‘It’s Not Going to be Suburban, It’s Going to be All Urban’: Assembling Post-suburbia in the Toronto and Chicago Regions

Urban and suburban politics are increasingly intertwined in regions that aspire to be global. Powerful actors in the Chicago and Toronto regions have mobilized regional space to brand rescaled images of the urban experience, but questions remain as to who constructs and who can access the benefits of these revised spatial identities. Local political interests have tended to be obfuscated in the regional milieu, most problematically in the spaces between the gentrified inner cities, privileged growth nodes, and the glamorized suburban subdivisions and exurban spaces beyond the city limits. This article analyses how socio-spatial changes in post-suburbanizing urban fringes contribute to the way regions are being reconfigured and reimagined. Guided by current debates at the intersection of assemblage theory and critical urban political economy, our analysis demonstrates how socio-technical infrastructures, policy mobilities and political economic relations are spatially aligned, sustained and dissolved in splintering North American agglomerations. Particular attention is paid to issues of urban transportation and connectivity in uncovering multifaceted modes of suburbanism that now underlie the monistic imagery of the globalized region. Emergent regionalized topologies and territoriality blur conventional understandings of city–suburban dichotomies in extended urban areas that are now characterized by polycentric post-suburban constellations. In terms of their substance and functionality, ‘real existing’ regions are currently re-territorialized as complex assemblages that are embedded in a neoliberalizing political economy whose politics and identities are only beginning to be revealed

Real Existing Regionalism: The Region Between Talk, Territory and Technology

In this essay, we propose the notion of real existing ‘lived’ regionalism as a rejoinder to the normative and ideological debates around new regionalism. Regional forms have shown little convergence in this age of globalized regionalization. Instead of an ideational construct or set of predictable practices, we argue that regionalism is a contested product of discourses (talk), territorial relationships (territory) and technologies (material and of power). The concept of real existing regionalism confronts the tensions between the discursive constructions and normative interventions characterizing much current regionalist debate and the territorial politics and technologies reflecting, generating and directing new state spatial strategic choices. The essay demonstrates the utility of the real existing regionalism framework through an analysis of the greenbelt, transport planning and postsuburbanization in Southern Ontario. We argue that regulatory institutions capture the Toronto region in a mix of rhetorical and technological change that complies with neither preconceived notions of regionalization nor the pessimism of total regional dysfunctionality. Rather, the lived experience of regionalization illuminates the emergent assemblages, multiplicity of everyday flows and ongoing multiscalar negotiations of diverse communities that produce the real existing region

New web-based applications for mechanistic case diagramming

The goal of mechanistic case diagraming (MCD) is to provide students with more in-depth understanding of cause and effect relationships and basic mechanistic pathways in medicine. This will enable them to better explain how observed clinical findings develop from preceding pathogenic and pathophysiological events. The pedagogic function of MCD is in relating risk factors, disease entities and morphology, signs and symptoms, and test and procedure findings in a specific case scenario with etiologic pathogenic and pathophysiological sequences within a flow diagram. In this paper, we describe the addition of automation and predetermined lists to further develop the original concept of MCD as described by Engelberg in 1992 and Guerrero in 2001. We demonstrate that with these modifications, MCD is effective and efficient in small group case-based teaching for second-year medical students (ratings of ~3.4 on a 4.0 scale). There was also a significant correlation with other measures of competency, with a ‘true’ score correlation of 0.54. A traditional calculation of reliability showed promising results (α =0.47) within a low stakes, ungraded environment. Further, we have demonstrated MCD's potential for use in independent learning and TBL. Future studies are needed to evaluate MCD's potential for use in medium stakes assessment or self-paced independent learning and assessment. MCD may be especially relevant in returning students to the application of basic medical science mechanisms in the clinical years

Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1

The treatment of Human African Trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important and pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp. has been identified as a candidate target and it has been shown previously that substituted pyrrolo[2,3-d]pyrimidines are inhibitors of PTR1 from T. brucei (J. Med. Chem. 2010, 53, 221-229). In this study, 61 new pyrrolo[2,3-d]pyrimidines have been prepared, designed with input from new crystal structures of 23 of these compounds complexed with PTR1, and evaluated in screens for enzyme inhibitory activity against PTR1 and in vitro antitrypanosomal activity. 8 compounds were sufficiently active in both screens to take forward to in vivo evaluation. Thus although evidence for trypanocidal activity in a stage I disease model in mice was obtained, the compounds were too toxic to mice for further development

Bridging ‘Infrastructural Solutions’ and ‘Infrastructures as Solution’: Regional Promises and Urban Pragmatism

