How much is too much? Lowering the legal drink-drive limit

The current legal limit on drivers’ blood alcohol content was set at 80mg/100ml nearly 40 years ago and there are now only 3 other Member States of the European Union, all of them small countries, with limits higher than 50mg/100ml. Deaths from drink driving in Great Britain stopped falling 10 years ago, and show signs of rising. The reasons for the setting of the current limit in 1967 and changes since then are discussed, and a fresh look is taken at the likely annual reduction in deaths on the road in Great Britain if the limit here were lowered to 50mg/100ml. Lowering the limit is seen not as a measure to be taken in isolation, but as part of a substantial initiative to resume and sustain a clear downward trend in death and injury resulting from the avoidable excess risk of driving after drinking

Video vehicle detection at signalised junctions: a simulation-based study

Many existing advanced methods of traffic signal control depend on information about approaching traffic provided by inductive loop detectors at particular points in the road. But analysis of images from CCTV cameras can in principle provide more comprehensive information about traffic approaching and passing through junctions, and cameras may be easier to install and maintain than loop detectors, and some systems based on video detection have already been in use for some time. Against this background, computer simulation has been used to explore the potential of existing and immediately foreseeable capability in automatic on-line image analysis to extract information relevant to signal control from images provided by cameras mounted in acceptable positions at signal-controlled junctions. Some consequences of extracting relevant information in different ways were investigated in the context of an existing detailed simulation model of vehicular traffic moving through junctions under traffic-responsive signal control, and the development of one basic and one advanced algorithm for traffic-responsive control. The work was confined as a first step to operation of one very simple signalcontrolled junction. Two techniques for extraction of information from images were modelled - a more ambitious technique based on distinguishing most of the individual vehicles visible to the camera, and a more modest technique requiring only that the presence of vehicles in any part of the image be distinguished from the background scene. In the latter case, statistical modelling was used to estimate the number of vehicles corresponding to any single area of the image that represents vehicles rather than background. At the simple modelled junction, each technique of extraction enabled each of the algorithms for traffic-responsive control of the signals to achieve average delays per vehicle appreciably lower than those given by System D control, and possibly competitive with those that MOVA would give, but comparison with MOVA was beyond the scope of the initial study. These results of simulation indicate that image analysis of CCTV pictures should be able to provide sufficient information in practice for traffic-responsive control that is competitive with existing techniques. Ways in which the work could be taken further were discussed with practitioners, but have not yet been progressed

A validated BEM model to analyse hydrodynamic loading on tidal stream turbines blades

This is the author accepted manuscript. The final version is available from the link in this record.AWTEC 2016: 3rd Asian Wave and Tidal Energy Conference, 24-28 October 2016, SingaporeThis paper details a Blade Element Momentum (BEM) model for a 3 bladed, horizontal axis Tidal Stream Turbine (TST). The code capabilities are tested and validated by applying a range of different turbine parameters and operating conditions, where results are compared to numerous datasets. The model shows excellent agreement to performance and thrust measurements for 3 of the 4 datasets. Compared to other BEM models improved correlations are seen at higher rotational speeds. The fourth case shows over predictions of up to 30% in power at peak operating speed. In this case, CFD studies show better correlation due to the ability to capture detailed flow features around the blade as well as free surface effects, however require 3 to 4 orders of magnitude greater computational cost. Steady, non-uniform inflow functionality is incorporated into the model, where distributions of thrust and torque along the blade as well as cyclic loads are determined. These show the potential of the model to be used in combination with tools such as stress and fatigue analyses to improve the blade design process.This research is carried out as part of the Industrial Doctoral Centre for Offshore Renewable Energy (IDCORE) programme, funded by the Energy Technology partnership and the RCUK Energy programme (Grant number EP/J500847/1), in collaboration with EDF R&D

Idylls of socialism : the Sarajevo Documentary School and the problem of the Bosnian sub-proletariat

This historical overview of the Sarajevo Documentary School considers the films, in the light of their recent re-emergence, as indicative of both the legacy of socialist realism (even in the context of Yugoslav media) and attempted social engineering in the Bosnia of the 1960s and 1970s. The argument is made that the documentaries, despite their questionable aesthetic status (in respect of cinma-vrit and ethnography) and problematic ideological strategies and attempted interventions, document a history and offer insights that counter the prevailing revisionist trends in the presentation of Eastern and Central European history

Advancing safe system: The need for realistic goals

Safe System is an approach to road safety management that can be advocated as being the current state of the art; it draws comprehensively upon experience of recent decades in road safety management in many countries. Inspired by Vision Zero, the Safe System Sourcebook purports to eliminate death and life-changing injury from use of the roads. This paper questions whether the elimination of death and life changing injuries is at odds with reality. It calls for an adapted vision with realistically ambitious goals: one of zero preventable deaths and life-changing injuries. Realistic goals are important for road safety in the realm of day-to-day political reality. Emphasis on realistic goals rather than remote prospects should not only help to advance Safe System but also help to align progress towards it with the promotion of active travel and the creation of places for living and walking in our cities

