Patterns of CT lung injury and toxicity after stereotactic radiotherapy delivered with helical tomotherapy in early stage medically inoperable NSCLC

To evaluate toxicity and patterns of radiologic lung injury on CT images after hypofractionated image-guided stereotactic body radiotherapy (SBRT) delivered with helical tomotherapy (HT) in medically early stage inoperable non-small-cell lung cancer (NSCLC)

Immune factors preceding diagnosis of glioma: a Prostate Lung Colorectal Ovarian Cancer Screening Trial nested case-control study.

BackgroundEpidemiological studies of adult glioma have identified genetic and environmental risk factors, but much remains unclear. The aim of the current study was to evaluate anthropometric, disease-related, and prediagnostic immune-related factors for relationship with glioma risk.MethodsWe conducted a nested case-control study among the intervention arm of the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial. One hundred and twenty-four glioma cases were identified and each matched to four controls. Baseline characteristics were collected at enrollment and were evaluated for association with glioma status. Serum specimens were collected at yearly intervals and were analyzed for immune-related factors including TGF-β1, TNF-α, total IgE, and allergen-specific IgE. Immune factors were evaluated at baseline in a multivariate conditional logistic regression model, along with one additional model that incorporated the latest available measurement.ResultsA family history of glioma among first-degree relatives was associated with increased glioma risk (OR = 4.41, P = .002). In multivariate modeling of immune factors at baseline, increased respiratory allergen-specific IgE was inversely associated with glioma risk (OR for allergen-specific IgE > 0.35 PAU/L: 0.59, P = .03). A logistic regression model that incorporated the latest available measurements found a similar association for allergen-specific IgE (P = .005) and showed that elevated TGF-β1 was associated with increased glioma risk (P-value for trend <.0001).ConclusionThe results from this prospective prediagnostic study suggest that several immune-related factors are associated with glioma risk. The association observed for TGF-β1 when sampling closer to the time of diagnosis may reflect the nascent brain tumor's feedback on immune function

Screening of Nuclear Reactions in the Sun and Solar Neutrinos

We quantitatively determine the effect and the uncertainty on solar neutrino production arising from the screening process. We present predictions for the solar neutrino fluxes and signals obtained with different screening models available in the literature and by using our stellar evolution code. We explain these numerical results in terms of simple laws relating the screening factors with the neutrino fluxes. Futhermore we explore a wider range of models for screening, obtained from the Mitler model by introducing and varying two phenomenological parameters, taking into account effects not included in the Mitler prescription. Screening implies, with respect to a no-screening case, a central temperat reduction of 0.5%, a 2% (8%) increase of Beryllium (Boron)-neutrino flux and a 2% (12%) increase of the Gallium (Chlorine) signal. We also find that uncertainties due to the screening effect ar at the level of 1% for the predicted Beryllium-neutrino flux and Gallium signal, not exceeding 3% for the Boron-neutrino flux and the Chlorine signal.Comment: postscript file 11 pages + 4 figures compressed and uuencoded we have replaced the previous paper with a uuencoded file (the text is the same) for any problem please write to [email protected]

On the realization of Symmetries in Quantum Mechanics

The aim of this paper is to give a simple, geometric proof of Wigner's theorem on the realization of symmetries in quantum mechanics that clarifies its relation to projective geometry. Although several proofs exist already, it seems that the relevance of Wigner's theorem is not fully appreciated in general. It is Wigner's theorem which allows the use of linear realizations of symmetries and therefore guarantees that, in the end, quantum theory stays a linear theory. In the present paper, we take a strictly geometrical point of view in order to prove this theorem. It becomes apparent that Wigner's theorem is nothing else but a corollary of the fundamental theorem of projective geometry. In this sense, the proof presented here is simple, transparent and therefore accessible even to elementary treatments in quantum mechanics.Comment: 8 page

