Development of an experimental 10 T Nb3Sn dipole magnet for the CERN LHC

An experimental 1-m long twill aperture dipole magnet developed using a high-current Nb3Sn conductor in order to attain a magnetic field well beyond 10 T at 4.2 K is described. The emphasis in this Nb3Sn project is on the highest possible field within the known Large Hadron Collider (LHC) twin-aperture configuration. A design target of 11.5 T was chosen

Extended microsatellite analysis in microsatellite stable, MSH2 and MLH1 mutation-negative HNPCC patients: Genetic reclassification and correlation with clinical features

Background: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder predisposing to predominantly colorectal cancer (CRC) and endometrial cancer frequently due to germline mutations in DNA mismatch repair (MMR) genes, mainly MLH1, MSH2 and also MSH6 in families seen to demonstrate an excess of endometrial cancer. As a consequence, tumors in HNPCC reveal alterations in the length of simple repetitive genomic sequences like poly-A, poly-T, CA or GT repeats (microsatellites) in at least 90% of the cases. Aim of the Study: The study cohort consisted of 25 HNPCC index patients ( 19 Amsterdam positive, 6 Bethesda positive) who revealed a microsatellite stable (MSS) - or low instable (MSI-L) - tumor phenotype with negative mutation analysis for the MMR genes MLH1 and MSH2. An extended marker panel (BAT40, D10S197, D13S153, D18S58, MYCL1) was analyzed for the tumors of these patients with regard to three aspects. First, to reconfirm the MSI-L phenotype found by the standard panel; second, to find minor MSIs which might point towards an MSH6 mutation, and third, to reconfirm the MSS status of hereditary tumors. The reconfirmation of the MSS status of tumors not caused by mutations in the MMR genes should allow one to define another entity of hereditary CRC. Their clinical features were compared with those of 150 patients with sporadic CRCs. Results: In this way, 17 MSS and 8 MSI-L tumors were reclassified as 5 MSS, 18 MSI-L and even 2 MSI-H ( high instability) tumors, the last being seen to demonstrate at least 4 instable markers out of 10. Among all family members, 87 malignancies were documented. The mean age of onset for CRCs was the lowest in the MSI-H-phenotyped patients with 40.5 +/- 4.9 years (vs. 47.0 +/- 14.6 and 49.8 +/- 11.9 years in MSI-L- and MSS-phenotyped patients, respectively). The percentage of CRC was the highest in families with MSS-phenotyped tumors (88%), followed by MSI-L-phenotyped ( 78%) and then by MSI-H-phenotyped (67%) tumors. MSS tumors were preferentially localized in the distal colon supposing a similar biologic behavior like sporadic CRC. MSH6 mutation analysis for the MSI-L and MSI-H patients revealed one truncating mutation for a patient initially with an MSS tumor, which was reclassified as MSI-L by analyzing the extended marker panel. Conclusion: Extended microsatellite analysis serves to evaluate the sensitivity of the reference panel for HNPCC detection and permits phenotype confirmation or upgrading. Additionally, it confirms the MSS status of hereditary CRCs not caused by the common mutations in the MMR genes and provides hints to another entity of hereditary CRC. Copyright (C) 2004 S. Karger AG, Basel

Updated analysis of NN elastic scattering to 3 GeV

A partial-wave analysis of NN elastic scattering data has been updated to include a number of recent measurements. Experiments carried out at the Cooler Synchrotron (COSY) by the EDDA Collaboration have had a significant impact above 1 GeV. Results are discussed in terms of the partial-wave and direct-reconstruction amplitudes.Comment: 16 pages, 14 figures, 2 tables; Fig 10 error corrected; Accepted for publication in Physical Review

Tight Bounds for MIS in Multichannel Radio Networks

Daum et al. [PODC'13] presented an algorithm that computes a maximal independent set (MIS) within $O(\log^2 n/F+\log n \mathrm{polyloglog} n)$ rounds in an $n$-node multichannel radio network with $F$ communication channels. The paper uses a multichannel variant of the standard graph-based radio network model without collision detection and it assumes that the network graph is a polynomially bounded independence graph (BIG), a natural combinatorial generalization of well-known geographic families. The upper bound of that paper is known to be optimal up to a polyloglog factor. In this paper, we adapt algorithm and analysis to improve the result in two ways. Mainly, we get rid of the polyloglog factor in the runtime and we thus obtain an asymptotically optimal multichannel radio network MIS algorithm. In addition, our new analysis allows to generalize the class of graphs from those with polynomially bounded local independence to graphs where the local independence is bounded by an arbitrary function of the neighborhood radius.Comment: 37 pages, to be published in DISC 201

