Corrigendum: NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.

Nature Communications 7 Article number: 11724 doi: 10.1038/ncomms11724(2016); Published: 25 May 2016; Updated: 2 August 2016. The affiliation details for Amiya K. Patra are incomplete in this Article. The correct affiliations are given below: Institute of Translational and Stratified Medicine, Peninsula Schools of Medicine and Dentistry, University of Plymouth, Plymouth Science Park, Research Way, Plymouth PL6 8BU, UK

Hepatic alterations are accompanied by changes to bile acid transporter-expressing neurons in the hypothalamus after traumatic brain injury

Annually, there are over 2 million incidents of traumatic brain injury (TBI) and treatment options are non-existent. While many TBI studies have focused on the brain, peripheral contributions involving the digestive and immune systems are emerging as factors involved in the various symptomology associated with TBI. We hypothesized that TBI would alter hepatic function, including bile acid system machinery in the liver and brain. The results show activation of the hepatic acute phase response by 2 hours after TBI, hepatic inflammation by 6 hours after TBI and a decrease in hepatic transcription factors, Gli 1, Gli 2, Gli 3 at 2 and 24 hrs after TBI. Bile acid receptors and transporters were decreased as early as 2 hrs after TBI until at least 24 hrs after TBI. Quantification of bile acid transporter, ASBT-expressing neurons in the hypothalamus, revealed a significant decrease following TBI. These results are the first to show such changes following a TBI, and are compatible with previous studies of the bile acid system in stroke models. The data support the emerging idea of a systemic influence to neurological disorders and point to the need for future studies to better define specific mechanisms of action

An Evaluation of the Effects of the Potato Starch on the Biogas Produced from the Anaerobic Digestion of Potato Wastes

Anaerobic digestion (AD) has undergone many developments since its first appearance. Despite that, there are still some environmental and economical obstacles that are limiting its sustainability. On the other hand, different types of starch have proven their effectiveness in some different applications. Food processing industries are considered one of the largest generators of waste in the environment. With an aid of the response surface methodology (RSM), the proposed study aimed to find an optimised way to overcome the obstacles by studying the impacts of the starch isolated from the potato peels on the biogas produced from the AD of potato peels before and after starch separation. The study found that potato peels represented approximately 12.5% of the potato total weight. The starch has only a slight influence on the quantity of the biogas produced and much lower influences on its quality. This finding suggests further investigation is required on the production of starch bio-based products simultaneously with the biogas and bio-slurry, which may mitigate environmental influences and economical obstacles of AD and make it more commercially attractive. The study showed also that the highest energy gain by the g-VS/0.2 L of potato peels was 62.9% at 35 °C, 1.62 g-VS/0.2 L organic concentration and 50% sludge concentration, which yielded a maximum CH4 of 72.4%

Enhancing the Economic Viability of Anaerobic Digestion by Exploiting the Whole Biomass of Mango Waste and Its Residues after Digestion

A significant expansion of anaerobic digestion (AD) processes would certainly result in a reduction in the current dependence on fossil fuels. The operational costs, the large amounts of digestate generated and the expenses of dealing with it and the volatility of the fuel indexes represent major environmental and economical challenges to the diffusion of AD. Increasing the bio-products of AD could possibly help in increasing its profitability and limit these challenges. This study investigates the influence of mango starch and seed coats on the biogas produced from mango waste. To overcome the environmental challenges, the digestate was tested and its bio-fertiliser potential proven. The study reached the conclusion that the effect of the starch on the AD biogas of mango waste is low while the effect of the seed coats is quite high. This finding supports further investigations to evaluate the effect of the production of mango starch and seed coat-based products on the profitability of AD. The highest energy balance achieved was 65% at 32 °C, 3.93 g-VS organic concentration and 37% sludge concentration, which yielded a maximum CH4 yield of 62.5%. This finding encourages the application of gate fees for accepting bio-waste, which may help in overcoming its economic challenges.</jats:p

Enhancing the Economic Viability of Anaerobic Digestion by Exploiting the Whole Biomass of Mango Waste and Its Residues after Digestion

A significant expansion of anaerobic digestion (AD) processes would certainly result in a reduction in the current dependence on fossil fuels. The operational costs, the large amounts of digestate generated and the expenses of dealing with it and the volatility of the fuel indexes represent major environmental and economical challenges to the diffusion of AD. Increasing the bio-products of AD could possibly help in increasing its profitability and limit these challenges. This study investigates the influence of mango starch and seed coats on the biogas produced from mango waste. To overcome the environmental challenges, the digestate was tested and its bio-fertiliser potential proven. The study reached the conclusion that the effect of the starch on the AD biogas of mango waste is low while the effect of the seed coats is quite high. This finding supports further investigations to evaluate the effect of the production of mango starch and seed coat-based products on the profitability of AD. The highest energy balance achieved was 65% at 32 &deg;C, 3.93 g-VS organic concentration and 37% sludge concentration, which yielded a maximum CH4 yield of 62.5%. This finding encourages the application of gate fees for accepting bio-waste, which may help in overcoming its economic challenges

An Evaluation of the Effects of the Potato Starch on the Biogas Produced from the Anaerobic Digestion of Potato Wastes

Anaerobic digestion (AD) has undergone many developments since its first appearance. Despite that, there are still some environmental and economical obstacles that are limiting its sustainability. On the other hand, different types of starch have proven their effectiveness in some different applications. Food processing industries are considered one of the largest generators of waste in the environment. With an aid of the response surface methodology (RSM), the proposed study aimed to find an optimised way to overcome the obstacles by studying the impacts of the starch isolated from the potato peels on the biogas produced from the AD of potato peels before and after starch separation. The study found that potato peels represented approximately 12.5% of the potato total weight. The starch has only a slight influence on the quantity of the biogas produced and much lower influences on its quality. This finding suggests further investigation is required on the production of starch bio-based products simultaneously with the biogas and bio-slurry, which may mitigate environmental influences and economical obstacles of AD and make it more commercially attractive. The study showed also that the highest energy gain by the g-VS/0.2 L of potato peels was 62.9% at 35 °C, 1.62 g-VS/0.2 L organic concentration and 50% sludge concentration, which yielded a maximum CH4 of 72.4%.</jats:p