Automated patient monitoring system

Radio-linked patient monitoring system collects several channels of physiological data from as many as 64 hospital patients and transmits the data in digital form to a central control station. The system consists of a central control station and battery-operated patient units comprising small strap-on electronics packages

Fine Scale Features of Turbulent Shear Flows

This thesis presents an investigation into kinematic features of fine scale turbulence in free shear flows. In particular it seeks to examine the interaction between the different length scales present in shear flow turbulence as well as the interaction between the strain-rate tensor and the rotation tensor, which are the symmetric and skew-symmetric components of the velocity gradient tensor respectively. A new multi-scale particle image velocimetry (PIV) technique is developed that is capable of resolving the flow at two different dynamic ranges, centred on inertial range scales and on dissipative range scales, simultaneously. This data is used to examine the interaction between large-scale fluctuations, of the order of the integral scale, and inertial and dissipative range fluctuations. The large-scale fluctuations are observed to have an amplitude and frequency modulation effect on the small scales, and the small scales are shown to have a slight effect on the large scales, illustrating the two way nature of the energy cascade. A mechanism whereby integral scale rollers leave behind a wake of intense small-scale fluctuations is proposed. The interaction between strain and rotation is examined with regards to the rate of enstrophy amplification (ωiSijωj). It is found that the mechanism that is responsible for the nature of enstrophy amplification is the alignment tendency between the extensive strain-rate eigenvector and the vorticity vector. This mechanism is also observed to be scale dependent for ωiSijωj > 0, but independent for ωiSijωj < 0. This is subsequently confirmed with new dual-plane stereoscopic PIV experiments performed as part of this study. Finally, computational data is used to examine the effect of experimental noise and variation of spatial resolution on the observation and understanding of this strain - rotation interaction

How do they do it? Understanding back office efficiency savings made by English councils

Purpose – The purpose of this paper is to illustrate the back office efficiency savings made by English councils during the 2004 Spending Review (SR04) period in order to consider the relationship between service delivery, audit and inspection and, efficiency programmes in local government. It considers three research questions: the use of secondary data, the relationship between efficiency savings and contextual factors, and the influence of audit and inspection in delivering efficient public services. Design/methodology/approach – Through statistical analysis the paper discusses the secondary analysis of publicly available sets of administrative data about local councils in England. These datasets are the annual efficiency statements (AES) taken from records made by each council. The paper discusses through the analysis of the AES the degree of efficiency savings and service improvements in English councils and whether efficiency savings are influenced by internal or external contextual factors. Findings – The paper illustrates that secondary data is a useful source of data, but finds that although councils have achieved the efficiency savings set there is no relationship with the contextual factors. The paper considers the influence of audit and inspection, suggesting that the focus has been on meeting the target rather than local needs. Originality/value – This paper aims to contribute to the debate regarding the use of performance indicators, audit and inspection and efficiency achievement within local government. The paper starts to explore the implication in the UK where, after a decade of use, the influence of these is reducing dramatically

Terror management theory and politeness : the effects of mortality salience on preferences for proper linguistic etiquette

Terror management theorists propose that people experience death anxiety when reminded of their death and defend against it by engaging in symbolic psychological defenses through cultural identification. Language is an integral component of culture and the human experience. A study was conducted to examine the effects of mortality salience on people’s evaluations of the cultural norm of linguistic politeness. It was hypothesized that participants who had their mortality made salient would downgrade impoliteness and show more favor toward politeness when evaluating requests and persons and rating their likelihood of compliance with the requests in comparison to control participants. The data did not support the hypotheses. Study limitations, theoretical considerations, and future avenues for research are discussed.Department of Psychological ScienceThesis (M.A.

An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice

Forkhead-associated (FHA) domains are modular phosphopeptide recognition motifs with a striking preference for phosphothreonine-containing epitopes. FHA domains have been best characterized in eukaryotic signaling pathways but have been identified in six proteins in Mycobacterium tuberculosis, the causative organism of tuberculosis. One of these, coded by gene Rv1747, is an ABC transporter and the only one to contain two such modules. A deletion mutant of Rv1747 is attenuated in a mouse intravenous injection model of tuberculosis where the bacterial load of the mutant is 10-fold lower than that of the wild type in both lungs and spleen. In addition, growth of the mutant in mouse bone marrow-derived macrophages and dendritic cells is significantly impaired. In contrast, growth of this mutant in vitro was indistinguishable from that of the wild type. The mutant phenotype was lost when the mutation was complemented by the wild-type allele, confirming that it was due to mutation of Rv1747. Using yeast two-hybrid analysis, we have shown that the Rv1747 protein interacts with the serine-threonine protein kinase PknF. This interaction appears to be phospho-dependent since it is abrogated in a kinase-dead mutant and by mutations in the presumed activation loop of PknF and in the first FHA domain of Rv1747. These results demonstrate that the protein coded by Rv1747 is required for normal virulent infection by M. tuberculosis in mice and, since it interacts with a serine-threonine protein kinase in a kinase-dependent manner, indicate that it forms part of an important phospho-dependent signaling pathway

