Electronic control/display interface technology

An effort to produce a representative workstation for the Space Station Data Management Test Bed that provides man/machine interface design options for consolidating, automating, and integrating the space station work station, and hardware/software technology demonstrations of space station applications is discussed. The workstation will emphasize the technologies of advanced graphics engines, advanced display/control medias, image management techniques, multifunction controls, and video disk utilizations

Late Palaeozoic lithostratigraphy of the Andean Precordillera revisited (San Juan Province, Argentina)

New data on some neopalaeozoic lithostratigraphic units of the central sector of the Argentinean Precordillera are presented. The western Precordillera displays occasional outcrops of siliciclastic rocks of the Late Palaeozoic. These rocks are separated by two main unconformi­ties related to the development of the Chanic (Upper Devonian-early Carboniferous) and Gondwanan (late Carboniferous-early Permian) orogens. A major unconformity marks the beginning of the Andean cycle in middle Permian times. The Del Ratón Formation (800 m) in the studied area is made up of conglomerates and can be divided into two units. The basal part (Lower Member) was deposited in a fjord environment. The Upper Member was generated by an alluvial system that was mainly dominated by upper flow-regime plane beds, whereas its uppermost part accumulated in a fan delta setting. The clast provenance and the main palaeocurrents suggest the existence of a significant topographic high to the W and NW of the present outcrops. The El Planchón Formation (1400 m) is mainly composed of shales and sandstones as a result of sedimentation in a deep-sea fan environment. These lutite-dominated materials graded laterally north­wards into conglomerates in a glacial setting. The Del Ratón and El Planchón formations of the Lower Carboniferous correspond to the synorogenic Chanic sedimentation (Chanic foreland basin). Thereafter, the stratigraphic succession underwent deformation which led to its prolonged subaerial exposure and rubefaction. In Permian times, a marine transgression gave rise to the Del Salto Formation (600 m), which is constituted by beach deposits with some aeolian reworking and which lies unconformably over the Lower Carboniferous rocks. Conglomerates (Quebrada del Alumbre Formation, 100 m) produced by an alluvial system prograded episodically into coastal areas. The Escombrera Formation (350 m) is composed of beach deposits prograding seawards. This formation probably represents the end of the Palaeozoic sedimentary record. Thereafter, a playa-lake and an alluvial fan system were generated (Quebrada de la Arena Formation). This unit (750 m) was the last infill of the Gondwanan retroarc foreland, the total thickness of which was about 4000 m.Se presentan nuevos datos sobre las unidades neopaleozoicas aflorantes en la parte occidental de la Precordillera andina. Esas unidades litoestratigráficas estan separadas por dos discordancias angulares principales asociadas al desarrollo de las orogenias Chánica (Devónico tardío-Carbonífero temprano) y Gondwánica (Carbonífero tardío-Pérmico temprano) respectivamente. Otra nueva discordancia sugiere el inicio del ciclo andino durante el Pérmico medio. La Formación Del Ratón (800 m) está constituida principalmente por conglomerados y puede dividirse en dos unidades de rango menor: la parte basal y la parte superior respectivamente. La parte basal (Miembro inferior) fue acumulada en un fiordo. La parte superior (Miembro superior) fue generada en un sistema alluvial dominado predominantemente por la acumulación de capas planas de alto régimen de flujo, mientras que la parte más alta fue depositada en un entorno de abanico deltaico (fandelta). La procedencia de los clastos y las paleocorrientes principales indican la presencia de un relieve topográfico alto y significativo, situado al O y NO de los afloramientos actuales.La Formación El Planchón (1400 m) constituida principalmente por lutitas y areniscas fue acumulada en un contexto de abanico submarino (deep-sea fan). Estos materiales predominantemente lutíticos pasan lateralmente hacia el norte a conglomerados acumulados en un ambiente sedimentario glacial. Las Formaciones Del Ratón y El Planchón corresponden a la sedimentación sinorogénica Chánica (cuenca de antepaís chánica). Posteriormente, la sucesión estratigráfica sufrió una deformación que dió lugar a una prolongada exposición subaérea y su consiguiente rubefacción. Durante el Pérmico, una transgresión marina produjo la acumulación de la Formación Del Salto (600 m), que está constituída por depósitos de playa con algún retrabajamiento eólico y que recubre discordantemente los materiales del Carbonífero inferior. Un sistema aluvial conglomerático (Formación Quebrada del Alumbre 100 m) pogradó episódicamente sobre las zonas costeras. La Formación Escombrera (350 m), que está constituída por materiales arenosos coste-ros progradantes hacia el mar, representa, muy probablemente, el final del registro sedimentario paleozoico en esta zona. Posteriormente se generó otra discordancia sobre la que se acumularon materiales arenosos en un contexto de cursos fluviales trenzados sobre los que se disponen materiales lutíticos acumulados en una ciénaga (playa-lake) que gradan, primero a cursos trenzados, luego a cursos sinousos y finalmente a abanicos aluviales (Formación Quebrada de la Arena). Esta unidad (750 m) corresponde al último relleno sedimentario de la cuenca Gondwánica de retroarco, cuya potencia es del orden de unos 4000 m.Fil: Colombo, F.. Universidad de Barcelona; EspañaFil: Limarino, Carlos Oscar. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Geología; ArgentinaFil: Spalletti, Luis Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Geológicas. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Investigaciones Geológicas; ArgentinaFil: Busquets, P. Universidad de Barcelona; EspañaFil: Cardo, R.. Secretaría de Industria y Minería. Servicio Geológico Minero Argentino; ArgentinaFil: Mendez Bedia, I. Universidad de Oviedo; EspañaFil: Heredia, N.. Instituto Geológico y Minero de España; Españ

