engines do). We formulate the properties that define a correct result, map the task of processing a text search query to adaptations of existing threshold-based algorithms, and devise an authentication scheme for checking the validity of a result. Finally, we confirm the efficiency and practicality of our solution through an empirical evaluation with real documents and benchmark queries. 1

Evaluation of a genetically modified foot-and-mouth disease virus vaccine candidate generated by reverse genetics

<p>Abstract</p> <p>Background</p> <p>Foot-and-mouth disease (FMD) is the most economically important and highly contagious disease of cloven-hoofed animals worldwide. Control of the disease has been mainly based on large-scale vaccinations with whole-virus inactivated vaccines. In recent years, a series of outbreaks of type O FMD occurred in China (including Chinese Taipei, Chinese Hong Kong) posed a tremendous threat to Chinese animal husbandry. Its causative agent, type O FMDV, has evolved into three topotypes (East–South Asia (ME-SA), Southeast Asia (SEA), Cathay (CHY)) in these regions, which represents an important obstacle to disease control. The available FMD vaccine in China shows generally good protection against ME-SA and SEA topotype viruses infection, but affords insufficient protection against some variants of the CHY topotype. Therefore, the choice of a new vaccine strain is of fundamental importance.</p> <p>Results</p> <p>The present study describes the generation of a full-length infectious cDNA clone of FMDV vaccine strain and a genetically modified virus with some amino acid substitutions in antigenic sites 1, 3, and 4, based on the established infectious clone. The recombinant viruses had similar growth properties to the wild O/HN/CHA/93 virus. All swine immunized with inactivated vaccine prepared from the O/HN/CHA/93 were fully protected from challenge with the viruses of ME-SA and SEA topotypes and partially protected against challenge with the virus of CHY topotype at 28 days post-immunization. In contrast, the swine inoculated with the genetically modified vaccine were completely protected from the infection of viruses of the three topotypes.</p> <p>Conclusions</p> <p>Some amino acid substitutions in the FMDV vaccine strain genome did not have an effect on the ability of viral replication in vitro. The vaccine prepared from genetically modified FMDV by reverse genetics significantly improved the protective efficacy to the variant of the CHY topotype, compared with the wild O/HN/CHA/93 virus. Thus, the full-length cDNA clone of FMDV can be a useful tool to develop genetically engineered FMDV vaccine candidates to help control porcinophilic FMD epidemics in China.</p