Plethysmography system to monitor the jugular venous pulse: A feasibility study

Cerebral venous outflow is investigated in the diagnosis of heart failure through the monitoring of jugular venous pulse, an indicator to assess cardiovascular diseases. The jugular venous pulse is a weak signal stemming from the lying internal jugular vein and often invasive methodolo-gies requiring surgery are mandatory to detect it. Jugular venous pulse can also be extrapolated via the ultrasound technique, but it requires a qualified healthcare operator to perform the exami-nation. In this work, a wireless, user-friendly, wearable device for plethysmography is developed to investigate the possibility of monitoring the jugular venous pulse non-invasively. The proposed device can monitor the jugular venous pulse and the electrocardiogram synchronously. To study the feasibility of using the proposed device to detect physiological variables, several measurements were carried out on healthy subjects by considering three different postures: supine, sitting, and upright. Data acquired in the experiment were properly filtered to highlight the cardiac oscillation and remove the breathing contribution, which causes a considerable shift in the amplitude of signals. To evaluate the proper functioning of the wearable device for plethysmography, a comparison with the ultrasound technique was carried out. As a satisfactory result, the acquired signals resemble the typical jugular venous pulse waveforms found in literature

On the Persistence of Mental Health Deterioration during the COVID-19 Pandemic by Sex and Ethnicity in the UK: Evidence from Understanding Society

This is the final version. Available on open access from De Gruyter via the DOI in this recordData and code availability: The research data are distributed by the UK Data Service. Researchers who would like to use Understanding Society need to register with the UK Data Service before being allowed to apply for or download datasets. More information: https://www.understandingsociety.ac.uk/documentation/access-data. The code to replicate the analysis in this letter is publicly available from the Harvard Dataverse repository: https://doi.org/10.7910/DVN/YUOWJEWe use longitudinal data from a representative sample of the UK and compare self-reported mental health, as measured by the GHQ-12 score, at three timepoints (2017–2019, April 2020 and March 2021), for the whole sample and by sex and ethnicity. Out of the 14,382 individuals interviewed in 2017–2019 and April 2020, 10,445 were interviewed again in March 2021. The mean GHQ-12 in April 2020 is 12.37 [95% CI: 12.22, 12.52] and in March 2021 is 12.36 [95% CI: 12.21, 12.51], above that of 2017–2019: 11.13 [95% CI: 10.99, 11.26]. We do not find evidence that the level of mental health goes back to pre-pandemic levels. In terms of inequalities, while the gender gap (mean difference between women and men) in mental health deterioration among White British is closing, there is no clear evidence that the ethnic gap (mean difference between ethnic minorities and White British) among men is changing

Physics potential of a long-baseline neutrino oscillation experiment using a J-PARC neutrino beam and Hyper-Kamiokande

39 pages, 26 figures, submitted to PTE

Plasma activated water as resistance inducer against bacterial leaf spot of tomato

Plant bacterial diseases are routinely managed with scheduled treatments based on heavy metal compounds or on antibiotics; to reduce the negative environmental impact due to the use of such chemical compounds, as pollution or selection of antibiotic resistant pathogens, the integrated control management is required. In the frame of a sustainable agriculture the use of bacterial antagonists, biological agents, plant defence response elicitors or resistant host plant genotypes are the most effective approaches. In this work, cold atmospheric pressure plasma (CAP) was applied to sterile distilled water, inducing the production of a hydrogen peroxide, nitrite and nitrate, and a pH reduction. In particular, an atmospheric pressure dielectric barrier discharge (DBD) has been used to produce plasma activated water (PAW), that was firstly assayed in in vitro experiments and then in planta through application at the root apparatus of tomato plants, against Xanthomonas vesicatoria (Xv), the etiological agent of bacterial leaf spot. Moreover, the transcription abundance of five genes related to the plant defense was investigated in response to PAW treatment. PAW did not show direct antimicrobial activity against Xv in in vitro experiments, but it enhanced the tomato plants defenses. It was effective in reducing the disease severity by giving relative protections of ca. 61, 51 and 38% when applied 1 h, 24 h and 6 days before the experimental inoculation, respectively. In addition, the experiments highlighted the pal gene involvement in response to the PAW treatments and against the pathogen; its transcription levels resulted significantly high from 1 to 48 h until their decrease 192 h after PAW application