Anàlisi de la concentració sèrica de vitamina D com a factor de risc de càncer de pròstata i agressivitat tumoral

Alguns estudis observacionals han suggerit que el dèficit de vitamina D podria relacionar-se amb un major risc de càncer de pròstata i amb una major incidència en àrees geogràfiques de menor insolació. L'objectiu d'aquest estudi ha sigut relacionar els nivells sèrics de vitamina D i parathormona amb el risc de càncer de pròstata i amb la agressivitat tumora

The signal-to-noise analysis of the Little-Hopfield model revisited

Using the generating functional analysis an exact recursion relation is derived for the time evolution of the effective local field of the fully connected Little-Hopfield model. It is shown that, by leaving out the feedback correlations arising from earlier times in this effective dynamics, one precisely finds the recursion relations usually employed in the signal-to-noise approach. The consequences of this approximation as well as the physics behind it are discussed. In particular, it is pointed out why it is hard to notice the effects, especially for model parameters corresponding to retrieval. Numerical simulations confirm these findings. The signal-to-noise analysis is then extended to include all correlations, making it a full theory for dynamics at the level of the generating functional analysis. The results are applied to the frequently employed extremely diluted (a)symmetric architectures and to sequence processing networks.Comment: 26 pages, 3 figure

On metastable configurations of small-world networks

We calculate the number of metastable configurations of Ising small-world networks which are constructed upon superimposing sparse Poisson random graphs onto a one-dimensional chain. Our solution is based on replicated transfer-matrix techniques. We examine the denegeracy of the ground state and we find a jump in the entropy of metastable configurations exactly at the crossover between the small-world and the Poisson random graph structures. We also examine the difference in entropy between metastable and all possible configurations, for both ferromagnetic and bond-disordered long-range couplings.Comment: 9 pages, 4 eps figure

Cognitive impairment induced by delta9-tetrahydrocannabinol occurs through heteromers between cannabinoid CB1 and serotonin 5-HT2A receptors

Delta-9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, induces numerous undesirable effects, including memory impairments, anxiety, and dependence. Conversely, THC also has potentially therapeutic effects, including analgesia, muscle relaxation, and neuroprotection. However, the mechanisms that dissociate these responses are still not known. Using mice lacking the serotonin receptor 5-HT2A, we revealed that the analgesic and amnesic effects of THC are independent of each other: while amnesia induced by THC disappears in the mutant mice, THC can still promote analgesia in these animals. In subsequent molecular studies, we showed that in specific brain regions involved in memory formation, the receptors for THC and the 5-HT2A receptors work together by physically interacting with each other. Experimentally interfering with this interaction prevented the memory deficits induced by THC, but not its analgesic properties. Our results highlight a novel mechanism by which the beneficial analgesic properties of THC can be dissociated from its cognitive side effects

An associative network with spatially organized connectivity

We investigate the properties of an autoassociative network of threshold-linear units whose synaptic connectivity is spatially structured and asymmetric. Since the methods of equilibrium statistical mechanics cannot be applied to such a network due to the lack of a Hamiltonian, we approach the problem through a signal-to-noise analysis, that we adapt to spatially organized networks. The conditions are analyzed for the appearance of stable, spatially non-uniform profiles of activity with large overlaps with one of the stored patterns. It is also shown, with simulations and analytic results, that the storage capacity does not decrease much when the connectivity of the network becomes short range. In addition, the method used here enables us to calculate exactly the storage capacity of a randomly connected network with arbitrary degree of dilution.Comment: 27 pages, 6 figures; Accepted for publication in JSTA

A novel high-throughput analytical method to quantify microplastics in water by flow cytometry

Microplastics (MPs) are pervasive contaminants with unclear toxicological impacts. Current research on MP pollution relies on low-throughput methodologies, which are time-consuming and cannot directly measure MP concentration in suspensions. This study presents a qualitative and quantitative flow cytometry-based method for analysing MPs in water, offering a faster and more sustainable alternative. The method involves density separation to remove interfering particles, UV irradiation to eliminate microorganisms, and filtration to remove particles above 100 µm. The sensitivity of the method for different types of MPs, such as polystyrene (PS), polypropylene (PP), polyvinyl chloride (PVC), polyethylene terephthalate (PET), and polyamide (PA) microbeads, ranges from 2 µg/L to 1 mg/L. For these MPs, good linearity was found in matrix-matched calibration where the most concentrated standard was 5 mg/L (R2 0.9820–0.9989) although the linear range can be larger (e.g. 42 mg MP/L for PS microbeads). The repeatability and reproducibility of the method for the model PS MP were <17.0% and 8.5%, respectively. The sample treatment method consisting of density separation and UV pretreatment, when carried out independently, led to 95.0% and 93.4% recoveries. The overall trueness of the optimized method for various sizes and compositions of microbeads is about 97%, according to validation supported by microscopy analysis. This method can substitute the traditional quantitative analytical approach based on counting microbeads with microscopy