Peripersonal space: a multisensory interface for body-object interactions

Research in the last four decades has brought a considerable advance in our understanding of how the brain synthesizes information arising from different sensory modalities. Indeed, many cortical and subcortical areas, beyond those traditionally considered to be ‘associative,’ have been shown to be involved in multisensory interaction and integration (Ghazanfar and Schroeder 2006). Visuo-tactile interaction is of particular interest, because of the prominent role played by vision in guiding our actions and anticipating their tactile consequences in everyday life. In this chapter, we focus on the functional role that visuo-tactile processing may play in driving two types of body-object interactions: avoidance and approach. We will first review some basic features of visuo-tactile interactions, as revealed by electrophysiological studies in monkeys. These will prove to be relevant for interpreting the subsequent evidence arising from human studies. A crucial point that will be stressed is that these visuo-tactile mechanisms have not only sensory, but also motor-related activity that qualifies them as multisensory-motor interfaces. Evidence will then be presented for the existence of functionally homologous processing in the human brain, both from neuropsychological research in brain-damaged patients and in healthy participants. The final part of the chapter will focus on some recent studies in humans showing that the human motor system is provided with a multisensory interface that allows for continuous monitoring of the space near the body (i.e., peripersonal space). We further demonstrate that multisensory processing can be modulated on-line as a consequence of interacting with objects. This indicates that, far from being passive, the monitoring of peripersonal space is an active process subserving actions between our body and objects located in the space around us

An update on THORPEX-related research in data assimilation and observing strategies

International audienceThe international programme "THORPEX: a World Weather Research Programme" provides a framework in which to tackle the challenge of improving the forecast skill of high-impact weather through international collaboration between academic institutions, operational forecast centres, and users of forecast products. The objectives of the THORPEX Data Assimilation and Observation Strategy Working Group (DAOS-WG) are two-fold. The primary goal is to assess the impact of observations and various targeting methods to provide guidance for observation campaigns and for the configuration of the Global Observing System. The secondary goal is to setup an optimal framework for data assimilation, including aspects such as targeted observations, satellite data, background error covariances and quality control. The Atlantic THORPEX Regional campaign, ATReC, in 2003, has been very successful technically and has provided valuable datasets to test targeting issues. Various data impact experiments have been performed, showing a small but very slightly positive impact of targeted observations. Projects of the DAOS-WG include working on the AMMA field experiment, in the context of IPY and to prepare the future THORPEX-PARC field campaign in the Pacific by comparing sensitivity of the forecasts to observations between several groups

Theoretical and numerical studies of wave-packet propagation in tokamak plasmas

Theoretical and numerical studies of wave-packet propagation are presented to analyze the time varying 2D mode structures of electrostatic fluctuations in tokamak plasmas, using general flux coordinates. Instead of solving the 2D wave equations directly, the solution of the initial value problem is used to obtain the 2D mode structure, following the propagation of wave-packets generated by a source and reconstructing the time varying field. As application, the 2D WKB method is applied to investigate the shaping effects (elongation and triangularity) of tokamak geometry on the lower hybrid wave propagation and absorbtion. Meanwhile, the Mode Structure Decomposition (MSD) method is used to handle the boundary conditions and simplify the 2D problem to two nested 1D problems. The MSD method is related to that discussed earlier by Zonca and Chen [Phys. Fluids B 5, 3668 (1993)], and reduces to the well-known "ballooning formalism" [J. W. Connor, R. J. Hastie, and J. B. Taylor, Phys. Rev. Lett. 40, 396 (1978)], when spatial scale separation applies. This method is used to investigate the time varying 2D electrostatic ITG mode structure with a mixed WKB-full-wave technique. The time varying field pattern is reconstructed and the time asymptotic structure of the wave-packet propagation gives the 2D eigenmode and the corresponding eigenvalue. As a general approach to investigate 2D mode structures in tokamak plasmas, our method also applies for electromagnetic waves with general source/sink terms, either by an internal/external antenna or nonlinear wave interaction with zonal structures.Comment: 24 pages, 14 figure

