Beneficios para la industria, como hacer un uso responsable de la energía - Ejemplo de una auditoria energética en una industria alimenticia

Se presenta en este trabajo un estudio de auditoría energética en una industria. Para el mismo se efectuó una caracterización de las instalaciones y se realizaron mediciones de las magnitudes involucradas. Finalmente se presentan distintas acciones y una serie de medidas a implementar a los efectos de hacer un uso más eficiente de la energía, logrando importantes ahorros anuales de energía. La importancia del presente estudio se basa en lo importante que es realizar una auditoria energética ya que se puede definir como una investigación integral de todos y cada uno de los aspectos, tanto técnicos como económicos, que afectan directa o bien de forma indirecta al consumo de las distintas energías. Teniendo además en cuenta que el uso eficiente de la energía es una condición necesaria para la sustentabilidad energética y ambiental a largo plazo.A study of an energy audit is presented in this paper in a refrigerating industry. For the same characterization of the facility was performed and measurements of the magnitudes involved were made. Finally different actions and a series of measures to be implemented for the purpose of making more efficient use of energy, achieving significant annual energy savings are presented. The importance of this study is based on how important it is to perform an energy audit as it can be defined as a comprehensive research of each and every one of the aspects, both technical and economic, affecting directly and indirectly the consumption of different energies. Considering also that the efficient use of energy is a necessary condition for energy and long-term environmental sustainability.Tema 7: Uso eficiente y racional de la energía. Políticas y economía energética.Facultad de Arquitectura y Urbanism

Beneficios para la industria, como hacer un uso responsable de la energía - Ejemplo de una auditoria energética en una industria alimenticia

Se presenta en este trabajo un estudio de auditoría energética en una industria. Para el mismo se efectuó una caracterización de las instalaciones y se realizaron mediciones de las magnitudes involucradas. Finalmente se presentan distintas acciones y una serie de medidas a implementar a los efectos de hacer un uso más eficiente de la energía, logrando importantes ahorros anuales de energía. La importancia del presente estudio se basa en lo importante que es realizar una auditoria energética ya que se puede definir como una investigación integral de todos y cada uno de los aspectos, tanto técnicos como económicos, que afectan directa o bien de forma indirecta al consumo de las distintas energías. Teniendo además en cuenta que el uso eficiente de la energía es una condición necesaria para la sustentabilidad energética y ambiental a largo plazo.A study of an energy audit is presented in this paper in a refrigerating industry. For the same characterization of the facility was performed and measurements of the magnitudes involved were made. Finally different actions and a series of measures to be implemented for the purpose of making more efficient use of energy, achieving significant annual energy savings are presented. The importance of this study is based on how important it is to perform an energy audit as it can be defined as a comprehensive research of each and every one of the aspects, both technical and economic, affecting directly and indirectly the consumption of different energies. Considering also that the efficient use of energy is a necessary condition for energy and long-term environmental sustainability.Tema 7: Uso eficiente y racional de la energía. Políticas y economía energética.Facultad de Arquitectura y Urbanism

Leptin and Fasting Regulate Rat Gastric Glucose-Regulated Protein 58

The stomach secretes a wide range of peptides with essential metabolic functions, and thereby plays an important role in the regulation of energy homeostasis. Disulfide isomerase glucose-regulated protein 58 (GRp58) is a molecular chaperone member of the endoplasmic reticulum (ER) stress signaling pathway, which is a marker for human gastric cancer. Since GRp58 seems to be regulated by a phosphorylation/dephosphorylation pattern shift, we used the 2DE gel methodology and peptide mass fingerprinting-protein identification by means of MALDI-TOF mass spectrometry. We show that gastric mucosa GRp58 is dephosphorylated by fasting, and this effect is blunted when fasted rats are treated with leptin. Furthermore, we assessed the gene expression of GRp58 under different physiological settings known to be associated with energy homeostasis (fasting, leptin treatment and leptin deficiency). We found that intraperitoneal administration of leptin increases whereas leptin deficiency decreases GRp58 mRNA levels. However, GRp58 expression remains unchanged after fasting, indicating that leptin actions on GRp58 are no direct sensitivity to fasting. Dissection of the molecular pathways mediating the interactions between ER stress-related factors and nutrient availability, as well as their target genes, may open a new avenue for the study of obesity and other metabolic disorders

