Lawsonia intracellularis infection and proliferative enteropathy in foals.

Equine proliferative enteropathy (EPE) is a disease of foals caused by the obligate intracellular organism Lawsonia intracellularis. This organism is unique in that it causes proliferation of infected enterocytes, resulting in thickening of the intestinal epithelium, most often the small intestine. This disease affects mainly weanling foals and causes fever, lethargy, peripheral edema, diarrhea, colic and weight loss. The diagnosis of EPE may be challenging and relies on the presence of hypoproteinemia, thickening of segments of the small intestinal wall observed on abdominal ultrasonography, positive serology and molecular detection of L. intracellularis in feces. The epidemiology and genetic basis for pathogenesis for this disease is beginning to be elucidated. Phenotypic traits, genomic features, and gene expression profiles during L. intracellularis infection in vitro and in vivo are presented. In addition, this article reviews the epidemiology, pathological and clinicopathological findings, diagnosis, and control of EPE

Relativistic Stern-Gerlach Interaction in an RF Cavity

The general expression of the Stern-Gerlach force is deduced for a relativistic spin-1/2 particle which travels inside a time varying magnetic field. This result was obtained either by means of two Lorentz boosts or starting from Dirac's equation. Then, the utilization of this interaction for attaining the spin states separation is reconsidered in a new example using a new radio-frequency arrangement.Comment: 12 pages, 4 figure

L' Inferno è non essere gli altri. Scrittura poetica, traduzione e metamorfosi dell'io

Confine o frontiera? I due termini sono sinonimi, oppure indicano due modalità persino opposte di stabilire una linea divisoria? E quale rapporto esiste tra la valenza metaforica, spesso legata al mito e all'avventura, del concetto di «confine», e la sua materializzazione concreta come frontiere, poliziesca o militare? L'autore sviluppa questi interrogativi a partire dalla propria esperienza biografica e familiare; estendendo poi la perlustrazione a un altro tipo di confine: quello linguistico e culturale. La traduzione letteraria come possibilità di superare questo confine, e di riflettere su alcuni elementi basilari della scrittura stessa.Border or frontier? Are the two terms synonymous or do they perhaps indicate opposing modes of establishing a dividing line? And what is the relationship between the metaphorical content of the concept of «border», often tied to myth and adventure, and its concrete materialization in frontier, police and military? The author develops these questions from her own particular experience and then extends the survey to another type of border, the cultural and linguistic, and considers literary translation as a form of crossing it and transmitting the basic elements of writing

Equine proliferative enteropathy--a review of recent developments.

Equine proliferative enteropathy (EPE) is a disease of foals caused by the obligate intracellular organism Lawsonia intracellularis. This emerging disease affects mainly weanling foals and causes fever, lethargy, peripheral oedema, diarrhoea, colic and weight loss. The diagnosis of EPE may be challenging and relies on the presence of hypoproteinaemia, thickening of segments of the small intestinal wall observed upon abdominal ultrasonography, positive serology and molecular detection of L. intracellularis in faeces. Although the clinical entity, diagnostic approach and treatment of EPE are well established and described, the epidemiology for this disease has remained largely unaddressed. This article focuses on new developments in the field of EPE, including epidemiology, pathophysiology, clinical signs, diagnosis, treatment and prevention

Frequency of shedding of respiratory pathogens in horses recently imported to the United States.

BackgroundImported horses that have undergone recent long distance transport might represent a serious risk for spreading infectious respiratory pathogens into populations of horses.ObjectiveTo investigate the frequency of shedding of respiratory pathogens in recently imported horses.AnimalsAll imported horses with signed owner consent (n = 167) entering a USDA quarantine for contagious equine metritis from October 2014 to June 2016 were enrolled in the study.MethodsProspective observational study. Enrolled horses had a physical examination performed and nasal secretions collected at the time of entry and subsequently if any horse developed signs of respiratory disease during quarantine. Samples were assayed for equine influenza virus (EIV), equine herpesvirus type-1, -2, -4, and -5 (EHV-1, -2, -4, -5), equine rhinitis virus A (ERAV), and B (ERBV) and Streptococcus equi subspecies equi (S. equi) using quantitative PCR (qPCR).ResultsEquine herpesviruses were detected by qPCR in 52% of the study horses including EHV-2 (28.7%), EHV-5 (40.7%), EHV-1 (1.2%), and EHV-4 (3.0%). Clinical signs were not correlated with being qPCR-positive for EHV-4, EHV-2, or EHV-5. None of the samples were qPCR-positive for EIV, ERAV, ERBV, and S. equi. The qPCR assay failed quality control for RNA viruses in 25% (46/167) of samples.Conclusions and clinical importanceClinical signs of respiratory disease were poorly correlated with qPCR positive status for EHV-2, -4, and -5. The importance of γ-herpesviruses (EHV-2 and 5) in respiratory disease is poorly understood. Equine herpesvirus type-1 or 4 (EHV-1 or EHV-4) were detected in 4.2% of horses, which could have serious consequences if shedding animals entered a population of susceptible horses. Biosecurity measures are important when introducing recently imported horses into resident US populations of horses