Conflicting interests in the pathogen-host tug of war : fungal micronutrient scavenging versus mammalian nutritional immunity

Funding: The authors are supported by the European Research Council (STRIFE project funded on grant number ERC-2009-AdG-249793, http://erc.europa.eu). AJPB is also supported by the Wellcome Trust (grant numbers 080088, 097377, www.wellcome.ac.uk) and the UK Biotechnology and Biological Sciences Research Council (grant number BB/F00513X/1, www.bbsrc.ac.uk). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Precision searches in dijets at the HL-LHC and HE-LHC

This paper explores the physics reach of the High-Luminosity Large Hadron Collider (HL-LHC) for searches of new particles decaying to two jets. We discuss inclusive searches in dijets and b-jets, as well as searches in semi-inclusive events by requiring an additional lepton that increases sensitivity to different aspects of the underlying processes. We discuss the expected exclusion limits for generic models predicting new massive particles that result in resonant structures in the dijet mass. Prospects of the Higher-Energy LHC (HE-LHC) collider are also discussed. The study is based on the Pythia8 Monte Carlo generator using representative event statistics for the HL-LHC and HE-LHC running conditions. The event samples were created using supercomputers at NERSC.Comment: 27 pages, 19 figure

New Clox Systems for rapid and efficient gene disruption in Candida albicans

Acknowledgements: We are grateful to Janet Quinn, Lila Kastora, Joanna Potrykus, Michelle Leach, and others for sharing their experiences with the Clox cassettes. We thank Julia Kohler for her kind gift of the NAT1-flipper plasmid pJK863, Claudia Jacob for her advice with In-fusion cloning, and our colleagues in the Aberdeen Fungal Group for numerous stimulating discussions. Data Availability: The authors confirm that all data underlying the findings are fully available without restriction. The sequences of all Clox cassettes are available in GenBank: URA3-Clox (loxP-URA3-MET3p-cre-loxP): GenBank accession number KC999858. NAT1-Clox (loxP-NAT1-MET3p-cre-loxP): GenBank accession number KC999859. LAL (loxP-ARG4-loxP): GenBank accession number DQ015897. LHL (loxP-HIS1-loxP): GenBank accession number DQ015898. LUL (loxP-URA3-loxP): GenBank accession number DQ015899. Funding: This work was supported by the Wellcome Trust (www.wellcome.ac.uk): S.S., F.C.O., N.A.R.G., A.J.P.B. (080088); N.A.R.G., A.J.P.B. (097377). The authors also received support from the European Research Council [http://erc.europa.eu/]: DSC. ERB, AJPB (STRIFE Advanced Grant; C-2009-AdG-249793). The European Commission also provided funding [http://ec.europa.eu/research/fp7]: I.B., A.J.P.B. (FINSysB MC-ITN; PITN-GA-2008-214004). Also the UK Biotechnology and Biological Research Council provided support [www.bbsrc.ac.uk]: N.A.R.G., A.J.P.B. (Research Grant; BB/F00513X/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

08441 Abstracts Collection -- Emerging Uses and Paradigms for Dynamic Binary Translation

From 26.10. to 31.10.2008, the Dagstuhl Seminar 08441 ``Emerging Uses and Paradigms for Dynamic Binary Translation \u27\u27 was held in Schloss Dagstuhl~--~Leibniz Center for Informatics. During the seminar, several participants presented their current research, and ongoing work and open problems were discussed. Abstracts of the presentations given during the seminar as well as abstracts of seminar results and ideas are put together in this paper. The first section describes the seminar topics and goals in general. Links to extended abstracts or full papers are provided, if available

Orbital Magnetism and Current Distribution of Two-Dimensional Electrons under Confining Potential