Maternal Serum Meteorin Levels and the Risk of Preeclampsia

BACKGROUND: Meteorin (METRN) is a recently described neutrophic factor with angiogenic properties. This is a nested case-control study in a longitudinal cohort study that describes the serum profile of METRN during different periods of gestation in healthy and preeclamptic pregnant women. Moreover, we explore the possible application of METRN as a biomarker. METHODS AND FINDINGS: Serum METRN was measured by ELISA in a longitudinal prospective cohort study in 37 healthy pregnant women, 16 mild preeclamptic women, and 20 healthy non-pregnant women during the menstrual cycle with the aim of assessing serum METRN levels and its correlations with other metabolic parameters. Immunostaining for METRN protein was performed in placenta. A multivariate logistic regression model was proposed and a classifier model was formulated for predicting preeclampsia in early and middle pregnancy. The performance in classification was evaluated using measures such as sensitivity, specificity, and the receiver operating characteristic (ROC) curve. In healthy pregnant women, serum METRN levels were significantly elevated in early pregnancy compared to middle and late pregnancy. METRN levels are significantly lower only in early pregnancy in preeclamptic women when compared to healthy pregnant women. Decision trees that did not include METRN levels in the first trimester had a reduced sensitivity of 56% in the detection of preeclamptic women, compared to a sensitivity of 69% when METRN was included. CONCLUSIONS: The joint measurements of circulating METRN levels in the first trimester and systolic blood pressure and weight in the second trimester significantly increase the probabilities of predicting preeclampsia

La producción de la Universidad española en Física, reflejada en las publicaciones españolas y extranjeras

The scientific productíon of Spanish Universities in the field of Physics for the period 1986-88 is analyzed with data obtaincd from two databases: INSPEC, whích covcrs publications in foreign journals and also, but only in a selective way, those published in a certain numbcr of Spanísh journals; and ICYT, which covcrs comprehcnsively ali original papcrs published in Spanish journals. Comparison of the two series of data Ieads to ccrtain conclusions as rcgards the trends to publish in foreign journals. A further comparison is made betwcen the periods 1982-85 and 1986-88, with thc data obtained from INSPEC.Se analiza la producción científica de la Universidad española en el campo de la Física, y en el período 1986-88, a través de dos bases de datos: INSPEC, que recoge lo publicado en revistas extranjeras y también, aunque de modo selectivo, en cierto número de revistas españolas; e ICYT, que recoge exhaustivamente todos los trabajos originales publicados en revistas españolas. La comparación entre ambas series de datos permite deducir tendencias de publícación en el extranjero. Asimismo se analizan comparativamente los periodos 1982-85 y 1986-88, con los datos obtenidos de INSPEC

Desarrollo de un estudio-diagnóstico energético en Santa Cruz: : hallazgos y aspectos relevantes para la transición energética

El presente trabajo desarrolla el diseño y ejecución a lo largo de un semestre de 2023 de un estudio-diagnóstico energético en la provincia de Santa Cruz, que incluyó aspectos técnicos relacionados con la producción, consumo e intercambios de energía, incorporando herramientas SIG y simulaciones para prever aspectos como uso de energía renovable para reemplazo de combustibles líquidos en generación eléctrica en sistemas aislados, y producción de hidrógeno verde a través de energía eólica. Se incluyó un abordaje social a través de la realización de encuentros participativos en la mayoría de las localidades de la provincia para conocer problemáticas y necesidades locales en aspectos energéticos, y discutir posibles soluciones. Se involucraron expertos locales, regionales y de otros países para obtener un diagnóstico actualizado de esta temática

Association of interatrial septal abnormalities with cardiac impulse conduction disorders in adult patients: experience from a tertiary center in Kosovo

Interatrial septal disorders, which include: atrial septal defect, patent foramen ovale and atrial septal aneurysm, are frequent congenital anomalies found in adult patients. Early detection of these anomalies is important to prevent their hemodynamic and/or thromboembolic consequences. The aims of this study were: to assess the association between impulse conduction disorders and anomalies of interatrial septum; to determine the prevalence of different types of interatrial septum abnormalities; to assess anatomic, hemodynamic, and clinical consequences of interatrial septal pathologies. Fifty-three adult patients with impulse conduction disorders and patients without ECG changes but with signs of interatrial septal abnormalities, who were referred to our center for echocardiography, were included in a prospective transesophageal echocardiography study. Interatrial septal anomalies were detected in around 85% of the examined patients. Patent foramen ovale was encountered in 32% of the patients, and in combination with atrial septal aneurysm in an additional 11.3% of cases. Atrial septal aneurysm and atrial septal defect were diagnosed with equal frequency in 20.7% of our study population. Impulse conduction disorders were significantly more suggestive of interatrial septal anomalies than clinical signs and symptoms observed in our patients (84.91% vs 30.19%, P=0.002). Right bundle branch block was the most frequent impulse conduction disorder, found in 41 (77.36%) cases. We conclude that interatrial septal anomalies are highly associated with impulse conduction disorders, particularly with right bundle branch block. Impulse conduction disorders are more indicative of interatrial septal abnormalities in earlier stages than can be understood from the patient’s clinical condition

