Review: The increasing importance of carbon nanotubes and nanostructured conducting polymers in biosensors

The growing need for analytical devices requiring smaller sample volumes, decreased power consumption and improved performance have been driving forces behind the rapid growth in nanomaterials research. Due to their dimensions, nanostructured materials display unique properties not traditionally observed in bulk materials. Characteristics such as increased surface area along with enhanced electrical/optical properties make them suitable for numerous applications such as nanoelectronics, photovoltaics and chemical/biological sensing. In this review we examine the potential that exists to use nanostructured materials for biosensor devices. By incorporating nanomaterials, it is possible to achieve enhanced sensitivity, improved response time and smaller size. Here we report some of the success that has been achieved in this area. Many nanoparticle and nanofibre geometries are particularly relevant, but in this paper we specifically focus on organic nanostructures, reviewing conducting polymer nanostructures and carbon nanotubes

Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe

THE SINGLE-DEGENERATE BINARY ORIGIN OF TYCHO\u27S SUPERNOVA AS TRACED BY THE STRIPPED ENVELOPE OF THE COMPANION

We propose that a nonthermal X-ray arc inside the remnant of Tycho\u27s supernova (SN) represents the interaction between the SN ejecta and the companion star\u27s envelope lost in the impact of the explosion. The X-ray emission of the remnant further shows an apparent shadow casted by the arc in the opposite direction of the explosion site, consistent with the blocking of the SN ejecta by the envelope. This scenario supports the single degenerate binary origin of Tycho\u27s SN. The properties of the X-ray arc, together with the previous detection of the companion candidate and its space velocity by Ruiz-Lapuente et al. and Hernández et al., enable us to further infer that (1) the progenitor binary has a period of 4.9+5.3 –3.0 days, (2) the companion gained a kick velocity of 42 ± 30 km s–1, and (3) the stripped envelope mass is about 0.0016 (≤0.0083) M . However, we note that the nature of the companion candidate is still under debate, and the above parameters need to be revised according to the actual properties of the companion candidate. Further work to measure the proper motion of the arc and to check the capability of the interaction to emit the amount of X-rays observed from the arc is also needed to validate the current scenario

THE SINGLE-DEGENERATE BINARY ORIGIN OF TYCHO'S SUPERNOVA AS TRACED BY THE STRIPPED ENVELOPE OF THE COMPANION

This is the pre-published version harvested from ArXiv. The published version is located at http://iopscience.iop.org/0004-637X/732/1/11We propose that a nonthermal X-ray arc inside the remnant of Tycho's supernova (SN) represents the interaction between the SN ejecta and the companion star's envelope lost in the impact of the explosion. The X-ray emission of the remnant further shows an apparent shadow casted by the arc in the opposite direction of the explosion site, consistent with the blocking of the SN ejecta by the envelope. This scenario supports the single degenerate binary origin of Tycho's SN. The properties of the X-ray arc, together with the previous detection of the companion candidate and its space velocity by Ruiz-Lapuente et al. and Hernández et al., enable us to further infer that (1) the progenitor binary has a period of 4.9+5.3 –3.0 days, (2) the companion gained a kick velocity of 42 ± 30 km s–1, and (3) the stripped envelope mass is about 0.0016 (≤0.0083) M . However, we note that the nature of the companion candidate is still under debate, and the above parameters need to be revised according to the actual properties of the companion candidate. Further work to measure the proper motion of the arc and to check the capability of the interaction to emit the amount of X-rays observed from the arc is also needed to validate the current scenario.1