A Review of the Physics of Comets and Its Experimental Investigation by an Instrumented Space Probe

Physics, chemistry, and cosmology review of comets and proposed space probe experiment

Aerocrane: A hybrid LTA aircraft for aerial crane applications

The Aerocrane, a hybrid aircraft, combines rotor lift with buoyant lift to offer VTOL load capability greatly in excess of helicopter technology while eliminating the airship problem of ballast transfer. In addition, the Aerocrane concept sharply reduces the mooring problem of airships and provides 360 deg vectorable thrust to supply a relatively large force component for control of gust loads. Designed for use in short range, ultra heavy lift missions, the Aerocrane operates in a performance envelope unsuitable for either helicopters or airships. Basic design considerations and potential problem areas of the concept are addressed

Resolving long-range spatial correlations in jammed colloidal systems using photon correlation imaging

We introduce a new dynamic light scattering method, termed photon correlation imaging, which enables us to resolve the dynamics of soft matter in space and time. We demonstrate photon correlation imaging by investigating the slow dynamics of a quasi two-dimensional coarsening foam made of highly packed, deformable bubbles and a rigid gel network formed by dilute, attractive colloidal particles. We find the dynamics of both systems to be determined by intermittent rearrangement events. For the foam, the rearrangements extend over a few bubbles, but a small dynamical correlation is observed up to macroscopic length scales. For the gel, dynamical correlations extend up to the system size. These results indicate that dynamical correlations can be extremely long-ranged in jammed systems and point to the key role of mechanical properties in determining their nature.Comment: Published version (Phys. Rev. Lett. 102, 085702 (2009)) The Dynamical Activity Mapsprovided as Supplementary Online Material are also available on http://w3.lcvn.univ-montp2.fr/~lucacip/dam/movies.ht

COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus cells.

The nucleus pulposus (NP) of intervertebral discs experiences dynamic changes in tissue osmolarity because of diurnal loading of the spine. TonEBP/NFAT5 is a transcription factor that is critical in osmoregulation as well as survival of NP cells in the hyperosmotic milieu. The goal of this study was to investigate whether cyclooxygenase-2 (COX-2) expression is osmoresponsive and dependent on TonEBP, and whether it serves an osmoprotective role. NP cells up-regulated COX-2 expression in hyperosmotic media. The induction of COX-2 depended on elevation of intracellular calcium levels and p38 MAPK pathway, but independent of calcineurin signaling as well as MEK/ERK and JNK pathways. Under hyperosmotic conditions, both COX-2 mRNA stability and its proximal promoter activity were increased. The proximal COX-2 promoter (-1840/+123 bp) contained predicted binding sites for TonEBP, AP-1, NF-κB, and C/EBP-β. While COX-2 promoter activity was positively regulated by both AP-1 and NF-κB, AP-1 had no effect and NF-κB negatively regulated COX-2 protein levels under hyperosmotic conditions. On the other hand, TonEBP was necessary for both COX-2 promoter activity and protein up-regulation in response to hyperosmotic stimuli

Pairwise alignment incorporating dipeptide covariation

Motivation: Standard algorithms for pairwise protein sequence alignment make the simplifying assumption that amino acid substitutions at neighboring sites are uncorrelated. This assumption allows implementation of fast algorithms for pairwise sequence alignment, but it ignores information that could conceivably increase the power of remote homolog detection. We examine the validity of this assumption by constructing extended substitution matrixes that encapsulate the observed correlations between neighboring sites, by developing an efficient and rigorous algorithm for pairwise protein sequence alignment that incorporates these local substitution correlations, and by assessing the ability of this algorithm to detect remote homologies. Results: Our analysis indicates that local correlations between substitutions are not strong on the average. Furthermore, incorporating local substitution correlations into pairwise alignment did not lead to a statistically significant improvement in remote homology detection. Therefore, the standard assumption that individual residues within protein sequences evolve independently of neighboring positions appears to be an efficient and appropriate approximation

Deterministic stabilization of eight-way 2D diffractive beam combining using pattern recognition.

We demonstrate a new method for controlling diffractive, high-power beam combination, sensing phase errors by analyzing the intensity pattern of uncombined side beams at the output. A square array of eight beams is combined with <0.3% stability and 84.6% efficiency. As the channel count is increased, so does the usable information, enabling scaling to large channel counts without significant slowing of control loop response time, an advantage over single-input algorithms

The Hydrogen Epoch of Reionization Array Dish I: Beam Pattern Measurements and Science Implications

The Hydrogen Epoch of Reionization Array (HERA) is a radio interferometer aiming to detect the power spectrum of 21 cm fluctuations from neutral hydrogen from the Epoch of Reionization (EOR). Drawing on lessons from the Murchison Widefield Array (MWA) and the Precision Array for Probing the Epoch of Reionization (PAPER), HERA is a hexagonal array of large (14 m diameter) dishes with suspended dipole feeds. Not only does the dish determine overall sensitivity, it affects the observed frequency structure of foregrounds in the interferometer. This is the first of a series of four papers characterizing the frequency and angular response of the dish with simulations and measurements. We focus in this paper on the angular response (i.e., power pattern), which sets the relative weighting between sky regions of high and low delay, and thus, apparent source frequency structure. We measure the angular response at 137 MHz using the ORBCOMM beam mapping system of Neben et al. We measure a collecting area of 93 m^2 in the optimal dish/feed configuration, implying HERA-320 should detect the EOR power spectrum at z~9 with a signal-to-noise ratio of 12.7 using a foreground avoidance approach with a single season of observations, and 74.3 using a foreground subtraction approach. Lastly we study the impact of these beam measurements on the distribution of foregrounds in Fourier space.Comment: 13 pages, 9 figures. Replaced to match accepted ApJ versio

Virginia Woolf\u27s Views on the Necessity of Education for Girls

This paper examines Virginia Woolf’s views regarding educational equality for women and girls. It traces her views through her non-fiction works A Room of One’s Own and Three Guineas and through the modern era with an analysis of activist Malala Yousafzai’s views on educational reform and educational equality for all children displayed in her memoir I Am Malala. The paper seeks to prove that Woolf believed a well-educated female populous could help dismantle the type of masculine, violent culture that was constantly at war, both throughout her life and throughout history, and contribute to lasting world peace and prosperity. Woolf believes that this end is possible through the influence of a well-educated woman over the men in her life, that their expanded consciousness and sense of good could be used to influence men to make more peaceful decisions. Malala Yousafzai’s memoir asserts that the world will thrive if all children have equal access to high quality education, which will be influential in their moral development and shape a worldview based on peace and total equality. A combined analysis of these texts and application of Woolf’s ideas to the modern condition reveals that her assertion very well may prove to be true