Chronic Q fever presenting as bilateral extensor tenosynovitis: a case report and review of the literature

Musculoskeletal manifestations of Coxiella burnetii are rare. We describe an elderly, immunosuppressed male with bilateral Coxiella burnetii extensor tenosynovitis treated with incision and debridement and chronic doxycycline and hydroxychloroquine. Additionally, disease etiology, risk factors, pertinent features of the history, testing modalities, and treatment strategies of musculoskeletal Q fever are reviewed.</p

Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism

One-carbon metabolism is an essential branch of cellular metabolism that intersects with epigenetic regulation. In this work, we show how formaldehyde (FA), a one-carbon unit derived from both endogenous sources and environmental exposure, regulates one-carbon metabolism by inhibiting the biosynthesis of S-adenosylmethionine (SAM), the major methyl donor in cells. FA reacts with privileged, hyperreactive cysteine sites in the proteome, including Cys120 in S-adenosylmethionine synthase isoform type-1 (MAT1A). FA exposure inhibited MAT1A activity and decreased SAM production with MAT-isoform specificity. A genetic mouse model of chronic FA overload showed a decrease n SAM and in methylation on selected histones and genes. Epigenetic and transcriptional regulation of Mat1a and related genes function as compensatory mechanisms for FA-dependent SAM depletion, revealing a biochemical feedback cycle between FA and SAM one-carbon units

Why design history? : A multi-national perspective on the state and purpose of the field

This article asks: what is the significance of design history within higher education? It reviews the practice and purpose of design history, in terms of its role in the education of historically aware and critically engaged designers, as an emerging independent discipline, and in terms of what the subject has to offer allied fields such as history, sociology, cultural studies, area studies and anthropology. It considers the development and current state of design history as it is taught in the UK and wider Europe, the US, Australia, and Japan, China and Korea. The argument that follows is grounded in recent design historical scholarship in order to provide both a contemporary perspective on current practice and suggestions about possible futures.Peer reviewe

Culture Jam Pedagogy and Practice: Relocating Culture by Staying on One's Toes

We illustrate how culture jam practitioners and pedagogues are responding to increasing commercial incorporation by using participatory communication strategies to bring the act of jamming back into the realm of relocating culture. We analyze the past decade's evolution of one of YouTube's first viral videos, “Where the hell is Matt?,” and connect this case to ways university pedagogy might integrate culture jams as artifacts and assignments to empower students to use communication frameworks not only to critique the status quo but also to collaboratively generate transformation. Throughout, we elucidate culture jam processes as creative and cooperative performances of staying on one's toes in the perpetual renegotiation of hegemony