Population genetics of abnormal haemoglobins in Burkina Faso, West Africa

Les fréquences géniques des hémoglobines A (HbA), HbS et HbC, ont été étudiées au Burkina-Faso (BF) ainsi que dans une région avoisinante du Niger : Ayorou. La fréquence d'HbS est plus élevée dans le Sahel (Nord du BF et Ayorou) que dans la zone de savane. L'inverse est trouvé pour HbC. Les résultats essentiels de ce travail sont : (a) la confirmation d'un pic de la fréquence génique de HbC dans le centre du BF (plateau Mossi); (b) une corrélation négative entre les fréquences de HbS et HbC. Cavalli-Sforza et Bodmer ont observé que cette corrélation atteint une intensité significativement différente de celle qui est attendue, par suite de la relation allélique entre HbS et HbC; (c) la comparaison de ces résultats avec les données rassemblées par Livingstone montre une modification de la valeur sélective des différents génotypes au cours des dernières années. Les individus AS ont une valeur sélective plus basse et les AA et SS en ont une plus haute. Nos données sont favorables à l'hypothèse du relâchement partiel de la sélection dans cette région. (Résumé d'auteur

Alternaria species associated with early blight epidemics on tomato and other Solanaceae crops in northwestern Algeria

Early blight is a common disease of Solanaceae crops worldwide. The occurrence of Alternaria spp. was studied during three epidemics on tomato in northwestern Algeria. Alternaria was detected in more than 80 % of the diseased plant samples and accounted for more than 50 % of the total fungal isolates recovered from these samples. Morphological and molecular investigations revealed that small-spored isolates producing beaked conidia, i.e. belonging to the section alternaria, were prominent in most of the surveyed locations representing more than 80 % of the total Alternaria isolates in three locations (Mascara, Ain Témouchent and Sidi Belabbèsse). Based on their sporulation patterns they were recognized as A. alternata and A. tenuissima. Small-spored isolates producing conidia without beak and assigned to A. consortialis were also found at a low frequency (< 1 %). Large-spored isolates producing conidia ended by typical long beaks and identified as A. linariae (syn. A. tomatophila), A. solani and A. grandis were also recovered from all the sampled areas and represented 33.8 %, 6.3 % and 1.3 % of the total Alternaria isolates, respectively. Pathogenicity tests on tomato with a selection of 85 strains representative of the isolates collection revealed that all the tested isolates were able to produce extending lesions on inoculated leaves albeit with variable intensity. Large-spored species included the most aggressive isolates. Small-spored Alternaria, although less aggressive than large-spored Alternaria, had the ability to provoke brown necrotic spots and circumstantially developed synergistic interactions in mixed infections with moderately aggressive isolates of A. linariae

Negotiating the inhuman: Bakhtin, materiality and the instrumentalization of climate change

The article argues that the work of literary theorist Mikhail M. Bakhtin presents a starting point for thinking about the instrumentalization of climate change. Bakhtin’s conceptualization of human–world relationships, encapsulated in the concept of ‘cosmic terror’, places a strong focus on our perception of the ‘inhuman’. Suggesting a link between the perceived alienness and instability of the world and in the exploitation of the resulting fear of change by political and religious forces, Bakhtin asserts that the latter can only be resisted if our desire for a false stability in the world is overcome. The key to this overcoming of fear, for him, lies in recognizing and confronting the worldly relations of the human body. This consciousness represents the beginning of one’s ‘deautomatization’ from following established patterns of reactions to predicted or real changes. In the vein of several theorists and artists of his time who explored similar ‘deautomatization’ strategies – examples include Shklovsky’s ‘ostranenie’, Brecht’s ‘Verfremdung’, Artaud’s emotional ‘cruelty’ and Bataille’s ‘base materialism’ – Bakhtin proposes a more playful and widely accessible experimentation to deconstruct our ‘habitual picture of the world’. Experimentation is envisioned to take place across the material and the textual to increase possibilities for action. Through engaging with Bakhtin’s ideas, this article seeks to draw attention to relations between the imagination of the world and political agency, and the need to include these relations in our own experiments with creating climate change awareness

The Saffman-Taylor problem on a sphere

The Saffman-Taylor problem addresses the morphological instability of an interface separating two immiscible, viscous fluids when they move in a narrow gap between two flat parallel plates (Hele-Shaw cell). In this work, we extend the classic Saffman-Taylor situation, by considering the flow between two curved, closely spaced, concentric spheres (spherical Hele-Shaw cell). We derive the mode-coupling differential equation for the interface perturbation amplitudes and study both linear and nonlinear flow regimes. The effect of the spherical cell (positive) spatial curvature on the shape of the interfacial patterns is investigated. We show that stability properties of the fluid-fluid interface are sensitive to the curvature of the surface. In particular, it is found that positive spatial curvature inhibits finger tip-splitting. Hele-Shaw flow on weakly negative, curved surfaces is briefly discussed.Comment: 26 pages, 4 figures, RevTex, accepted for publication in Phys. Rev.