Facets and Typed Relations as Tools for Reasoning Processes in Information Retrieval

Faceted arrangement of entities and typed relations for representing different associations between the entities are established tools in knowledge representation. In this paper, a proposal is being discussed combining both tools to draw inferences along relational paths. This approach may yield new benefit for information retrieval processes, especially when modeled for heterogeneous environments in the Semantic Web. Faceted arrangement can be used as a se-lection tool for the semantic knowledge modeled within the knowledge repre-sentation. Typed relations between the entities of different facets can be used as restrictions for selecting them across the facets

Anderson impurity in pseudo-gap Fermi systems

We use the numerical renormalization group method to study an Anderson impurity in a conduction band with the density of states varying as rho(omega) \propto |omega|^r with r>0. We find two different fixed points: a local-moment fixed point with the impurity effectively decoupled from the band and a strong-coupling fixed point with a partially screened impurity spin. The specific heat and the spin-susceptibility show powerlaw behaviour with different exponents in strong-coupling and local-moment regime. We also calculate the impurity spectral function which diverges (vanishes) with |omega|^{-r} (|\omega|^r) in the strong-coupling (local moment) regime.Comment: 8 pages, LaTeX, 4 figures includes as eps-file

The status of continuous improvement in ICiPS members in 2015

This report was commissioned following discussions in 2014, between the authors of this report and staff members from ICiPS about the paucity of relevant research about the current status of continuous (CI) in the UK. The purpose of this report is therefore, to examine the status of CI in ICiPS members in 2015, with a view to helping ICiPS serve the needs of its members, and also to provide an agenda for research organisations such as the Centre for Service Management (CSM) at Loughborough University. This report covers seven case studies and draws out common themes. In this report, CI is understood to mean: ‘where all members of the organisation work together on an ongoing basis improving processes and reducing errors to improve overall performance for the customer’ (Fryer, Antony, and Douglas, 2007, p. 498). This report is required, because although CI has been on the agenda for many years for Public Services Organisations there has not been a review as to how this has progressed recently

Large-N limit of a magnetic impurity in unconventional density waves

We investigate the effect of unconventional density wave (UDW) condensate on an Anderson impurity using large-N technique at T=0. In accordance with previous treatments of a Kondo impurity in pseudogap phases, we find that Kondo effect occurs only in a certain range of parameters. The f-electron density of states reflects the influence of UDW at low energies and around the maximum of the density wave gap. The static spin susceptibility diverges at the critical coupling, indicating the transition from strong to weak coupling. In the dynamic spin susceptibility an additional peak appears showing the presence the UDW gap. Predictions concerning non-linear density of states are made. Our results apply to other unconventional condensates such as d-wave superconductors and d-density waves as well.Comment: 9 pages, 7 figure

Changes in Exercise Data Management

The suite of exercise hardware aboard the International Space Station (ISS) generates an immense amount of data. The data collected from the treadmill, cycle ergometer, and resistance strength training hardware are basic exercise parameters (time, heart rate, speed, load, etc.). The raw data are post processed in the laboratory and more detailed parameters are calculated from each exercise data file. Updates have recently been made to how this valuable data are stored, adding an additional level of data security, increasing data accessibility, and resulting in overall increased efficiency of medical report delivery. Questions regarding exercise performance or how exercise may influence other variables of crew health frequently arise within the crew health care community. Inquiries over the health of the exercise hardware often need quick analysis and response to ensure the exercise system is operable on a continuous basis. Consolidating all of the exercise system data in a single repository enables a quick response to both the medical and engineering communities. A SQL server database is currently in use, and provides a secure location for all of the exercise data starting at ISS Expedition 1 - current day. The database has been structured to update derived metrics automatically, making analysis and reporting available within minutes of dropping the inflight data it into the database. Commercial tools were evaluated to help aggregate and visualize data from the SQL database. The Tableau software provides manageable interface, which has improved the laboratory's output time of crew reports by 67%. Expansion of the SQL database to be inclusive of additional medical requirement metrics, addition of 'app-like' tools for mobile visualization, and collaborative use (e.g. operational support teams, research groups, and International Partners) of the data system is currently being explored