A two-step MaxLik-MaxEnt strategy to infer photon distribution from on/off measurement at low quantum efficiency

A method based on Maximum-Entropy (ME) principle to infer photon distribution from on/off measurements performed with few and low values of quantum efficiency is addressed. The method consists of two steps: at first some moments of the photon distribution are retrieved from on/off statistics using Maximum-Likelihood estimation, then ME principle is applied to infer the quantum state and, in turn, the photon distribution. Results from simulated experiments on coherent and number states are presented.Comment: 4 figures, to appear in EPJ

Informationally complete measurements and groups representation

Informationally complete measurements on a quantum system allow to estimate the expectation value of any arbitrary operator by just averaging functions of the experimental outcomes. We show that such kind of measurements can be achieved through positive-operator valued measures (POVM's) related to unitary irreducible representations of a group on the Hilbert space of the system. With the help of frame theory we provide a constructive way to evaluate the data-processing function for arbitrary operators.Comment: 9 pages, no figures, IOP style. Some new references adde

Approaching the Heisenberg limit with two mode squeezed states

Two mode squeezed states can be used to achieve Heisenberg limit scaling in interferometry: a phase shift of $\delta \phi \approx 2.76 /$ can be resolved. The proposed scheme relies on balanced homodyne detection and can be implemented with current technology. The most important experimental imperfections are studied and their impact quantified.Comment: 4 pages, 7 figure

Economic evaluation of sublingual immunotherapy vs. symptomatic treatment in allergic asthma

The worldwide increased prevalence of allergic diseases, and especially of respiratory allergy, is paralleled by increased health costs. This requires consideration of the cost to efficacy ratio of the available treatment to identify the optimal choice

Quantum reconstruction of an intense polarization squeezed optical state

We perform a reconstruction of the polarization sector of the density matrix of an intense polarization squeezed beam starting from a complete set of Stokes measurements. By using an appropriate quasidistribution, we map this onto the Poincare space providing a full quantum mechanical characterization of the measured polarization state.Comment: 4 pages, 4 eps color figure

Dopamine D 4 Receptor-Deficient Mice Display Cortical Hyperexcitability

The dopamine D(4) receptor (D(4)R) is predominantly expressed in the frontal cortex (FC), a brain region that receives dense input from midbrain dopamine (DA) neurons and is associated with cognitive and emotional processes. However, the physiological significance of this dopamine receptor subtype has been difficult to explore because of the slow development of D(4)R agonists and antagonists the selectivity and efficacy of which have been rigorously demonstrated in vivo. We have attempted to overcome this limitation by taking a multidimensional approach to the characterization of mice completely deficient in this receptor subtype. Electrophysiological current and voltage-clamp recordings were performed in cortical pyramidal neurons from wild-type and D(4)R-deficient mice. The frequency of spontaneous synaptic activity and the frequency and duration of paroxysmal discharges induced by epileptogenic agents were increased in mutant mice. Enhanced synaptic activity was also observed in brain slices of wild-type mice incubated in the presence of the selective D(4)R antagonist PNU-101387G. Consistent with greater electrophysiological activity, nerve terminal glutamate density associated with asymmetrical synaptic contacts within layer VI of the motor cortex was reduced in mutant neurons. Taken together, these results suggest that the D(4)R can function as an inhibitory modulator of glutamate activity in the FC.Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Cepeda, Carlos. University of California at Los Angeles; Estados UnidosFil: Hurst, Raymond S.. University of California at Los Angeles; Estados UnidosFil: Flores Hernandez, Jorge. University of California at Los Angeles; Estados UnidosFil: Ariano, Marjorie A.. The Chicago Medical School; Estados UnidosFil: Falzone, Tomas Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Kozell, Laura B.. Oregon Health Sciences University; Estados UnidosFil: Meshul, Charles K.. Oregon Health Sciences University; Estados UnidosFil: Bunzow, James R.. Oregon Health Sciences University; Estados UnidosFil: Low, Malcolm J.. Oregon Health Sciences University; Estados UnidosFil: Levine, Michael S.. University of California at Los Angeles; Estados UnidosFil: Grandy, David K.. Oregon Health Sciences University; Estados Unido

Iterative algorithm for reconstruction of entangled states

An iterative algorithm for the reconstruction of an unknown quantum state from the results of incompatible measurements is proposed. It consists of Expectation-Maximization step followed by a unitary transformation of the eigenbasis of the density matrix. The procedure has been applied to the reconstruction of the entangled pair of photons.Comment: 4 pages, no figures, some formulations changed, a minor mistake correcte

Iterative maximum-likelihood reconstruction in quantum homodyne tomography

I propose an iterative expectation maximization algorithm for reconstructing a quantum optical ensemble from a set of balanced homodyne measurements performed on an optical state. The algorithm applies directly to the acquired data, bypassing the intermediate step of calculating marginal distributions. The advantages of the new method are made manifest by comparing it with the traditional inverse Radon transformation technique

Altered Neurocircuitry in the Dopamine Transporter Knockout Mouse Brain

The plasma membrane transporters for the monoamine neurotransmitters dopamine, serotonin, and norepinephrine modulate the dynamics of these monoamine neurotransmitters. Thus, activity of these transporters has significant consequences for monoamine activity throughout the brain and for a number of neurological and psychiatric disorders. Gene knockout (KO) mice that reduce or eliminate expression of each of these monoamine transporters have provided a wealth of new information about the function of these proteins at molecular, physiological and behavioral levels. In the present work we use the unique properties of magnetic resonance imaging (MRI) to probe the effects of altered dopaminergic dynamics on meso-scale neuronal circuitry and overall brain morphology, since changes at these levels of organization might help to account for some of the extensive pharmacological and behavioral differences observed in dopamine transporter (DAT) KO mice. Despite the smaller size of these animals, voxel-wise statistical comparison of high resolution structural MR images indicated little morphological change as a consequence of DAT KO. Likewise, proton magnetic resonance spectra recorded in the striatum indicated no significant changes in detectable metabolite concentrations between DAT KO and wild-type (WT) mice. In contrast, alterations in the circuitry from the prefrontal cortex to the mesocortical limbic system, an important brain component intimately tied to function of mesolimbic/mesocortical dopamine reward pathways, were revealed by manganese-enhanced MRI (MEMRI). Analysis of co-registered MEMRI images taken over the 26 hours after introduction of Mn^(2+) into the prefrontal cortex indicated that DAT KO mice have a truncated Mn^(2+) distribution within this circuitry with little accumulation beyond the thalamus or contralateral to the injection site. By contrast, WT littermates exhibit Mn^(2+) transport into more posterior midbrain nuclei and contralateral mesolimbic structures at 26 hr post-injection. Thus, DAT KO mice appear, at this level of anatomic resolution, to have preserved cortico-striatal-thalamic connectivity but diminished robustness of reward-modulating circuitry distal to the thalamus. This is in contradistinction to the state of this circuitry in serotonin transporter KO mice where we observed more robust connectivity in more posterior brain regions using methods identical to those employed here

Binary optical communication in single-mode and entangled quantum noisy channels

We address binary optical communication in single-mode and entangled quantum noisy channels. For single-mode we present a systematic comparison between direct photodetection and homodyne detection in realistic conditions, i.e. taking into account the noise that occurs both during the propagation and the detection of the signals. We then consider entangled channels based on twin-beam state of radiation, and show that with realistic heterodyne detection the error probability at fixed channel energy is reduced in comparison to the single-mode cases for a large range of values of quantum efficiency and noise parameters