Randomized control trial of a childhood obesity prevention family-based program: “Abriendo Caminos” and effects on BMI

Background: Hispanic individuals are at increased risk for obesity and other chronic health conditions. This article evaluates the effect of a family-based, childhood obesity primary prevention intervention in a community setting. Methods: A multi-site, randomized controlled trial community program with assessments at pre (T0), post-program (T1), and 6-months post-program (T2). Participating families were recruited from five sites. Only families of Mexican or Puerto Rican heritage with a least one child between 6 and 18 years were included in the study, without weight restrictions. Families were randomized to the intervention and control arms. Intervention families received six-2 h weekly workshops. Control families received printed generic nutrition and wellness information. Heights and weights were measured at the 3-time points to calculate BMI z-scores, BMI-percentiles, and weight status using age- and sex-specific growth charts, according to the CDC guidelines. Results: There were no differences in BMI-z scores between children in the intervention (n = 239) and control groups (n = 187) at T0. BMI z-scores decreased in the intervention group (−0.03, 95% CI, −0.066, −0.003, p = 0.032) at T1, but not in the control group at T1. Changes in BMI z-scores were not statistically significant at T2. Conclusion: The Abriendo Caminos intervention effectively prevented unhealthy weight gain in Hispanic children in the short-term, but not at 6-months post-intervention. Younger children and girls benefited more from the program at 6-months post-intervention. Additional efforts are needed to sustain long-term changes. Culturally-tailored programs can provide families with the knowledge to produce short-term changes and a potential pathway for sustainable changes in implementing healthy behaviors.This article is published as Teran-Garcia M, Hammons AJ, Olvera N, Greder K, Plaza-Delrestre M, Andrade FCD, Fiese B and Wiley AR (2023) Randomized control trial of a childhood obesity prevention family-based program: “Abriendo Caminos” and effects on BMI. Front. Pediatr. 11:1137825. doi: 10.3389/fped.2023.113782

Multiple myeloma and SARS-CoV-2 infection : clinical characteristics and prognostic factors of inpatient mortality

There is limited information on the characteristics, prognostic factors, and outcomes of patients with multiple myeloma (MM) hospitalized with COVID-19. This retrospective case series investigated 167 patients reported from 73 hospitals within the Spanish Myeloma Collaborative Group network in March and April, 2020. Outcomes were compared with 167 randomly selected, contemporary, age-/sex-matched noncancer patients with COVID-19 admitted at six participating hospitals. Among MM and noncancer patients, median age was 71 years, and 57% of patients were male; 75 and 77% of patients, respectively, had at least one comorbidity. COVID-19 clinical severity was moderate-severe in 77 and 89% of patients and critical in 8 and 4%, respectively. Supplemental oxygen was required by 47 and 55% of MM and noncancer patients, respectively, and 21%/9% vs 8%/6% required noninvasive/invasive ventilation. Inpatient mortality was 34 and 23% in MM and noncancer patients, respectively. Among MM patients, inpatient mortality was 41% in males, 42% in patients aged >65 years, 49% in patients with active/progressive MM at hospitalization, and 59% in patients with comorbid renal disease at hospitalization, which were independent prognostic factors on adjusted multivariate analysis. This case series demonstrates the increased risk and identifies predictors of inpatient mortality among MM patients hospitalized with COVID-19

Estudio de calidad de la adherencia a la primera etapa de implementación de un protocolo de sedoanalgesia en una UCI médico-quirúrgica

Recomendaciones actuales sugieren manejar sedoanalgesia (SA) ligera y guiada por objetivos en pacientes en ventilación mecánica (VM). Datos previos de nuestra UCI (2010) de evaluación del estado de alerta con escala de RASS, indicaron un nivel de sedación profunda. La indicación se realizaba según el criterio de cada médico tratante. Surge la iniciativa del diseño e implementación de un protocolo de SA en etapas, para hacer frente a este problemaFacultad de Ciencias Médicas (FCM