Elicitation and representation of expert knowledge for computer aided diagnosis in mammography

To study how professional radiologists describe, interpret and make decisions about micro-calcifications in mammograms. The purpose was to develop a model of the radiologists' decision making for use in CADMIUM II, a computerized aid for mammogram interpretation that combines symbolic reasoning with image processing

Direct Detection of the Tertiary Component in the Massive Multiple HD 150 136 with VLTI

Massive stars are of fundamental importance for almost all aspects of astrophysics, but there still exist large gaps in our understanding of their properties and formation because they are rare and therefore distant. It has been found that most O-stars are multiples. HD 150 136 is the nearest system to Earth with >100 M_sol, and provides a unique opportunity to study an extremely massive system. Recently, evidence for the existence of a third component in HD 150 136, in addition to the tight spectroscopic binary that forms the main component, was found in spectroscopic observations. Our aim was to image and obtain astrometric and photometric measurements of this component using long baseline optical interferometry to further constrain the nature of this component. We observed HD150136 with the near-infrared instrument AMBER attached to the ESO VLT Interferometer. The recovered closure phases are robust to systematic errors and provide unique information on the source asymmetry. Therefore, they are of crucial relevance for both image reconstruction and model fitting of the source structure. The third component in HD 150 136 is clearly detected in the high-quality data from AMBER. It is located at a projected angular distance of 7.3 mas, or about 13 AU at the line-of-sight distance of HD 150 136, at a position angle of 209 degrees East of North, and has a flux ratio of 0.25 with respect to the inner binary. We resolved the third component of HD 150 136 in J, H and K filters. The luminosity and color of the tertiary agrees with the predictions and shows that it is also an O main-sequence star. The small measured angular separation indicates that the tertiary may be approaching the periastron of its orbit. These results, only achievable with long baseline near infrared interferometry, constitute the first step towards the understanding of the massive star formation mechanisms

Use of computer-aided detection (CAD) tools in screening mammography: a multidisciplinary investigation

We summarise a set of analyses and studies conducted to assess the effects of the use of a computer-aided detection (CAD) tool in breast screening. We have used an interdisciplinary approach that combines: (a) statistical analyses inspired by reliability modelling in engineering; (b) experimental studies of decisions of mammography experts using the tool, interpreted in the light of human factors psychology; and (c) ethnographic observations of the use of the tool both in trial conditions and in everyday screening practice. Our investigations have shown patterns of human behaviour and effects of computer-based advice that would not have been revealed by a standard clinical trial approach. For example, we found that the negligible measured effect of CAD could be explained by a range of effects on experts' decisions, beneficial in some cases and detrimental in others. There is some evidence of the latter effects being due to the experts using the computer tool differently from the intentions of the developers. We integrate insights from the different pieces of evidence and highlight their implications for the design, evaluation and deployment of this sort of computer tool

Why Are People's Decisions Sometimes Worse with Computer Support?

In many applications of computerised decision support, a recognised source of undesired outcomes is operators' apparent over-reliance on automation. For instance, an operator may fail to react to a potentially dangerous situation because a computer fails to generate an alarm. However, the very use of terms like "over-reliance" betrays possible misunderstandings of these phenomena and their causes, which may lead to ineffective corrective action (e.g. training or procedures that do not counteract all the causes of the apparently "over-reliant" behaviour). We review relevant literature in the area of "automation bias" and describe the diverse mechanisms that may be involved in human errors when using computer support. We discuss these mechanisms, with reference to errors of omission when using "alerting systems", with the help of examples of novel counterintuitive findings we obtained from a case study in a health care application, as well as other examples from the literature

Unveiling the near-infrared structure of the massive-young stellar object NGC 3603 IRS 9A with sparse aperture masking and spectroastrometry

Contemporary theory holds that massive stars gather mass during their initial phases via accreting disk-like structures. However, conclusive evidence for disks has remained elusive for the most massive young objects. This is mainly due to significant observational challenges. Incisive studies, even targeting individual objects, are therefore relevant to the progression of the field. NGC 3603 IRS 9A* is a young massive stellar object still surrounded by an envelope of molecular gas. Previous mid-infrared observations with long-baseline interferometry provided evidence for a disk of 50 mas diameter at its core. This work aims at a comprehensive study of the physics and morphology of IRS 9A at near-infrared wavelengths. New sparse aperture masking interferometry data taken with NACO/VLT at Ks and Lp filters were obtained and analysed together with archival CRIRES spectra of the H2 and BrG lines. The calibrated visibilities recorded at Ks and Lp bands suggest the presence of a partially resolved compact object of 30 mas at the core of IRS 9A, together with the presence of over-resolved flux. The spectroastrometric signal of the H2 line shows that this spectral feature proceeds from the large scale extended emission (300 mas) of IRS 9A, while the BrG line appears to be formed at the core of the object (20 mas). This scenario is consistent with the brightness distribution of the source for near- and mid-infrared wavelengths at various spatial scales. However, our model suffers from remaining inconsistencies between SED modelling and the interferometric data. Moreover, the BrG spectroastrometric signal indicates that the core of IRS 9A exhibits some form of complexity such as asymmetries in the disk. Future high-resolution observations are required to confirm the disk/envelope model and to flesh out the details of the physical form of the inner regions of IRS 9A.Comment: Accepted to be published in Astronomy & Astrophysics, 13 pages, 14 figure