Electron screening in molecular fusion reactions

Recent laboratory experiments have measured fusion cross sections at center-of-mass energies low enough for the effects of atomic and molecular electrons to be important. To extract the cross section for bare nuclei from these data (as required for astrophysical applications), it is necessary to understand these screening effects. We study electron screening effects in the low-energy collisions of Z=1 nuclei with hydrogen molecules. Our model is based on a dynamical evolution of the electron wavefunctions within the TDHF scheme, while the motion of the nuclei is treated classically. We find that at the currently accessible energies the screening effects depend strongly on the molecular orientation. The screening is found to be larger for molecular targets than for atomic targets, due to the reflection symmetry in the latter. The results agree fairly well with data measured for deuteron collisions on molecular deuterium and tritium targets.Comment: 15 Page RevTeX document, twelve postscript figures, now in a uufile packag

Muonic hydrogen cascade time and lifetime of the short-lived 2S2S state

Metastable ${2S}$ muonic-hydrogen atoms undergo collisional ${2S}$-quenching, with rates which depend strongly on whether the $\mu p$ kinetic energy is above or below the ${2S}\to {2P}$ energy threshold. Above threshold, collisional ${2S} \to {2P}$ excitation followed by fast radiative ${2P} \to {1S}$ deexcitation is allowed. The corresponding short-lived $\mu p ({2S})$ component was measured at 0.6 hPa $\mathrm{H}_2$ room temperature gas pressure, with lifetime $\tau_{2S}^\mathrm{short} = 165 ^{+38}_{-29}$ ns (i.e., $\lambda_{2S}^\mathrm{quench} = 7.9 ^{+1.8}_{-1.6} \times 10^{12} \mathrm{s}^{-1}$ at liquid-hydrogen density) and population $\epsilon_{2S}^\mathrm{short} = 1.70^{+0.80}_{-0.56}$ % (per $\mu p$ atom). In addition, a value of the $\mu p$ cascade time, $T_\mathrm{cas}^{\mu p} = (37\pm5)$ ns, was found.Comment: 4 pages, 3 figure

Fusion rate enhancement due to energy spread of colliding nuclei

Experimental results for sub-barrier nuclear fusion reactions show cross section enhancements with respect to bare nuclei which are generally larger than those expected according to electron screening calculations. We point out that energy spread of target or projectile nuclei is a mechanism which generally provides fusion enhancement. We present a general formula for calculating the enhancement factor and we provide quantitative estimate for effects due to thermal motion, vibrations inside atomic, molecular or crystal system, and due to finite beam energy width. All these effects are marginal at the energies which are presently measurable, however they have to be considered in future experiments at still lower energies. This study allows to exclude several effects as possible explanation of the observed anomalous fusion enhancements, which remain a mistery.Comment: 17 pages with 3 ps figure included. Revtex styl

Atomic effects in astrophysical nuclear reactions

Two models are presented for the description of the electron screening effects that appear in laboratory nuclear reactions at astrophysical energies. The two-electron screening energy of the first model agrees very well with the recent LUNA experimental result for the break-up reaction $He3(He3,2p)He^{4}$, which so far defies all available theoretical models. Moreover, multi-electron effects that enhance laboratory reactions of the CNO cycle and other advanced nuclear burning stages, are also studied by means of the Thomas-Fermi model, deriving analytical formulae that establish a lower and upper limit for the associated screening energy. The results of the second model, which show a very satisfactory compatibility with the adiabatic approximation ones, are expected to be particularly useful in future experiments for a more accurate determination of the CNO astrophysical factors.Comment: 14 RevTex pages + 2 ps (revised) figures. Phys.Rev.C (in production

Holomorphic linearization of commuting germs of holomorphic maps

Let $f_1, ..., f_h$ be $h\ge 2$ germs of biholomorphisms of \C^n fixing the origin. We investigate the shape a (formal) simultaneous linearization of the given germs can have, and we prove that if $f_1, ..., f_h$ commute and their linear parts are almost simultaneously Jordanizable then they are simultaneously formally linearizable. We next introduce a simultaneous Brjuno-type condition and prove that, in case the linear terms of the germs are diagonalizable, if the germs commutes and our Brjuno-type condition holds, then they are holomorphically simultaneously linerizable. This answers to a multi-dimensional version of a problem raised by Moser.Comment: 24 pages; final version with erratum (My original paper failed to cite the work of L. Stolovitch [ArXiv:math/0506052v2]); J. Geom. Anal. 201