Particle acceleration in ultra-relativistic oblique shock waves

We perform Monte Carlo simulations of diffusive shock acceleration at highly relativistic oblique shock waves. High upstream flow Lorentz gamma factors are used, which are relevant to models of ultra relativistic particle shock acceleration in Active Galactic Nuclei (AGN) central engines and relativistic jets and Gamma Ray Burst (GRB) fireballs. We investigate numerically the acceleration properties -in the ultra relativistic flow regime of $\Gamma \sim 10-10^{3}$- such as angular distribution, acceleration time constant, particle energy gain versus number of crossings and spectral shapes. We perform calculations for sub-luminal and super-luminal shocks, using two different approaches respectively. The $\Gamma^{2}$ energization for the first crossing cycle and the significantly large energy gain for subsequent crossings as well as the high 'speed up' factors found, are important in supporting the Vietri and Waxman models on GRB ultra-high energy cosmic ray, neutrino, and gamma-ray output.Comment: 24 pages, 35 figures, accepted for publication in Astroparticle Physic

Deficiency in clonogenic endometrial mesenchymal stem cells in obese women with reproductive failure – a pilot study

The mechanisms of obesity associated reproductive complications remain poorly understood. Endometrial mesenchymal stem-cells are critical for cyclic renewal and uterine function. Recently, W5C5+ cells, with high clonogenicity, capable of producing endometrial stroma in vivo, have been described. We sought to investigate the abundance and cloning efficiency of W5C5+ and W5C5− endometrial cells in relation to Body Mass Index, age and reproductive outcome. Design W5C5+ and W5C5− cells were purified from mid-luteal endometrial biopsies (n = 54) by magnetic bead separation and subjected to in vitro colony-forming assays. Results First trimester pregnancy losses were significantly higher in obese subjects (n = 12) compared to overweight (n = 20) and subjects with normal Body Mass Index (n = 22) (P0.05). Conclusions Our observations suggest that the regenerative capacity and plasticity of the endometrium of obese women is suboptimal, which in turn may account for the increased risk of reproductive complications associated with obesity