On the Enhanced Interstellar Scattering Toward B1849+005

(Abridged) This paper reports new Very Large Array (VLA) and Very Long Baseline Array (VLBA) observations of the extragalactic source B1849+005 at frequencies between 0.33 and 15 GHz and the re-analysis of archival VLA observations at 0.33, 1.5, and 4.9 GHz. The structure of this source is complex but interstellar scattering dominates the structure of the central component at least to 15 GHz. An analysis of the phase structure functions of the interferometric visibilities shows the density fluctuations along this line of sight to be anisotropic (axial ratio = 1.3) with a frequency-independent position angle, and having an inner scale of roughly a few hundred kilometers. The anisotropies occur on length scales of order 10^{15} cm (D/5 kpc), which within the context of certain magnetohydrodynamic turbulence theories indicates the length scale on which the kinetic and magnetic energy densities are comparable. A conservative upper limit on the velocity of the scattering material is 1800 km/s. In the 0.33 GHz field of view, there are a number of other sources that might also be heavily scattered. Both B1849+005 and PSR B1849+00 are highly scattered, and they are separated by only 13'. If the lines of sight are affected by the same ``clump'' of scattering material, it must be at least 2.3 kpc distant. However, a detailed attempt to account for the scattering observables toward these sources does not produce a self-consistent set of parameters for such a clump. A clump of H\alpha emission, possibly associated with the H II region G33.418-0.004, lies between these two lines of sight, but it seems unable to account for all of the required excess scattering.Comment: 23 pages, LaTeX2e AASTeX, 13 figures in 14 PostScript files, accepted for publication in Ap

CAD in mammography: lesion-level versus case-level analysis of the effects of prompts on human decisions

Object: To understand decision processes in CAD-supported breast screening by analysing how prompts affect readers’ judgements of individual mammographic features (lesions). To this end we analysed hitherto unexamined details of reports completed by mammogram readers in an earlier evaluation of a CAD tool. Material and methods: Assessments of lesions were extracted from 5,839 reports for 59 cancer cases. Statistical analyses of these data focused on what features readers considered when recalling a cancer case and how readers reacted to CAD prompts. Results: About 13.5% of recall decisions were found to be caused by responses to features other than those indicating actual cancer. Effects of CAD: lesions were more likely to be examined if prompted; the presence of a prompt on a cancer increased the probability of both detection and recall especially for less accurate readers in subtler cases; lack of prompts made cancer features less likely to be detected; false prompts made non-cancer features more likely to be classified as cancer. Conclusion: The apparent lack of impact reported for CAD in some studies is plausibly due to CAD systematically affecting readers’ identification of individual features, in a beneficial way for certain combinations of readers and features and a damaging way for others. Mammogram readers do not ignore prompts. Methodologically, assessing CAD by numbers of recalled cancer cases may be misleading

Properties of bow-shock sources at the Galactic center

There are an enigmatic population of massive stars around the Galactic Center (GC) that were formed some Ma ago. A fraction of these stars has been found to orbit the supermassive black hole, SgrA*, in a projected clockwise disk, which suggests that they were formed in a formerly existing dense disk around SgrA*. We focus on the extended, near-infrared (NIR) sources IRS1W, IRS5, IRS10W, and IRS21 that have been suggested to be young, massive stars that form bow-shocks through their interaction with the ISM. Their nature has impeded accurate determination of their orbital parameters. We aim at establishing their nature and kinematics to test whether they form part of the clockwise disk. We performed NIR multi-wavelength imaging using adaptive optics (AO) and sparse aperture masking (SAM). We introduce a new method for self-calibration of the SAM PSF in dense stellar fields. The emission mechanism, morphology and kinematics of the targets were examined via 3D bow-shock models. We confirm previous findings that IRS21, IRS1W, and IRS5 are bow-shocks created by the interaction between mass-losing stars and the interstellar gas. The nature of IRS10W remains unclear. Our modeling shows that the bow-shock-emission is caused by thermal emission while the scattering of stellar light does not play any significant role. IRS 1W appears to be a bow-shock produced by an anisotropic stellar wind or by locally inhomogeneous ISM density. Our best-fit models provide an estimate of the local proper motion of the ISM in the NA in agreement with the published models. Assuming that all of the sources are tied to SgrA*, their orbital planes were obtained via a Monte-Carlo simulation. Our orbital analysis suggests that they are not part of any of the clockwise disk. We thus add more evidence to recent findings that a large part of the massive stars show apparently random orbital orientations.Comment: accepted for publication by A&A, 17 pages, 11 figures, 1 appendi

Sub-milliarcsecond Imaging of Quasars and AGN

We have used the VLBA at 15 GHz to image the structure of 132 strong compact AGN and quasars with a resolution better than one milliarcsecond and a dynamic range typically exceeding 1000 to 1. These observations were made as part of a program to investigate the sub-parsec structure of quasars and AGN and to study the changes in their structure with time. Many of the sources included in our study, particularly those located south of +35 degrees, have not been previously imaged with milliarcsecond resolution. Each of the sources has been observed at multiple epochs. In this paper we show images of each of the 132 sources which we have observed. For each source we present data at the epoch which had the best quality data. The milliarcsecond jets generally appear one-sided but two-sided structure is often found in lower luminosity radio galaxies and in high luminosity quasars with gigahertz peaked spectra. Usually the structure is unresolved along the direction perpendicular to the jet, but a few sources have broad plumes. In some low luminosity radio galaxies, the structure appears more symmetric at 2 cm than at long wavelengths. The apparent long wavelength symmetry in these sources is probably due to absorption by intervening material. A few sources contain only a single component with any secondary feature at least a thousand times weaker. We find no obvious correlation of radio morphology and the detection of gamma-ray emission by EGRET.Comment: 19 pages, 3 tables, 3 figures. Figure 2 (132 contour diagrams) is long and is omitted here. Figure 2 may be viewed at http://www.cv.nrao.edu/2cmsurvey/ In press, Astronomical Journal, April 199