Search for Exotic Muon Decays

Recently, it has been proposed that the observed anomaly in the time distribution of neutrino induced reactions, reported by the KARMEN collaboration, can be interpreted as a signal from an exotic muon decay branch mu+ to e+ X. It has been shown that this hypothesis gives an acceptable fit to the KARMEN data if the boson X has a mass of m_X=103.9MeV/c^2, close to the kinematical limit. We have performed a search for the X particle by studying for the first time the very low energy part of the Michel spectrum in mu+ decays. Using a HPGe detector setup at the muE4 beamline at PSI we find branching ratios BR(mu+ to e+ X)<5.7e-4 (90% C.L.) for most of the region 103MeV/c^2<m_X<105MeV/c^2.Comment: 9 page

Mechanical Properties of Boehmite Evaluated by Atomic Force Microscopy Experiments and Molecular Dynamic Finite Element Simulations

Boehmite nanoparticles show great potential in improving mechanical properties of fiber reinforced polymers. In order to predict the properties of nanocomposites, knowledge about the material parameters of the constituent phases, including the boehmite particles, is crucial. In this study, the mechanical behavior of boehmite is investigated using Atomic Force Microscopy (AFM) experiments and Molecular Dynamic Finite Element Method (MDFEM) simulations. Young's modulus of the perfect crystalline boehmite nanoparticles is derived from numerical AFM simulations. Results of AFM experiments on boehmite nanoparticles deviate significantly. Possible causes are identified by experiments on complementary types of boehmite, that is, geological and hydrothermally synthesized samples, and further simulations of imperfect crystals and combined boehmite/epoxymodels. Under certain circumstances, the mechanical behavior of boehmite was found to be dominated by inelastic effects that are discussed in detail in the present work. The studies are substantiated with accompanying X-ray diffraction and Raman experiments.DFG/FOR/202

The influence of the geomagnetic field and of the uncertainties in the primary spectrum on the development of the muon flux in the atmosphere

In this paper we study the sensitivity of the flux of atmospheric muons to uncertainties in the primary cosmic ray spectrum and to the treatment of the geomagnetic field in a calculation. We use the air shower simulation program AIRES to make the calculation for two different primary spectra and under several approximations to the propagation of charged particles in the geomagnetic field. The results illustrate the importance of accurate modelling of the geomagnetic field effects. We propose a high and a low fit of the proton and helium fluxes, and calculate the muon fluxes with these different inputs. Comparison with measurements of the muon flux by the CAPRICE experiment shows a slight preference for the higher primary cosmic ray flux parametrization.Comment: 24 pages, 13 figures, submitted to Phys.Rev.

The Semiclassical Limit of Causal Dynamical Triangulations

Previous work has shown that the macroscopic structure of the theory of quantum gravity defined by causal dynamical triangulations (CDT) is compatible with that of a de Sitter universe. After emphasizing the strictly nonperturbative nature of this semiclassical limit we present a detailed study of the three-volume data, which allows us to re-confirm the de Sitter structure, exhibit short-distance discretization effects, and make a first detailed investigation of the presence of higher-order curvature terms in the effective action for the scale factor. Technically, we make use of a novel way of fixing the total four-volume in the simulations.Comment: 30 pages, 10 figure

Testing maximal electron and muon neutrino oscillations with sub-GeV SuperKamiokande atmospheric neutrino data

Motivated by the Exact Parity Model and other theories, the hypothesis that each of the known neutrinos oscillates maximally with a sterile partner has been put forward as an explanation of the atmospheric and solar neutrino anomalies. We provide detailed predictions for muon and electron flux ratios induced in the Kamiokande and SuperKamiokande detectors by sub-GeV atmospheric neutrinos. Several different, carefully chosen cuts on momentum and zenith angle are proposed, emphasizing the role of up-down flux asymmetries.Comment: LaTeX, 8 figures, 17 pages, version to appear in Phys. Rev. D Rapid Communication