Carpenter, Reuben Part 2. David Taylor interviews Reuben Carpenter regarding boatbuilding.

Part 2 of David Taylor's November 24, 1983 interview with Reuben Carpenter regarding boatbuilding. Mr. Carpenter discusses the methods and materials used in boatbuilding, types of boats, pricing boats, and the cost of boatbuilding

Abstract P1-01-02: The SentiMag study: Sentinel node biopsy with superparamagnetic iron oxide vs. radioisotope

Abstract Background: The SentiMag study compares the “gold standard” 99mTc with a new technique, which employs superparamagnetic iron oxide particles (SPIO) for localization of sentinel lymph nodes. Aim of this study is to investigate the potential equivalency of the SentiMag® technique in comparison to the gold standard of sentinel lymph node biopsy (SLNB). Materials and methods: In a prospective, multicentre and multinational 2-arm study, 150 patients with histologically verified breast carcinoma are examined. For comparison, SLNs are marked initially with radioisotope following a 1- or 2-day protocol. Additionally, SPIO (Sienna+®) is injected in the operation room by the surgeon at least 20 minutes before SLNB into the subareolar interstitial tissue, followed by 5 minutes massage. SLN-detection is carried out using a magnetometer (SentiMag®) and a gamma probe. Preparation and excision of lymph nodes is conducted using both techniques in a parallel manner. All lymph nodes marked with either tracer are excised. Results: Interim analysis of 138 patients resulted in a detection rate concordance per patient of 97% (134/138). An average of 1.9 (radioisotope) and 2.0 (SPIO) lymph nodes were collected per patient. Nodal detection rate was 92% (250/273) for the radioisotope vs. 97% (265/273) for the SPIO tracer with magnetometer detection. The proportion of pathologically positive lymph nodes was 38/250 (15%) vs. 39/265 (15%) for the radioisotope and the SPIO tracer respectively. All pathologically positive lymph nodes detected with the conventional technique (radioisotope) were also detected with the new technique (SentiMag®). Conclusions: The SentiMag® provides an easy technique which can be rapidly implemented into daily routine. Due to the simple handling, preoperative efforts can be reduced to a minimum. If further and consistent results prove its efficacy, this technique may ultimately replace the standard of care. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P1-01-02.</jats:p

Different glasses to look into the three Cs: Component, connector, coordination

Component, connector, and coordination have been key concepts exploited in different communities to manage the complexity of concurrent and distributed system development. In this paper, we discuss three approaches within three different classes: composition in software architectures, coordination models, and programming abstractions for concurrency. These classes encompass different perspectives and solutions to face crucial challenges in developing concurrent and distributed systems. The approaches are discussed with respect to some characteristics of interest for the above classes: compositionality, incrementality, scalability, compositional reasoning, reusability, and evolution