Per3 length polymorphism in patients with type 2 diabetes mellitus

BACKGROUND: A number of observations support the involvement of circadian clock genes in the regulation of metabolic processes. One of these circadian genes, Per3, exhibits a variable number tandem repeat length polymorphism, consisting of two alleles, namely four and five repeat alleles, in its exon 18. The objective of this study was to examine the existence of Per3 variants in patients with type 2 diabetes mellitus (T2DM) as compared to a non T2DM control group. METHODS: Intravenous blood samples were collected to obtain white blood cells from 302 T2DM patients and 330 non-diabetic, age- and sex-matched, individuals. Per3 genotyping was performed on DNA by polymerase chain reaction. RESULTS: Frequency of five repeat allele was higher, and that of four repeat allele lower, in T2DM patients as compared to non-diabetic controls (χ2=6.977, p=0.0082) CONCLUSIONS: The results indicate an association of Per3 five repeat allele with T2DM occurrence and suggest that individuals with five repeat allele may be at a greater risk for T2DM as compared to those carrying the four repeat allele.Fil: Karthikeyan, Ramanujam. Madurai Kamaraj University. School of Biological Sciences. Department of Animal Behaviour and Physiology; IndiaFil: Marimuthu, Ganapathy. Madurai Kamaraj University. School of Biological Sciences. Department of Animal Behaviour and Physiology; IndiaFil: Sooriyakumar, Murugesan. Madurai Medical College. Department of Medicine; IndiaFil: BaHammam, Ahmed S.. King Saud University. College of Medicine; Arabia SauditaFil: Spence, David Warren.Fil: Pandi Perumal, Seithikurippu R.. Somnogen Canada; CanadáFil: Brown, Gregory M.. University of Toronto; CanadáFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Brief Communication: Rapid mapping of landslide events: the 3 December 2013 Montescaglioso landslide, Italy

We present an approach to measure 3-D surface deformations caused by large, rapid-moving landslides using the amplitude information of high-resolution, X-band synthetic aperture radar (SAR) images. We exploit SAR data captured by the COSMO-SkyMed satellites to measure the deformation produced by the 3 December 2013 Montescaglioso landslide, southern Italy. The deformation produced by the deep-seated landslide exceeded 10 m and caused the disruption of a main road, a few homes and commercial buildings. The results open up the possibility of obtaining 3-D surface deformation maps shortly after the occurrence of large, rapid-moving landslides using high-resolution SAR data

Melatonin and Human Cardiovascular Disease

The possible therapeutic role of melatonin in the pathophysiology of coronary artery disorder (CAD) is increasingly being recognized. In humans, exogenous melatonin has been shown to decrease nocturnal hypertension, improve systolic and diastolic blood pressure, reduce the pulsatility index in the internal carotid artery, decrease platelet aggregation, and reduce serum catecholamine levels. Low circulating levels of melatonin are reported in individuals with CAD, arterial hypertension, and congestive heart failure. This review assesses current literature on the cardiovascular effects of melatonin in humans. It can be concluded that melatonin deserves to be considered in clinical trials evaluating novel therapeutic interventions for cardiovascular disorders.Fil: Pandi Perumal, Seithikurippu R.. King Saud University; Arabia SauditaFil: BaHammam, Ahmed S.. King Saud University; Arabia SauditaFil: Ojike, Nwakile I.. King Saud University; Arabia SauditaFil: Akinseye, Oluwaseun A.. University of New York; Estados UnidosFil: Kendzerska, Tetyana. Sunnybrook Health Sciences Center; CanadáFil: Buttoo, Kenneth. Sleep Disorders Center; CanadáFil: Dhandapany, Perundurai S.. Oregon Health And Science University; Estados UnidosFil: Brown, Gregory M.. University of Toronto; CanadáFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina ; Argentin

Status of the PANDA barrel DIRC

The PANDA experiment at the future Facility for Antiproton and Ion Research in Europe GmbH (FAIR) at GSI, Darmstadt will study fundamental questions of hadron physics and QCD using high-intensity cooled antiproton beams with momenta between 1.5 and 15 GeV/c. Hadronic PID in the barrel region of the PANDA detector will be provided by a DIRC (Detection of Internally Reflected Cherenkov light) counter. The design is based on the successful BABAR DIRC with several key improvements, such as fast photon timing and a compact imaging region. Detailed Monte Carlo simulation studies were performed for DIRC designs based on narrow bars or wide plates with a variety of focusing solutions. The performance of each design was characterized in terms of photon yield and single photon Cherenkov angle resolution and a maximum likelihood approach was used to determine the π/K separation. Selected design options were implemented in prototypes and tested with hadronic particle beams at GSI and CERN. This article describes the status of the design and R&D for the PANDA Barrel DIRC detector, with a focus on the performance of different DIRC designs in simulation and particle beams

Métodos analíticos desenvolvidos para o monitoramento da doença citrus greening em laranja doce: imagens de fluorescência e espectroscopia de emissão óptica com plasma induzido por laser (LIBS).

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