The spatial distribution of electric current under magnetic field and the resultant orbital magnetism have been studied for two-dimensional electrons under a harmonic confining potential V(\vecvar{r})=m \omega_0^2 r^2/2 in various regimes of temperature and magnetic field, and the microscopic conditions for the validity of Landau diamagnetism are clarified. Under a weak magnetic field (\omega_c\lsim\omega_0, \omega_c being a cyclotron frequency) and at low temperature (T\lsim\hbar\omega_0), where the orbital magnetic moment fluctuates as a function of the field, the currents are irregularly distributed paramagnetically or diamagnetically inside the bulk region. As the temperature is raised under such a weak field, however, the currents in the bulk region are immediately reduced and finally there only remains the diamagnetic current flowing along the edge. At the same time, the usual Landau diamagnetism results for the total magnetic moment. The origin of this dramatic temperature dependence is seen to be in the multiple reflection of electron waves by the boundary confining potential, which becomes important once the coherence length of electrons gets longer than the system length. Under a stronger field (\omega_c\gsim\omega_0), on the other hand, the currents in the bulk region cause de Haas-van Alphen effect at low temperature as T\lsim\hbar\omega_c. As the temperature gets higher (T\gsim\hbar\omega_c) under such a strong field, the bulk currents are reduced and the Landau diamagnetism by the edge current is recovered.Comment: 15 pages, 11 figure

Continuous monitoring of mining induced strain in a road pavement using fiber Bragg grating sensors

Abstrakt Få samhällsproblem har under de senaste åren mött så allmän uppmärksamhet som ungdomsbrottsligheten. Den polisanmälda ungdomsbrottsligheten har i stort sett följt brottslighetens utvecklingskurva avseende antal begångna brott, denna kurva visar en tydlig ökning sedan efterkrigstiden. Detta är en komparativ uppsats som är inriktad på ungdomsbrottsligheten i två av Malmö stadsdelar där vi undersöker antalet polisanmälda ungdomar till socialtjänsten mellan åren 2007-2009. Vi har studerat vilka brott ungdomarna var anmälda, analyserat brottstrender och i den mån det var möjligt granskat hur könsfördelningen har sett ut. Vi har undersökt vilka insatser som tillämpas från socialtjänstens håll för att motverka ungdomsbrottslighet samt förhindra fortsatt brottslighet hos redan polisanmälda ungdomar samt granska hur socialsekreterare vid våra undersökningsverksamheter upplever och uppfattar ungdomsbrottsligheten. Våra resultat har delvis ställts i relation till hur ungdomsbrottsligheten enligt tidigare forskning och redan befintlig statistik ser ut i Sverige. Vi har i uppsatsen använt oss av kvalitativ och kvantitativ datainsamlingsmetod samt ställt analysavsnitt och diskussionsavsnitt i relation till tidigare forskning och den av Travis Hirschis konstruerade teorin om sociala band. Studiens resultat visar bland annat att antalet polisanmälningar till socialtjänsterna har ökat, att killar begår fler brott än tjejer, att brottstyperna skiljer sig åt beroende på kön samt att ett mindre antal ungdomar ansvarar för en stor del av socialtjänsternas inkomna polisanmälningar

A Spin Modulated Telescope to Make Two Dimensional CMB Maps

We describe the HEMT Advanced Cosmic Microwave Explorer (HACME), a balloon borne experiment designed to measure sub-degree scale Cosmic Microwave Background anisotropy over hundreds of square degrees, using a unique two dimensional scanning strategy. A spinning flat mirror that is canted relative to its spin axis modulates the direction of beam response in a nearly elliptical path on the sky. The experiment was successfully flown in February of 1996, achieving near laboratory performance for several hours at float altitude. A map free of instrumental systematic effects is produced for a 3.5 hour observation of 630 square degrees, resulting in a flat band power upper limit of (l(l+1)C_l/2 pi)^0.5 < 77 microK at l = 38 (95% confidence). The experiment design, flight operations and data, including atmospheric effects and noise performance, are discussed.Comment: 4 pages, 3 figure

Anomalous Exponent of the Spin Correlation Function of a Quantum Hall Edge

The charge and spin correlation functions of partially spin-polarized edge electrons of a quantum Hall bar are studied using effective Hamiltonian and bosonization techniques. In the presence of the Coulomb interaction between the edges with opposite chirality we find a different crossover behavior in spin and charge correlation functions. The crossover of the spin correlation function in the Coulomb dominated regime is characterized by an anomalous exponent, which originates from the finite value of the effective interaction for the spin degree of freedom in the long wavelength limit. The anomalous exponent may be determined by measuring nuclear spin relaxation rates in a narrow quantum Hall bar or in a quantum wire in strong magnetic fields.Comment: 4 pages, Revtex file, no figures. To appear in Physical Revews B, Rapid communication