The <i>N</i>-myristoylome of <i>Trypanosoma cruzi</i>

Protein N-myristoylation is catalysed by N-myristoyltransferase (NMT), an essential and druggable target in Trypanosoma cruzi, the causative agent of Chagas’ disease. Here we have employed whole cell labelling with azidomyristic acid and click chemistry to identify N-myristoylated proteins in different life cycle stages of the parasite. Only minor differences in fluorescent-labelling were observed between the dividing forms (the insect epimastigote and mammalian amastigote stages) and the non-dividing trypomastigote stage. Using a combination of label-free and stable isotope labelling of cells in culture (SILAC) based proteomic strategies in the presence and absence of the NMT inhibitor DDD85646, we identified 56 proteins enriched in at least two out of the three experimental approaches. Of these, 6 were likely to be false positives, with the remaining 50 commencing with amino acids MG at the N-terminus in one or more of the T. cruzi genomes. Most of these are proteins of unknown function (32), with the remainder (18) implicated in a diverse range of critical cellular and metabolic functions such as intracellular transport, cell signalling and protein turnover. In summary, we have established that 0.43–0.46% of the proteome is N-myristoylated in T. cruzi approaching that of other eukaryotic organisms (0.5–1.7%)

Uncovering genetic parameters and environmental influences on fertility, milk production, and quality in autochthonous Reggiana cattle

Reggiana is a local cattle breed from northern Italy known for its rusticity and profitability, due to the production of branded Parmigiano Reggiano cheese. To ensure the persistence of such profitability in the long term, an adequate breeding program is required. To this aim, in the present study we estimate the genetic parameters of the main productive and reproductive traits, and we evaluate the effect of genotype by environment interaction (GxE) on these traits using 2 environmental covariates: (1) productivity and (2) temperature-humidity index (THI). Milk, fat, protein, and casein yield were considered as daily production traits, whereas protein, fat, casein percentage, casein index, and somatic cell score were considered as milk quality traits. Finally, reproductive traits such as the number of inseminations, days open, calving interval, and calving-to-first-insemination interval were evaluated. Reggiana cattle produce an average of 19 kg of milk per day with 3.7% fat and 3.4% protein content and have excellent fertility parameters. Compared with other breeds, they have slightly lower heritability for production and quality for production traits (e.g., 0.12 [0.09; 0.15] for milk yield), but similar heritability for fertility traits. Milk, protein, and fat daily yields are highly correlated but negatively correlated with the percentage of protein, fat, and casein, whereas fertility traits have an unfavorable genetic correlation with daily production traits. When considering productivity, a consistent amount of variability due to GxE was observed for all daily production traits, somatic cell count, and casein index. A modest amount of GxE was observed for fertility parameters, while the percentage of solid content showed almost no GxE effect. A similar situation occurred when considering the THI, but no GxE interaction was observed for reproduction traits. In conclusion, this study provides useful information for the implementation of accurate selection plans in this local breed, accounting for environmental plasticity measured through the consistent GxE interaction observed

A data-driven energy platform: from energy performance certificates to human-readable knowledge through dynamic high-resolution geospatial maps

The energy performance certificate (EPC) is a document that certifies the average annual energy consumption of a building in standard conditions and allows it to be classified within a so-called energy class. In a period such as this, when greenhouse gas emissions are of considerable importance and where the objective is to improve energy security and reduce energy costs in our cities, energy certification has a key role to play. The proposed work aims to model and characterize residential buildings’ energy efficiency by exploring heterogeneous, geo-referenced data with different spatial and temporal granularity. The paper presents TUCANA (TUrin Certificates ANAlysis), an innovative data mining engine able to cover the whole analytics workflow for the analysis of the energy performance certificates, including cluster analysis and a model generalization step based on a novel spatial constrained K-NN, able to automatically characterize a broad set of buildings distributed across a major city and predict different energy-related features for new unseen buildings. The energy certificates analyzed in this work have been issued by the Piedmont Region (a northwest region of Italy) through open data. The results obtained on a large dataset are displayed in novel, dynamic, and interactive geospatial maps that can be consulted on a web application integrated into the system. The visualization tool provides transparent and human-readable knowledge to various stakeholders, thus supporting the decision-making process