Coldness and Cruelty as Performance in Deleuze's Proust

This book is an encounter between Deleuze the philosopher, Proust the novelist, and Beckett the writer creating interdisciplinary and inter-aesthetic bridges between them, covering textual, visual, sonic and performative phenomena, ..

A flavoprotein supports cell wall properties in the necrotrophic fungus Alternaria brassicicola

Background Flavin-dependent monooxygenases are involved in key biological processes as they catalyze a wide variety of chemo-, regio- and enantioselective oxygenation reactions. Flavoprotein monooxygenases are frequently encountered in micro-organisms, most of which require further functional and biocatalytic assessment. Here we investigated the function of the AbMak1 gene, which encodes a group A flavin monooxygenase in the plant pathogenic fungus Alternaria brassicicola, by generating a deficient mutant and examining its phenotype. Results Functional analysis indicates that the AbMak1 protein is involved in cell wall biogenesis and influences the melanization process. We documented a significant decrease in melanin content in the Δabmak1 strain compared to the wild-type and complemented strains. We investigated the cell wall morphology and physical properties in the wild-type and transformants using electron and atomic force microscopy. These approaches confirmed the aberrant morphology of the conidial wall structure in the Δabmak1 strain which had an impact on hydrophilic adhesion and conidial surface stiffness. However, there was no significant impairment in growth, conidia formation, pathogenicity or susceptibility to various environmental stresses in the Δabmak1 strain. Conclusion This study sheds new light on the function of a fungal flavin-dependent monooxygenase, which plays an important role in melanization

Getting nowhere fast: a teleological conception of socio-technical acceleration

It has been frequently recognized that the perceived acceleration of life that has been experienced from the Industrial Revolution onward is engendered, at least in part, by an understanding of speed as an end in itself. There is no equilibrium to be reached – no perfect speed – and as such, social processes are increasingly driven not by rational ends, but by an indeterminate demand for acceleration that both defines and restricts the decisional possibilities of actors. In Aristotelian terms, this is a final cause – i.e. a teleology – of speed: it is not a defined end-point, but rather, a purposive aim that predicates the emergence of possibilities. By tracing this notion of telos from its beginnings in ancient Greece, through the ur-empiricism of Francis Bacon, and then to our present epoch, this paper seeks to tentatively examine the way in which such a teleology can be theoretically divorced from the idea of historical progress, arguing that the former is premised upon an untenable ontological privileging of becoming

p.Ala541Thr variant of MEN1 gene: A non deleterious polymorphism or a pathogenic mutation?

Context Multiple Endocrine Neoplasia Type 1 (MEN1) is an autosomal dominant inherited syndrome, related to mutations in the MEN1 gene. Controversial data suggest that the nonsynonymous p.Ala541Thr variant, usually considered as a non-pathogenic polymorphism, may be associated with an increased risk of MEN1-related lesions in carriers. Objective The aim of this study was to evaluate the pathogenic influence of the p.Ala541Thr variant on clinical and functional outcomes. Patients and methods We analysed a series of 55 index patients carrying the p.Ala541Thr variant. Their clinical profile was compared to that of 117 MEN1 patients. The biological impact of the p.Ala541Thr variant on cell growth was additionally investigated on menin-deficient Leydig cell tumour (LCT)10 cells generated from Men1+/Men1− heterozygous knock-out mice, and compared with wild type (WT). Results The mean age at first appearance of endocrine lesions was similar in both p.Ala541Thr carriers and MEN1 patients, but no p.Ala541Thr patient had more than one cardinal MEN1 lesion at initial diagnosis. A second MEN1 lesion was diagnosed in 13% of MEN1 patients and in 7% of p.Ala541Thr carriers in the year following preliminary diagnosis. Functional studies on LCT10 cells showed that overexpression of the p.Ala541Thr variant did not inhibit cell growth, which is in direct contrast to results obtained from investigation of WT menin protein. Conclusion Taken together, these data raise the question of a potential pathogenicity of the p.Ala541Thr missense variant of menin that commonly occurs within the general population. Additional studies are required to investigate whether it may be involved in a low-penetrance MEN1 phenotype