The potential of infrastructure ‘as a solution’ is currently at the forefront of American political consciousness. Historic levels of investment in infrastructure proffer seismic material, economic, and symbolic transformations at a near-continental scale. However, the present policy context for infrastructure planning in the US is confounded by a mosaic of decision-making authorities that hamper the development of cohesive approaches to sustainable and equitable development. This situation underscores the need to identify how infrastructural futures are assembled and scaled as simultaneously continuous and emergent, old and new, and marked by the diverse capacities of various stakeholders. This paper makes a case for ‘seeing like a region’ when examining transformative approaches to infrastructural change, as infrastructure systems regularly transcend the boundaries of urban space and hence become enmeshed in the goals of broader constituencies and interests. Through a case study of the Southwestern Pennsylvania Commission, we question how infrastructural futures are understood and materialised by the region’s central planning stakeholders. Our analysis pays particular attention to the challenges faced by regional planning organisations when navigating the spatial–temporal frames of incremental and radical change. As the Southwestern Pennsylvania Commission operates with limited staff capacity, high regulatory burdens, and short time horizons for budgeting processes, incremental changes to infrastructure often are the best hope for solving regional challenges of structural inequality and uneven access to resources. This demonstrates how the solutions proffered by infrastructural development are confounded by the dynamics that come into focus when evaluated from the regional scale. Yet we also identify possibilities for regional approaches that foster equitable urban futures within the spatial envelopes created by infrastructural systems and imaginaries that transition from reactive ‘infrastructural solutions’ to a proactive materialisation of ‘infrastructures as solutions’

The use of oral recombinant feline interferon omega in two cats with type II diabetes mellitus and concurrent feline chronic gingivostomatitis syndrome

Articles in International JournalsFeline Chronic Gingivostomatitis Syndrome (FCGS) is a common disease in clinical practice. Among the therapeutic options available, long-acting corticosteroids are frequently used due to their anti-inflammatory and immunosuppressive properties. Although they may improve the clinical symptoms, they can lead to a progressive form of the disease that becomes refractory to treatment. Furthermore, their direct relationship with type II diabetes mellitus (DM) is well known. Consequently, these drugs are controversial and not recommended for routine management of FCGS. Recombinant feline interferon-omega (rFeIFN-ω) is an immunomodulatory compound. Recently, its daily oral administration has been shown to be successful in treating refractory cases of FCGS. This case study describes two clinical cases of type II DM complicated by FCGS. Both animals were calicivirus positive and they had been previously treated with long-acting corticosteroids, which may have been the major cause of DM. The two cats were treated with glargine insulin (Lantus, starting dose 1 IU/cat twice daily (BID)), achieving remission 10 and 18 weeks later respectively. Considering the difficulty with control of FCGS in these animals, an oral daily dose of rFeIFN-ω was started as an alternative to long-acting corticosteroids. In both cats oral clinical signs gradually improved and 60 days after the start of therapy the owners reported a significant relief of pain during mastication. According to the authors’ knowledge, this is the first case report that describes the successful use of rFeIFN-ω in the management of FCGS in type II diabetic cats, in which long-acting corticosteroids are contraindicated

Regionalizing the Infrastructure Turn: A Research Agenda

An interdisciplinary ‘infrastructure turn’ has emerged over the past 20 years that disputes the concept of urban infrastructure as a staid or neutral set of physical artefacts. Responding to the increased conceptual, geographical and political importance of infrastructure – and endemic issues of access, expertise and governance that the varied provision of infrastructures can cause – this intervention asserts the significance of applying a regional perspective to the infrastructure turn. This paper forwards a critical research agenda for the study of ‘infrastructural regionalisms’ to interrogate: (1) how we study and produce knowledge about infrastructure; (2) how infrastructure is governed across or constrained by jurisdictional boundaries; (3) who drives the construction of regional infrastructural imaginaries; and (4) how individuals and communities differentially experience regional space through infrastructure. Analysing regions through infrastructure provides a novel perspective on the regional question and consequently offers a framework to understand better the implications of the current infrastructure moment for regional spaces worldwide

Boys' and girls' clubs

"Club work is based on sound principles and has come to stay. It is supported by federal and state aid as a definite form of agricultural extension work. Boys and girls on the farm are aided in their work and every possible advantage is extended to flt them, for better living and "to improve country life." It is proper in this connection to mention that club work has received special recognition from the State Superintendent of Public Instruction. On Pages 124-126 of the last Annual School Report will be found a general statement of this movement. On Pages 122 and 124 of the last State Course of Study will b.e found the . details of some of the projects. In the first county campaign which had as an aim to acquaint patrons, pupils and teachers with the nature and purpose of Boys' and Girls' Clubs, the state superintendent took personal part and gave sanction to the work. So far as known no other state has given stronger recognition to club work than Missouri."--Page 3