Social policy as a factor in employment regulation in the labor market of Russia

The article considers the problems of forming an optimal social policy that would allow building a more effective employment policy in the Russian labor market. The social policy of the state should ensure social stability, contribute to the equalization of the incomes of the population in the sectoral and regional sections, but not generate a class of dependents who can exist exclusively on state benefits.The author considers the structure of employment of the population, which determines the existing contradictions in the tax, pension and social systems. The paper analyzes the problems of the Russian labor market that have developed over many years of the market economy.The author notes the social orientation of the state in its budget policy, the share of social expenditures is growing, but in many respects they are tactical in nature.There is a need to revise the current social policy in the country on the basis of reforming the taxation system

Получение и изучение свойств противоопухолевого лекарственного средства на основе липидного производного сарколизина

The conditions for the preparation of a drug formulations based on the lipid derivative of sarcolysin embedded in phospholipid nanoparticles have been optimized. The drug is an ultra-thin emulsion with a light transmittance above 80% and a particle size of not more than 50 nm. It should be noted that 99% of the lipid derivative of sarcolysin are incorporated into phospholipid nanoparticles. Preservation of aggregation stability in the aquatic environment was observed for at least 2 days. In vitro experiments have shown that sarcolysin, introduced as a part of phospholipid nanoparticles, is distributed among lipoproteins and protein components of plasma. Moreover, the content of sarcolysin in all fractions involved in the transport of biologically active substances in the body, is significantly higher in case of prodrug administration (lipid derivative of sarcolysin) in the composition of phospholipid nanoparticles than, as compared with administration of a free form (pharmacological substances) to the incubation medium. The transformation of a prodrug into the drug sarcolysin occurs in the blood cells.Оптимизированы условия получения лекарственного средства на основе липидного производного сарколизина, встроенного в фосфолипидные наночастицы. Препарат представляет собой ультратонкую эмульсию со светопропусканием выше 80% и размером частиц не более 50 нм. При этом 99% липидного производного сарколизина встроено в фосфолипидные наночастицы. Сохранение агрегационной устойчивости в водной среде наблюдалось как минимум в течение 2-х суток. Эксперименты in vitro показали, что сарколизин, введенный в составе фосфолипидных наночастиц, распределяется по липопротеинам и белковым компонентам плазмы крови. При этом содержание сарколизина во всех фракциях, участвующих в транспорте биологически активных веществ в организме, значительно выше при введении в виде пролекарства (липидного производного сарколизина) в составе фосфолипидных наночастиц, чем при введении сарколизина в инкубационную среду в свободном виде (т.е. фармакологической субстанции). Превращение пролекарства в лекарство сарколизин происходит в клетках форменных элементов

North Korea: What is the Direction of Further Evolution

The article analyzes the changes that have occurred in the DPRK economy during the years of Kim Jong-un&amp;apos;s rule. The article considers the significant shifts that have taken place in the direction of a market economy, both in industry and in agriculture. At the same time, it is noted that market innovations are officially presented under the guise of elements of self-financing and the further development of socialism. Not all of the functioning market schemes have received the appropriate legislative formalization and, thus, remain illegal, although they are widely used in practice. Nevertheless, the country has been successfully developing for a number of years, demonstrating steady economic growth, a construction boom, the widespread introduction of information technologies, as well as significant progress in rocket science and the improvement of the nuclear arsenal. Numerous missile tests in 2017 led to a sharp aggravation of the situation on the peninsula, tightening of international sanctions, slowing down development and freezing further &amp;quot;reforms&amp;quot;. Kim Jong-un&amp;apos;s attempts to find a way out of the current situation through initiating a negotiation process with the ROK and the United States undoubtedly contributed to reducing tension in the region, however, in general, they were not crowned with success. The course to create a self-sufficient economy with the appearance of the threat of COVID-19 was accomplished with a regime of severe self-isolation. In conclusion, considerations are expressed regarding the ways of further development of North Korea. It is predicted that the role of the state will increase in the economic life of the country, which, after a series of successes and achievements, has found itself in the most difficult situation in the last twenty years.</jats:p

On the treatment of septic endocarditis with large doses of polyvalent anti-streptococcal serum

In the present report, we will dwell on the description of several cases of septic heart lesions, in which we used polyvalent anti-streptococcal serum in high doses, and share observations on its action.If this serum has been successfully used and is used by many people for rye, postpartum fever and some other septic lesions, in endocarditis it is used very rarely, and the available literature data on this subject speak mostly not in favor of such treatment.</jats:p

[Proceedings of the 4th International Workshop of the Lower Cretaceous Cephalopod Team (IGCP-Project 362) / Peter F. Rawson and Philip J. Hoedemaeker (editors)]: Substantiation of the Barremian/Aptian boundary

This paper focuses on the Barremian/Aptian boundary in the Trans-Caspian area. Results of a stratigraphical study of the uppermost Barremian and the lower Aptian succession in the Trans-Caspian area are presented. The bed-by-bed description of three sections — Keldzhe, Tekedzhik and Utuludzha — is given as well as detailed lithologic columns. Five ammonite zones are known in the studied stratigraphic interval — the Turkmeniceras turkmenicum, Deshayesites tuarkyricus, D. weissi, D. deshayesi, and Dufrenoya furcata zones. These zones are correlated with those of Europe. The Barremian/Aptian boundary in the Trans-Caspian area should be drawn at the base of the D. tuarkyricus Zone. It corresponds to the layers with the first occurrences of Deshayesites, Prodeshayesites and Paradeshayesites in Europe. It is proposed here to situate the boundary stratotype in the Utuludzha section, where the beds containing zonal representatives of the T. turkmenicum and D. tuarkyricus Zones are almost adjacent