State of the Art and New Trends from the 2022 Gism Annual Meeting

The 2022 Italian Mesenchymal Stem Cell Group (Gruppo Italiano Staminali Mesenchimali, GISM) Annual Meeting took place on 20–21 October 2022 in Turin (Italy), with the support of the University of Turin and the City of Health and Science of Turin. The novelty of this year’s meeting was its articulation, reflecting the new structure of GISM based on six sections: (1) Bringing advanced therapies to the clinic: trends and strategies, (2) GISM Next Generation, (3) New technologies for 3D culture systems, (4) Therapeutic applications of MSC-EVs in veterinary and human medicine, (5) Advancing MSC therapies in veterinary medicine: present challenges and future perspectives, (6) MSCs: a double-edged sword: friend or foe in oncology. National and international speakers presented their scientific works with the aim of promoting an interactive discussion and training for all attendees. The atmosphere was interactive, where ideas and questions between younger researchers and senior mentors were shared in all moments of the congress

Un anno di Comitato Unico di Garanzia: riflessioni all'INGV

L’Istituto Nazionale di Geofisica e Vulcanologia - INGV ha istituito il Comitato Unico di Garanzia per le pari opportunità, la valorizzazione del benessere di chi lavora e contro le discriminazioni – CUG nel luglio 2011, ai sensi della L.183/2010. Il CUG ha assunto, estendendoli, i compiti del precedente Comitato Pari Opportunità, ossia, come da delibera CD n.4.3.2.11 del 28/6/2011: • focalizzare i problemi relativi alle pari opportunità; • contribuire a migliorare la qualità della vita negli ambienti di lavoro e a valorizzare le risorse umane; • verificare gli equilibri tra i sessi nelle posizioni funzionali a parità di requisiti professionali; • formulare proposte per: la gestione flessibile delle risorse umane e le attività di formazione professionale; è inoltre chiamato a perseguire gli obiettivi della direttiva dei dipartimenti della Funzione Pubblica e per le Pari Opportunità del 4 marzo 2011, per esercitare compiti propositivi, consultivi e di verifica. I compiti affidati dall’Amministrazione da un lato e le sollecitazioni ricevute dal personale dall’altro hanno portato ad una serie di azioni, tra le principali: • la redazione di un Codice per la tutela della dignità delle persone e per la prevenzione delle molestie sessuali e morali dell’INGV, l’individuazione della Consigliera di Fiducia e l’avvio di un ciclo di seminari sull’argomento, nell’ambito della prevenzione delle discriminazioni; • una lettura di genere delle bozze dei nuovi regolamenti dell’ente, con proposte di modifiche ispirate alla Carta Europea dei Ricercatori – CdR (e.g. principi di Non discriminazione, Equilibrio di genere) e alla normativa in tema di pari opportunità e tutela della maternità, parte delle quali recepite nel Regolamento del Personale e nel Disciplinare in materia di orario di servizio; un’azione, questa, legata all’adesione in via sperimentale alla Human Resources Strategy for Researchers, iniziativa della Comunità Europea per l’effettiva implementazione della CdR; • nell’ambito del processo di valutazione della ricerca dell’ANVUR, l’evidenziazione di alcune criticità presenti nel bando, in relazione alla valutazione della maternità, risultate in una interrogazione parlamentare e in una lettera aperta, grazie al contributo dell’Associazione Donne e Scienza e dei CUG dell’INFN e del CNR. Le esperienze fatte confermano l’opportunità di dare voce a tutte le donne dell’Istituto e di fare rete tra i Comitati degli enti di ricerca.UnpublishedCertosa di Pontignano (Siena), Italyope