International Quota Transfer and Intermediate Goods

In this paper we use a general equilibrium model to examine the effects of international quota transfer when a quota restricts world commodity production whilst the trade in an intermediate good is not regulated. The analysis shows that, when the quota regime is not internationally transferable, intermediate input trade substitutes for final good trade. In these circumstances, the distortions are lower than expected. International quota transfer increases world welfare proportionally to quota rent gap. Welfare distribution is also conditioned by commodity terms of trade and, particularly, by the outcome of the intermediate good price.Production quota, international trade, intermediate goods, International Relations/Trade,

Relación entre el consumo problemático de drogas y distintas variables socioeconómicas, sociodemográficas y ambientales en la ciudad de Barcelona

El consumo de drogas es una cuestión de salud pública muy sensible a la estructura urbana. Se ha asociado con múltiples problemas orgánicos, mentales y sociales. Sin embargo, es un fenómeno difícil de monitorizar, ya que la población consumidora de drogas se halla oculta en la sociedad. Por ello, se requieren indicadores indirectos para estimar la magnitud global del problema. Así, el presente estudio crea y evalúa un índice de consumo problemático de drogas en cada uno de los 73 barrios de la ciudad de Barcelona y estima su grado de asociación con diferentes determinantes socioeconómicos, sociodemográficos y ambientales.El consum de drogues és una qüestió de salut pública molt sensible a l'estructura urbana. S'ha associat amb múltiples problemes orgànics, mentals i socials. No obstant això, és un fenomen difícil de monitoritzar, ja que la població consumidora de drogues es troba oculta a la societat. Per això, es requereixen indicadors indirectes per estimar la magnitud global del problema. El present estudi crea i avalua un índex de consum problemàtic de drogues en cada un dels 73 barris de la ciutat de Barcelona, i estima el grau d'associació amb diferents determinants socioeconòmics, sociodemogràfics i ambientals

X-ray detection with a scintillating YAP-window hybrid photomultiplier tube

A YAP(YAlO/sub 3/:Ce)-scintillating window, coated on its inner surface with an S20-photocathode, seals a cross-focusing hybrid photomultiplier tube (HPMT) equipped with a small p-i-n anode of 2-mm diameter. This new radiation detector separates X-ray lines down to about 2-keV peak energy from the HPMT noise. Its detection efficiency for high gamma energies depends on the YAP-window thickness and amounts to about 18% attenuation at 400-keV energy in the present version. Competitive radiation detectors like Si photodiodes and Si drift chambers are discussed and compared to our prototype, with particular attention given to their energy resolution and noise performance, which limits their active area considerably. (19 refs)

An ISPA-camera for gamma rays

With the recently developed ISPA (Imaging Silicon Pixel Array)-tube attached either to a planar YAlO3(Ce) (YAP) disc (1mm thick) or to a matrix of optically-separated YAP-crystals (5mm high, 0.6 x 0.6 mm2 cross-section) we achieved high spatial resolution of 57Co-122 keV photons. The vacuum-sealed ISPA-tube is only 4 cm long with 3.5 cm diameter and consists of a photocathode viewed at 3 cm distance by a silicon pixel chip, directly detecting the photoelectrons. The chip-anode consists of 1024 rectangular pixels with 75 µm x 500 µm edges, each bump-bonded to their individual front-end electronics. The total pixel array read-out time is 10 µs. The measured intrinsic spatial resolutions (FWHM) of this ISPA-camera are 700 µm (planar YAP) and 310 µm (YAP-matrix). Apart from its already demonstrated application for particle tracking with scintillating fibres, the ISPA-tube provides also an excellent tool in medicine, biology and chemistry

Spheroid Culture of Head and Neck Cancer Cells Reveals an Important Role of EGFR Signalling in Anchorage Independent Survival

In solid tumours millions of cells are shed into the blood circulation each day. Only a subset of these circulating tumour cells (CTCs) survive, many of them presumable because of their potential to form multi-cellular clusters also named spheroids. Tumour cells within these spheroids are protected from anoikis, which allows them to metastasize to distant organs or re-seed at the primary site. We used spheroid cultures of head and neck squamous cell carcinoma (HNSCC) cell lines as a model for such CTC clusters for determining the role of the epidermal growth factor receptor (EGFR) in cluster formation ability and cell survival after detachment from the extra-cellular matrix. The HNSCC cell lines FaDu, SCC-9 and UT-SCC-9 (UT-SCC-9P) as well as its cetuximab (CTX)-resistant sub-clone (UT-SCC-9R) were forced to grow in an anchorage- independent manner by coating culture dishes with the anti-adhesive polymer poly-2-hydroxyethylmethacrylate (poly-HEMA). The extent of apoptosis, clonogenic survival and EGFR signalling under such culture conditions was evaluated. The potential of spheroid formation in suspension culture was found to be positively correlated with the proliferation rate of HNSCC cell lines as well as their basal EGFR expression levels. CTX and gefitinib blocked, whereas the addition of EGFR ligands promoted anchorage-independent cell survival and spheroid formation. Increased spheroid formation and growth were associated with persistent activation of EGFR and its downstream signalling component (MAPK/ERK). Importantly, HNSCC cells derived from spheroid cultures retained their clonogenic potential in the absence of cell-matrix contact. Addition of CTX under these conditions strongly inhibited colony formation in CTX- sensitive cell lines but not their resistant subclones. Altogether, EGFR activation was identified as crucial factor for anchorage-independent survival of HNSCC cells. Targeting EGFR in CTC cluster formation might represent an attractive anti-metastatic treatment approach in HNSCC

A HPMT based set-up to characterize scintillating crystals

We have developed a fully automatic measurement set-up, capable of measuring light yields arising from scintillating crystals in a linear range of about four orders of magnitude. The photodetector is a Hybrid Photomultiplier Tube especially developed to optimize linear range and photon detection. Crystal and photodetector are temperature controlled by a closed water circuit, as this is essential when measuring low light yield scintillating crystals with a marked temperature dependence of their light yield. Gamma sources can be placed either on top or on the side of the crystal. In this latter case, the source can be automatically moved by a computer-controlled step motor to provide a uniformity profile of the light yield along the crystal. Tagged and not-tagged operation modes are possible. The whole set-up is computer-controlled in an effort to provide fast and reliable measurements, to characterize many crystals per day. This is important for the quality control of the Lead Tungstate crystals that will be applied in the electromagnetic calorimeter of the CMS-detector at the LHC at CERN