Designed glycopeptidomimetics disrupt protein−protein interactions mediating amyloid β‑peptide aggregation and restore neuroblastoma cell viability

How anti-Alzheimer’s drug candidates that reduce amyloid 1−42 peptide fibrillization interact with the most neurotoxic species is far from being understood. We report herein the capacity of sugar-based peptidomimetics to inhibit both Aβ1−42 early oligomerization and fibrillization. A wide range of bio- and physicochemical techniques, such as a new capillary electrophoresis method, nuclear magnetic resonance, and surface plasmon resonance, were used to identify how these new molecules can delay the aggregation of Aβ1−42. We demonstrate that these molecules interact with soluble oligomers in order to maintain the presence of nontoxic monomers and to prevent fibrillization. These compounds totally suppress the toxicity of Aβ1−42 toward SH-SY5Y neuroblastoma cells, even at substoichiometric concentrations. Furthermore, demonstration that the best molecule combines hydrophobic moieties, hydrogen bond donors and acceptors, ammonium groups, and a hydrophilic β-sheet breaker element provides valuable insight for the future structure-based design of inhibitors of Aβ1−42 aggregation

Clinical trials of medicinal cannabis for appetite-related symptoms from advanced cancer: a survey of preferences, attitudes and beliefs among patients willing to consider participation

© 2016 Royal Australasian College of Physicians Background: Australian clinical trials are planned to evaluate medicinal cannabis in a range of clinical contexts. Aims: To explore the preferences, attitudes and beliefs of patients eligible and willing to consider participation in a clinical trial of medicinal cannabis for poor appetite and appetite-related symptoms from advanced cancer. Methods: A cross-sectional anonymous survey was administered from July to December 2015 online and in eight adult outpatient palliative care and/or cancer services. Respondents were eligible if they were ≥18 years, had advanced cancer and poor appetite/taste problems/weight loss and might consider participating in a medicinal cannabis trial. Survey items focused on medicinal rather than recreational cannabis use and did not specify botanical or pharmaceutical products. Items asked about previous medicinal cannabis use and preferences for delivery route and invited comments and concerns. Results: There were 204 survey respondents, of whom 26 (13%) reported prior medicinal cannabis use. Tablets/capsules were the preferred delivery mode (n = 144, 71%), followed by mouth spray (n = 84, 42%) and vaporiser (n = 83, 41%). Explanations for preferences (n = 134) most commonly cited convenience (n = 66; 49%). A total of 82% (n = 168) of respondents indicated that they had no trial-related concerns, but a small number volunteered concerns about adverse effects (n = 14) or wanted more information/advice (n = 8). Six respondents volunteered a belief that cannabis might cure cancer, while two wanted assurance of efficacy before participating in a trial. Conclusion: Justification of modes other than tablets/capsules and variable understanding about cannabis and trials will need addressing in trial-related information to optimise recruitment and ensure that consent is properly informed

Characteristics of individuals presenting to treatment for primary alcohol problems versus other drug problems in the Australian patient pathways study

Background: People seeking treatment for substance use disorders often have additional health and social issues. Although individuals presenting with alcohol as the primary drug of concern (PDOC) account for nearly half of all treatment episodes to the Australian alcohol and other drug (AOD) service system, previous treatment cohort studies have focused only on the profile of Australian heroin or methamphetamine users. While studies overseas indicate that clients seeking treatment primarily for their drinking are less likely to experience social and economic marginalisation than those seeking treatment primarily for illicit or pharmaceutical drug use, very little research has directly compared individuals presenting with alcohol as the PDOC to those primarily presenting with other drugs as their PDOC. Methods: Seven hundred and ninety-six participants were recruited at entry to specialist AOD treatment in Victoria and Western Australia, and completed measures of demographic and social factors, substance use, quality of life, service use, and criminal justice involvement. We compared those with alcohol as their PDOC to those with other drugs as their PDOC using Pearson chi-square and Mann–Whitney U tests. Results: Rates of social disadvantage, poor quality of life, high severity of substance dependence, and past-year AOD, mental health, acute health, and social service use were high in all groups. However, participants with alcohol as the PDOC were older; more likely to have an educational qualification; less likely to report criminal justice involvement, housing/homelessness service use, tobacco smoking, or problems with multiple substances; and reported better environmental quality of life; but were more likely to have used ambulance services, than those with other drugs as their PDOC. Conclusions: While those seeking treatment primarily for alcohol problems appear less likely to suffer some forms of social and economic disadvantage or to use multiple substances than those with a primary drug problem, they experience similarly high levels of substance dependence severity and mental health and AOD service use. These findings reinforce the need for AOD services to integrate or coordinate care with programs that address the many complexities clients frequently present with, while also acknowledging differences between those seeking treatment for alcohol versus other drug problems